Circulating angiogenic cell response to sprint interval and continuous exercise.

O'Carroll, Louis; Wardrop, Bruce; Murphy, Ronan P.; Ross, Mark D.; Harrison, Michael

Abstract

Although commonly understood as immune cells, certain T lymphocyte and monocyte subsets have angiogenic potential, contributing to blood vessel growth and repair. These cells are highly exercise responsive and may contribute to the cardiovascular benefits seen with exercise.
Purpose: To compare the effects of a single bout of continuous (CONTEX) and sprint interval exercise (SPRINT) on circulating angiogenic cells (CAC) in healthy recreationally active adults.
Methods: Twelve participants (aged 29 ±2y, BMI 25.5±0.9 kg.m-28 2, 𝑉̇O2peak 44.3±1.8 ml.kg-1.min-1; mean±SEM) participated in the study. Participants completed a 45 min bout of CONTEX at 70% peak oxygen uptake and 6x20 sec sprints on a 30 cycle ergometer, in a counterbalanced design. Blood was sampled pre-, post-, 2h and 24h post-31 exercise for quantification of CAC subsets by whole blood flow cytometric analysis. Angiogenic T lymphocytes (TANG) and angiogenic Tie2-expressing monocytes (TEM) were 33 identified by the expression of CD31 and Tie2 respectively.
Results: Circulating (cells.μL-1) 34 CD3+CD31+TANG increased immediately post-exercise in both trials (p

Citation

O'Carroll, L., Wardrop, B., Murphy, R. P., Ross, M. D., & Harrison, M. (2019). Circulating angiogenic cell response to sprint interval and continuous exercise. European Journal of Applied Physiology, 119(3), 743-752. https://doi.org/10.1007/s00421-018-04065-7

• Journal Article Type: Article
• Acceptance Date: Dec 23, 2018
• Online Publication Date: Jan 23, 2019
• Publication Date: 2019-03
• Deposit Date: Jan 4, 2019
• Publicly Available Date: Jan 23, 2019
• Print ISSN: 1439-6319
• Electronic ISSN: 1439-6327
• Publisher: Springer
• Peer Reviewed: Peer Reviewed
• Volume: 119
• Issue: 3
• Pages: 743-752
• DOI: https://doi.org/10.1007/s00421-018-04065-7
• Keywords: Angiogenic T cells; Tie2 expressing monocytes, endothelial progenitor cells; high 45 intensity exercise
• Public URL: http://researchrepository.napier.ac.uk/Output/1481714
• Contract Date: Jan 4, 2019