Ekele Ikpegbu
FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression
Ikpegbu, Ekele; Basta, Lena; Clements, Dylan N.; Fleming, Robert; Vincent, Tonia L.; Buttle, David J.; Pitsillides, Andrew A.; Staines, Katherine A.; Farquharson, Colin
Authors
Lena Basta
Dylan N. Clements
Robert Fleming
Tonia L. Vincent
David J. Buttle
Andrew A. Pitsillides
Katherine A. Staines
Colin Farquharson
Abstract
E11/podoplanin is critical in the early stages of osteoblast-to-osteocyte transitions (osteocytogenesis) however the upstream events which regulate E11 expression are unknown. The aim of this study was to examine the effects of FGF-2 on E11-mediated osteocytogenesis and to reveal the nature of the underlying signaling pathways regulating this process. Exposure of MC3T3 osteoblast-like cells and murine primary osteoblasts to FGF-2 (10ng/ml) increased E11 mRNA and protein expression (P
Citation
Ikpegbu, E., Basta, L., Clements, D. N., Fleming, R., Vincent, T. L., Buttle, D. J., …Farquharson, C. (2018). FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression. Journal of Cellular Physiology, 233(7), 5334-5347. https://doi.org/10.1002/jcp.26345
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 29, 2017 |
Online Publication Date | Dec 7, 2017 |
Publication Date | Jan 23, 2018 |
Deposit Date | Nov 30, 2017 |
Publicly Available Date | Feb 13, 2018 |
Journal | Journal of Cellular Physiology |
Print ISSN | 0021-9541 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 233 |
Issue | 7 |
Pages | 5334-5347 |
DOI | https://doi.org/10.1002/jcp.26345 |
Keywords | Osteocytes, osteoblasts, E11/podoplanin, FGF-2, osteocytogenesis. |
Public URL | http://researchrepository.napier.ac.uk/Output/1015193 |
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FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression
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http://creativecommons.org/licenses/by/4.0/
Copyright Statement
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
© 2017 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc.
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