Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1: SOCS2 REGULATION OF GH INDUCED GROWTH

Dobie, Ross; Ahmed, Syed F.; Staines, Katherine A.; Pass, Chloe; Jasim, Seema; MacRae, Vicky E.; Farquharson, Colin

Abstract

Growth hormone (GH) signaling is essential for postnatal linear bone growth, but the relative importance of GHs actions on the liver and/or growth plate cartilage remains unclear. The importance of liver derived insulin like-growth factor-1 (IGF-1) for endochondral growth has recently been challenged. Here, we investigate linear growth in Suppressor of Cytokine Signaling-2 (SOCS2) knockout mice, which have enhanced growth despite normal systemic GH/IGF-1 levels. Wild-type embryonic ex vivo metatarsals failed to exhibit increased linear growth in response to GH, but displayed increased Socs2 transcript levels (P 

• Journal Article Type: Article
• Acceptance Date: Mar 30, 2015
• Online Publication Date: Apr 1, 2015
• Publication Date: 2015-11
• Deposit Date: Jan 20, 2017
• Publicly Available Date: Jan 20, 2017
• Journal: Journal of Cellular Physiology
• Print ISSN: 0021-9541
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 230
• Issue: 11
• Pages: 2796-2806
• DOI: https://doi.org/10.1002/jcp.25006
• Keywords: Clinical Biochemistry; Cell Biology; Physiology
• Public URL: http://researchrepository.napier.ac.uk/Output/466154
• Contract Date: Jan 20, 2017