The Impact of Sprint Interval Training Frequency on Blood Glucose Control and Physical Function of Older Adults (2020)
Journal Article
Adamson, S., Kavaliauskas, M., Lorimer, R., & Babraj, J. (2020). The Impact of Sprint Interval Training Frequency on Blood Glucose Control and Physical Function of Older Adults. International Journal of Environmental Research and Public Health, 17(2), 454. https://doi.org/10.3390/ijerph17020454

Exercise is a powerful tool for improving health in older adults, but the minimum frequency required is not known. This study sought to determine the effect of training frequency of sprint interval training (SIT) on health and physical function in ol... Read More about The Impact of Sprint Interval Training Frequency on Blood Glucose Control and Physical Function of Older Adults.

In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography (2019)
Journal Article
Madi, K., Staines, K., Bay, B., Javaheri, B., Geng, H., Bodey, A., Cartmell, S., Pitsillides, A., & Lee, P. (2020). In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography. Nature Biomedical Engineering, 4(3), 343-354. https://doi.org/10.1038/s41551-019-0477-1

Imaging techniques for quantifying changes in the hierarchical structure of deforming joints are constrained by destructive sample treatments, sample-size restrictions and lengthy scan times. Here, we report the use of fast low-dose pink-beam synchro... Read More about In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography.

A Biomechanical Analysis of British Army Foot-Drill: Implications of Lower-Extremity Musculoskeletal Injury in Age-matched Civilian Men and Women (2019)
Thesis
Rawcliffe, A. J. A Biomechanical Analysis of British Army Foot-Drill: Implications of Lower-Extremity Musculoskeletal Injury in Age-matched Civilian Men and Women. (Thesis). Edinburgh Napier University. http://researchrepository.napier.ac.uk/Output/2090019

British Army foot-drill may be a risk factor for musculoskeletal (MSK) injury. However, limited empirical research exists quantifying lower-extremity risk factors of foot-drill in men and women. To better understand and provide greater insight into t... Read More about A Biomechanical Analysis of British Army Foot-Drill: Implications of Lower-Extremity Musculoskeletal Injury in Age-matched Civilian Men and Women.

Blood flow restriction exercise attenuates the exercise-induced endothelial progenitor cells in healthy, young men. (2019)
Journal Article
Montgomery, R., Paterson, A., Williamson, C., Florida-James, G., & Ross, M. D. (2019). Blood flow restriction exercise attenuates the exercise-induced endothelial progenitor cells in healthy, young men. Frontiers in Physiology, https://doi.org/10.3389/fphys.2019.00447

Endothelial progenitor cells (EPCs) are a vasculogenic subset of progenitors, which play a key role in maintenance of endothelial integrity. These cells are exercise-responsive, and thus exercise may play a key role in vascular repair and maintenance... Read More about Blood flow restriction exercise attenuates the exercise-induced endothelial progenitor cells in healthy, young men..

Circulating angiogenic cell response to sprint interval and continuous exercise. (2019)
Journal Article
O'Carroll, L., Wardrop, B., Murphy, R. P., Ross, M. D., & Harrison, M. (2019). Circulating angiogenic cell response to sprint interval and continuous exercise. European Journal of Applied Physiology, 119(3), 743-752. https://doi.org/10.1007/s00421-018-04065-7

Although commonly understood as immune cells, certain T lymphocyte and monocyte subsets have angiogenic potential, contributing to blood vessel growth and repair. These cells are highly exercise responsive and may contribute to the cardiovascular ben... Read More about Circulating angiogenic cell response to sprint interval and continuous exercise..

Low Volume, Home-Based Weighted Step Exercise Training Can Improve Lower Limb Muscle Power and Functional Ability in Community-Dwelling Older Women (2019)
Journal Article
Mair, J. L., De Vito, G., & Boreham, C. A. (2019). Low Volume, Home-Based Weighted Step Exercise Training Can Improve Lower Limb Muscle Power and Functional Ability in Community-Dwelling Older Women. Journal of Clinical Medicine, 8(1), 41. https://doi.org/10.3390/jcm8010041

Stepping exercise can be used as a scalable form of high intensity exercise to enhance important aspects of physical fitness in older populations. The addition of supplementary weights increases the resistive element of stepping, with the potential f... Read More about Low Volume, Home-Based Weighted Step Exercise Training Can Improve Lower Limb Muscle Power and Functional Ability in Community-Dwelling Older Women.

Determination of ankle and metatarsophalangeal stiffness during walking and jogging (2018)
Journal Article
Mager, F., Richards, J., Hennies, M., Dötzel, E., Chohan, A., Mbuli, A., & Capanni, F. (2018). Determination of ankle and metatarsophalangeal stiffness during walking and jogging. Journal of Applied Biomechanics, 34(6), 448-453. https://doi.org/10.1123/jab.2017-0265

Forefoot stiffness has been shown to influence joint biomechanics. However, little or no data exist on metatarsophalangeal stiffness. Twenty-four healthy rearfoot strike runners were recruited from a staff and student population at the University of... Read More about Determination of ankle and metatarsophalangeal stiffness during walking and jogging.

Providing pupils autonomous use of sit-stand desks; behaviour changes and teacher and pupil opinion following an 8 week intervention (2018)
Presentation / Conference Contribution
Fowler, S., Pitkethly, A., Booth, J., Sproule, J., & Hutson, D. (2018, October). Providing pupils autonomous use of sit-stand desks; behaviour changes and teacher and pupil opinion following an 8 week intervention. Presented at 7th International Society for Physical Activity and Health Congress, London, UK

Parallel oral session : Wednesday 17th October

FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression (2017)
Journal Article
Ikpegbu, E., Basta, L., Clements, D. N., Fleming, R., Vincent, T. L., Buttle, D. J., Pitsillides, A. A., Staines, K. A., & Farquharson, C. (2018). FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression. Journal of Cellular Physiology, 233(7), 5334-5347. https://doi.org/10.1002/jcp.26345

E11/podoplanin is critical in the early stages of osteoblast-to-osteocyte transitions (osteocytogenesis) however the upstream events which regulate E11 expression are unknown. The aim of this study was to examine the effects of FGF-2 on E11-mediated... Read More about FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression.

The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following (2017)
Presentation / Conference Contribution
Baudel, M., Rae, M., Fraser, J., & Poole, A. (2017, April). The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following. Presented at BNA 2017

Stroke is one of the major causes of death and disability worldwide. The harm caused by the interruption of blood flow to the brain unfolds in the subsequent hours and days, so it is critical to identify new therapeutic targets that could reduce neur... Read More about The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following.

Vascular Ageing and Exercise: Focus on Cellular Reparative Processes (2016)
Journal Article
Ross, M. D., Malone, E., & Florida-James, G. (2016). Vascular Ageing and Exercise: Focus on Cellular Reparative Processes. Oxidative Medicine and Cellular Longevity, 2016, 1-15. https://doi.org/10.1155/2016/3583956

Ageing is associated with an increased risk of developing noncommunicable diseases (NCDs), such as diabetes and cardiovascular disease (CVD). The increased risk can be attributable to increased prolonged exposure to oxidative stress. Often, CVD is pr... Read More about Vascular Ageing and Exercise: Focus on Cellular Reparative Processes.

Chloride co-transporters as possible therapeutic targets for stroke (2016)
Journal Article
Martín-Aragón Baudel, M. A. S., Martín-Aragón Baudel, M. A. S., Poole, A. V., & Darlison, M. G. (2017). Chloride co-transporters as possible therapeutic targets for stroke. Journal of Neurochemistry, 140(2), 195-209. https://doi.org/10.1111/jnc.13901

Stroke is one of the major causes of death and disability worldwide. The major type of stroke is an ischaemic one, which is caused by a blockage that interrupts blood flow to the brain. There are currently very few pharmacological strategies to red... Read More about Chloride co-transporters as possible therapeutic targets for stroke.

Models of ex vivo explant cultures: applications in bone research (2016)
Journal Article
Marino, S., Staines, K. A., Brown, G., Howard-Jones, R. A., & Adamczyk, M. (2016). Models of ex vivo explant cultures: applications in bone research. BoneKEy Reports, 5, 818. https://doi.org/10.1038/bonekey.2016.49

Ex vivo explant culture models are powerful tools in bone research. They allow investigation of bone and cartilage responses to specific stimuli in a controlled manner that closely mimics the in vivo processes. Because of limitations in
obtaining he... Read More about Models of ex vivo explant cultures: applications in bone research.

Antiviral host defence peptides. (2016)
Book Chapter
Sousa, F. H., Casanova, V., Stevens, C., & Barlow, P. G. (2016). Antiviral host defence peptides. In R. M. Epand (Ed.), Host Defense Peptides and Their Potential as Therapeutic Agents (57-94). Springer. https://doi.org/10.1007/978-3-319-32949-9_3

The on going global mortality and morbidity associated with viral pathogens highlights the need for the continued development of effective, novel antiviral molecules. The antiviral activity of cationic host defence peptides is of significant interest... Read More about Antiviral host defence peptides..

Physical activity and cancer: movement matters. (2015)
Presentation / Conference Contribution
Campbell, A. (2015, December). Physical activity and cancer: movement matters. Presented at Living with and beyond cancer: a masterclass for primary care

Exercise and cancer survivorship: from evidence to practice. (2015)
Presentation / Conference Contribution
Campbell, A., & Courneya, K. (2015, December). Exercise and cancer survivorship: from evidence to practice. Paper presented at BASES conference 2015

The influence of age and cardiorespiratory fitness on circulating angiogenic T cells and CXCR4 expression. (2015)
Presentation / Conference Contribution
Ross, M. D., Malone, E. M., Simpson, R. J., & Florida-James, G. (2015, May). The influence of age and cardiorespiratory fitness on circulating angiogenic T cells and CXCR4 expression. Presented at Annual Congress of the American College of Sports Medicine (ACSM)

Aging is associated with endothelial dysfunction, reduced angiogenic capabilities, and an increase in arterial stiffness. Additionally, regular exercise is known to offset the age-related decline in blood vessel number and function. Circulating angio... Read More about The influence of age and cardiorespiratory fitness on circulating angiogenic T cells and CXCR4 expression..

Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1: SOCS2 REGULATION OF GH INDUCED GROWTH (2015)
Journal Article
Dobie, R., Ahmed, S. F., Staines, K. A., Pass, C., Jasim, S., MacRae, V. E., & Farquharson, C. (2015). Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1: SOCS2 REGULATION OF GH INDUCED GROWTH. Journal of Cellular Physiology, 230(11), 2796-2806. https://doi.org/10.1002/jcp.25006

Growth hormone (GH) signaling is essential for postnatal linear bone growth, but the relative importance of GHs actions on the liver and/or growth plate cartilage remains unclear. The importance of liver derived insulin like-growth factor-1 (IGF-1) f... Read More about Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1: SOCS2 REGULATION OF GH INDUCED GROWTH.

GABAA receptor chloride channels are involved in the neuroprotective role of GABA following oxygen and glucose deprivation in the rat cerebral cortex but not in the hippocampus (2013)
Journal Article
Darlison, M. G., Dos-Anjos, S., Llorente, I. L., Llorente, I. L., Perez-Rodriguez, D., Martínez-Villayandre, B., Dos Anjos, S., Darlison, M. G., Poole, A. V., & Fernández-López, A. (2013). GABAA receptor chloride channels are involved in the neuroprotective role of GABA following oxygen and glucose deprivation in the rat cerebral cortex but not in the hippocampus. Brain Research, 1533, 141-151. https://doi.org/10.1016/j.brainres.2013.08.024

Assays on "ex vivo" sections of rat hippocampus and rat cerebral cortex, subjected to oxygen and glucose deprivation (OGD) and a three-hour reperfusion-like (RL) recovery, were performed in the presence of either GABA or the GABA(A) receptor binding... Read More about GABAA receptor chloride channels are involved in the neuroprotective role of GABA following oxygen and glucose deprivation in the rat cerebral cortex but not in the hippocampus.

Excess Androgens in Utero Alters Fetal Testis Development (2013)
Journal Article
Connolly, F., Rae, M. T., Bittner, L., Hogg, K., McNeilly, A. S., & Duncan, W. C. (2013). Excess Androgens in Utero Alters Fetal Testis Development. Endocrinology, 154(5), 1921-1933. https://doi.org/10.1210/en.2012-2153

Prenatal androgenization induces a polycystic ovary syndrome-like phenotype in adult female offspring, which is associated with alterations that can be detected in the fetal ovary, suggesting gestational origins of this condition. We therefore invest... Read More about Excess Androgens in Utero Alters Fetal Testis Development.