Skip to main content

Research Repository

Advanced Search

Circulating angiogenic cell response to sprint interval and continuous exercise.

O'Carroll, Louis; Wardrop, Bruce; Murphy, Ronan P.; Ross, Mark D.; Harrison, Michael

Authors

Louis O'Carroll

Bruce Wardrop

Ronan P. Murphy

Mark D. Ross

Michael Harrison



Abstract

Although commonly understood as immune cells, certain T lymphocyte and monocyte subsets have angiogenic potential, contributing to blood vessel growth and repair. These cells are highly exercise responsive and may contribute to the cardiovascular benefits seen with exercise.
Purpose: To compare the effects of a single bout of continuous (CONTEX) and sprint interval exercise (SPRINT) on circulating angiogenic cells (CAC) in healthy recreationally active adults.
Methods: Twelve participants (aged 29 ±2y, BMI 25.5±0.9 kg.m-28 2, 𝑉̇O2peak 44.3±1.8 ml.kg-1.min-1; mean±SEM) participated in the study. Participants completed a 45 min bout of CONTEX at 70% peak oxygen uptake and 6x20 sec sprints on a 30 cycle ergometer, in a counterbalanced design. Blood was sampled pre-, post-, 2h and 24h post-31 exercise for quantification of CAC subsets by whole blood flow cytometric analysis. Angiogenic T lymphocytes (TANG) and angiogenic Tie2-expressing monocytes (TEM) were 33 identified by the expression of CD31 and Tie2 respectively.
Results: Circulating (cells.μL-1) 34 CD3+CD31+TANG increased immediately post-exercise in both trials (p

Citation

O'Carroll, L., Wardrop, B., Murphy, R. P., Ross, M. D., & Harrison, M. (2019). Circulating angiogenic cell response to sprint interval and continuous exercise. European Journal of Applied Physiology, 119(3), 743-752. https://doi.org/10.1007/s00421-018-04065-7

Journal Article Type Article
Acceptance Date Dec 23, 2018
Online Publication Date Jan 23, 2019
Publication Date 2019-03
Deposit Date Jan 4, 2019
Publicly Available Date Mar 29, 2024
Print ISSN 1439-6319
Electronic ISSN 1439-6327
Publisher Springer
Peer Reviewed Peer Reviewed
Volume 119
Issue 3
Pages 743-752
DOI https://doi.org/10.1007/s00421-018-04065-7
Keywords Angiogenic T cells; Tie2 expressing monocytes, endothelial progenitor cells; high 45 intensity exercise;
Public URL http://researchrepository.napier.ac.uk/Output/1481714

Files




You might also like



Downloadable Citations