Ryan Montgomery
Blood flow restriction exercise attenuates the exercise-induced endothelial progenitor cells in healthy, young men.
Montgomery, Ryan; Paterson, Allan; Williamson, Christopher; Florida-James, Geraint; Ross, Mark D.
Authors
Allan Paterson
Christopher Williamson
Prof G Florida-James G.Florida-James@napier.ac.uk
Professor
Mark D. Ross
Abstract
Endothelial progenitor cells (EPCs) are a vasculogenic subset of progenitors, which play a key role in maintenance of endothelial integrity. These cells are exercise-responsive, and thus exercise may play a key role in vascular repair and maintenance via mobilization of such cells. Blood flow restriction exercise, due to the augmentation of local tissue hypoxia, may promote exercise-induced EPC mobilization. Nine, healthy, young (18-30yrs) males participated in the study. Participants undertook 2 trials of single leg knee extensor (KE) exercise, at 60% of thigh occlusion pressure (4 sets at 30% maximal torque) (BFR) or non- blood flow restricted (non-BFR), in a fasted state. Blood was taken prior, immediately after, and 30 minutes after exercise. Blood was used for the quantification of haematopoietic progenitor cells (HPCs: CD34+CD45dim), EPCs (CD34+VEGFR2+/CD34+CD45dimVEGFR2+) by flow cytometry. Our results show that unilateral KE exercise did not affect circulating HPC levels (p = 0.856), but did result in increases in both CD34+VEGFR2+ and CD34+CD45dimVEGFR2+ EPCs, but only in the non-BFR trial (CD34+VEGFR2+: 269 ± 42 cells·mL-1 to 573 ± 90 cells·mL-1, pre- to immediately post-exercise, p = 0.008; CD34+CD45dimVEGFR2+: 129 ± 21 cells·mL-1 to 313 ± 103 cells·mL-1, pre- to 30 min post-exercise, p = 0.010). In conclusion, low intensity BFR exercise did not result in significant circulating changes in EPCs in the post-exercise recovery period and may impair exercise-induced EPC mobilization compared to non-BFR exercise.
Citation
Montgomery, R., Paterson, A., Williamson, C., Florida-James, G., & Ross, M. D. (2019). Blood flow restriction exercise attenuates the exercise-induced endothelial progenitor cells in healthy, young men. Frontiers in Physiology, https://doi.org/10.3389/fphys.2019.00447
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 1, 2019 |
Online Publication Date | Apr 17, 2019 |
Publication Date | Apr 17, 2019 |
Deposit Date | Apr 2, 2019 |
Publicly Available Date | Apr 2, 2019 |
Journal | Frontiers in Physiology |
Electronic ISSN | 1664-042X |
Publisher | Frontiers Media |
Peer Reviewed | Peer Reviewed |
DOI | https://doi.org/10.3389/fphys.2019.00447 |
Keywords | Endothelial progenitor, Blood flow restricted exercise, Exercise, Endothelium, Angiogenesis , |
Public URL | http://researchrepository.napier.ac.uk/Output/1701305 |
Files
Blood Flow Restriction Exercise Attenuates the Exercise-Induced Endothelial Progenitor Cells in Healthy, Young Men
(214 Kb)
PDF
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
Blood Flow Restriction Exercise Attenuates the Exercise-Induced Endothelial Progenitor Cell Response in Healthy, Young Men
(821 Kb)
PDF
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
You might also like
Vascular Manifestations of COVID-19 -Thromboembolism and Microvascular Dysfunction
(2020)
Journal Article
Downloadable Citations
About Edinburgh Napier Research Repository
Administrator e-mail: repository@napier.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search