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Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration (2004)
Journal Article
Barlow, P., Donaldson, K., MacCallum, J., Clouter, A., & Stone, V. (2005). Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration. Toxicology Letters, 155(3), 397-401. https://doi.org/10.1016/j.toxlet.2004.11.006

Objective:
To assess whether fine and ultrafine particles (nanoparticles) have the capacity to activate factors in serum that would induce macrophage migration. This is a model previously reported to investigate complement activation by other respir... Read More about Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration.

Interferon-γ polymorphisms correlate with duration of survival in pancreatic cancer (2004)
Journal Article
Halma, M., Wheelhouse, N., Barber, M., Powell, J., Fearon, K., & Ross, J. (2004). Interferon-γ polymorphisms correlate with duration of survival in pancreatic cancer. Human Immunology, 65(11), 1405-1408. https://doi.org/10.1016/j.humimm.2004.08.184

Despite progress in diagnosis and staging, pancreatic cancer still has a poor prognosis and it remains difficult to predict duration of survival in advanced pancreatic cancer. Nutritional decline, or cachexia, is a contributory factor to decreased su... Read More about Interferon-γ polymorphisms correlate with duration of survival in pancreatic cancer.

Older people with cancer: perceptions and feelings about information, decision-making and treatment—a pilot study (2004)
Journal Article
Chouliara, Z., Miller, M., Stott, D., Molassiotis, A., Twelves, C., & Kearney, N. (2004). Older people with cancer: perceptions and feelings about information, decision-making and treatment—a pilot study. European Journal of Oncology Nursing, 8(3), 257-261. https://doi.org/10.1016/j.ejon.2003.12.010

Several studies have identified inadequacies in the care and treatment received by older patients with cancer, as opposed to their younger counterparts. These include over or under diagnosis, ineffective symptom management and lower survival rates in... Read More about Older people with cancer: perceptions and feelings about information, decision-making and treatment—a pilot study.

Apoptosis induced by Paclitaxel, tobacco smoke condensate and hydrogen peroxide in lung epithelial cells (A549) (2004)
Presentation / Conference Contribution
Ramage, L., Jones, A., & Whelan, C. Apoptosis induced by Paclitaxel, tobacco smoke condensate and hydrogen peroxide in lung epithelial cells (A549)

Cigarette smoke is known to be a complex mixture of >4000 constituents dispersed between the volatile and non-volatile phase, and inhaled exposure causes lung inflammation and cell injury. Here we investigate the effects of some of components of ciga... Read More about Apoptosis induced by Paclitaxel, tobacco smoke condensate and hydrogen peroxide in lung epithelial cells (A549).

A phenomenological study of the lived experiences of people with lymphoedema. (2004)
Journal Article
Williams, A., Moffatt, C., & Franks, P. (2004). A phenomenological study of the lived experiences of people with lymphoedema. International Journal of Palliative Nursing, 10, 279-286

Lymphoedema occurs in all age groups and is caused by lymphatic insufficiency. It is associated with a wide range of cancer- and non-cancer-related conditions. Researchers have explored the impact of lymphoedema on quality of life but most studies ha... Read More about A phenomenological study of the lived experiences of people with lymphoedema..

Childhood H. pylori: disappearing disease or chronic infection? (2004)
Journal Article
Shepherd, A., Malcolm, C., Mackay, W. G., & Weaver, L. T. (2004). Childhood H. pylori: disappearing disease or chronic infection?. British Journal of Community Nursing, 9(5), 201-205. https://doi.org/10.12968/bjcn.2004.9.5.12888

Helicobacter pylori is one of the commonest chronic bacterial infections worldwide. It is acquired during childhood and its persistence has implications for health in later life. In adults, it is the principle cause of duodenal ulcer disease and ther... Read More about Childhood H. pylori: disappearing disease or chronic infection?.

Inhibition of neutrophil recruitment by ES of Nippostrongylus brasiliensis (2004)
Journal Article
Keir, P. A., Brown, D. M., Clouter-Baker, A., Harcus, Y. M., & Proudfoot, L. (2004). Inhibition of neutrophil recruitment by ES of Nippostrongylus brasiliensis. Parasite Immunology, 26(3), 137-139. https://doi.org/10.1111/j.0141-9838.2004.00692.x

It has been reported that excretory–secretory (ES) material from the parasitic nematode Nippostrongylus brasiliensis has potential modulatory effects on the host's immune system. We observed that intratracheal instillation of ES from the L3 stage of... Read More about Inhibition of neutrophil recruitment by ES of Nippostrongylus brasiliensis.

Aphasia rehabilitation and the strange neglect of speed (2004)
Journal Article
Crerar, A. (2004). Aphasia rehabilitation and the strange neglect of speed. Neuropsychological Rehabilitation, 14(1-2), 173-206. https://doi.org/10.1080/09602010343000174

Timing data is infrequently reported in aphasiological literature and time taken is only a minor factor, where it is considered at all, in existing aphasia assessments. This is not surprising because reaction times are difficult to obtain manually, b... Read More about Aphasia rehabilitation and the strange neglect of speed.

Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles (2004)
Journal Article
Brown, D. M., Donaldson, K., Borm, P. J., Schins, R. P., Dehnhardt, M., Gilmour, P., Jimenez, L. A., & Stone, V. (2004). Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles. American Journal of Physiology - Lung Cellular and Molecular Physiology, 286(2), L344-L353. https://doi.org/10.1152/ajplung.00139.2003

Ultrafine (Uf) particles are a component of particulate air pollution suggested to be responsible for the health effects associated with elevations of this pollutant. We have previously suggested that Uf particles, through the induction of oxidative... Read More about Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles.

Expression of C-Reactive Protein and Heat-Shock Protein-70 in the Lung Epithelial Cell Line A549, in Response to PM10 Exposure (2004)
Journal Article
Ramage, L., & Guy, K. (2004). Expression of C-Reactive Protein and Heat-Shock Protein-70 in the Lung Epithelial Cell Line A549, in Response to PM10 Exposure. Inhalation Toxicology, 16(6-7), 447-452. https://doi.org/10.1080/08958370490439614

Increased levels of C-reactive protein (CRP) and heat-shock protein-70 (Hsp70) in plasma are known to be associated with an increased risk of cardiovascular disease. In this study we have investigated the effects of environmental air pollution partic... Read More about Expression of C-Reactive Protein and Heat-Shock Protein-70 in the Lung Epithelial Cell Line A549, in Response to PM10 Exposure.

Referrals of women with a family history of breast cancer from primary care to cancer genetics services in South East Scotland (2003)
Journal Article
Campbell, H., Holloway, S., Cetnarskyj, R., Anderson, E., Rush, R., Fry, A., Gorman, D., Steel, M., & Porteous, M. (2003). Referrals of women with a family history of breast cancer from primary care to cancer genetics services in South East Scotland. British Journal of Cancer, 89(9), 1650-1656. https://doi.org/10.1038/sj.bjc.6601348

As part of a cluster randomised trial to assess an alternative model of cancer genetics services, we gathered data on all referrals from general practitioners (GPs) to cancer genetics services in South East Scotland over a 4-year period. The referral... Read More about Referrals of women with a family history of breast cancer from primary care to cancer genetics services in South East Scotland.

Effects of prenatal undernutrition on emotional reactivity and cognitive flexibility in adult sheep (2003)
Journal Article
Erhard, H. W., Boissy, A., Rae, M. T., & Rhind, S. M. (2004). Effects of prenatal undernutrition on emotional reactivity and cognitive flexibility in adult sheep. Behavioural Brain Research, 151(1-2), 25-35. https://doi.org/10.1016/j.bbr.2003.08.003

The experiment reported was designed to test two hypotheses: that prenatal undernutrition (a) increases emotional reactivity and (b) impairs cognitive flexibility in sheep. The mothers of one group were fed live weight maintenance requirements throug... Read More about Effects of prenatal undernutrition on emotional reactivity and cognitive flexibility in adult sheep.

Lymphoedema: an underestimated health problem. (2003)
Journal Article
Mortimer, P., Franks, P., Doherty, D., Williams, A., Jeffs, E., Bosanquet, N., Moffatt, C., & Badger, C. (2003). Lymphoedema: an underestimated health problem. QJM: An International Journal of Medicine, 96(10), 731-873. https://doi.org/10.1093/qjmed/hcg126

Background: Lymphoedema/chronic oedema is an important cause of morbidity in the population, but little is known of its epidemiology and impact on patients or health services.

Aim: To determine the magnitude of the problem of chronic oedema in the... Read More about Lymphoedema: an underestimated health problem..

The influence of particle composition and size on in vitro and in vivo biological models. (2003)
Report
Lightbody, J., Hutchison, G. R., Donaldson, K., & Stone, V. (2003). The influence of particle composition and size on in vitro and in vivo biological models

Particulate air pollution has been consistently linked with an increase in morbidity and mortality due to respiratory complications and cardiovascular disease. The aim of this study was to investigate which components of PM10 are important in driving... Read More about The influence of particle composition and size on in vitro and in vivo biological models..

A randomized controlled crossover study of manual lymphatic drainage therapy in women with breast cancer-related lymphoedema (2002)
Journal Article
Williams, A. F., Vadgama, A., Franks, P. J., & Mortimer, P. S. (2002). A randomized controlled crossover study of manual lymphatic drainage therapy in women with breast cancer-related lymphoedema. European Journal of Cancer Care, 11(4), 254-261. https://doi.org/10.1046/j.1365-2354.2002.00312.x

This paper describes a randomized controlled crossover study examining the effects of manual lymphatic drainage (MLD) in 31 women with breast cancer-related lymphoedema. MLD is a type of massage used in combination with skin care, support/compression... Read More about A randomized controlled crossover study of manual lymphatic drainage therapy in women with breast cancer-related lymphoedema.

A preliminary evaluation of the differences in the glycosylation of alpha-1-acid glycoprotein between individual liver diseases. (2002)
Journal Article
Anderson, N. E., Pollacchi, A., Hayes, P., Therapondos, G., Newsome, P., Boyter, A., & Smith, K. (2002). A preliminary evaluation of the differences in the glycosylation of alpha-1-acid glycoprotein between individual liver diseases. Biomedical Chromatography, 16, 365-372. https://doi.org/10.1002/bmc.167

During the acute phase response (APR) to tissue injury or infection, the liver is responsible for the level of mediators such as cytokines required at the site of inflammation and providing the essential components for wound healing and tissue repair... Read More about A preliminary evaluation of the differences in the glycosylation of alpha-1-acid glycoprotein between individual liver diseases..

Inflammatory bowel disease: developing a short disease specific scale to measure health related quality of life (2002)
Journal Article
Smith, G., Watson, R., & Palmer, K. (2002). Inflammatory bowel disease: developing a short disease specific scale to measure health related quality of life. International Journal of Nursing Studies, 39(6), 583-590. https://doi.org/10.1016/s0020-7489%2801%2900042-6

Aim: To report on the preliminary development of a short scale, the Edinburgh inflammatory bowel disease questionnaire (EIBDQ) to measure disease specific aspects of inflammatory bowel disease (IBD) in terms of both physical impact and health related... Read More about Inflammatory bowel disease: developing a short disease specific scale to measure health related quality of life.

Alverine citrate fails to relieve the symptoms of irritable bowel syndrome: results of a double-blind, randomized, placebo-controlled trial (2002)
Journal Article
Mitchell, S. A., Mee, A. S., Smith, G. D., Palmer, K. R., & Chapman, R. W. (2002). Alverine citrate fails to relieve the symptoms of irritable bowel syndrome: results of a double-blind, randomized, placebo-controlled trial. Alimentary pharmacology & therapeutics, 16(6), 1187-1195. https://doi.org/10.1046/j.1365-2036.2002.01277.x

Background : Alverine citrate has been used in the treatment of irritable bowel syndrome for many years.

Aims : To compare the efficacy and safety of a new formulation of alverine citrate, a 120-mg capsule, with placebo given three times daily for... Read More about Alverine citrate fails to relieve the symptoms of irritable bowel syndrome: results of a double-blind, randomized, placebo-controlled trial.