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Cartilage development and degeneration: a Wnt Wnt situation - cartilage development and degeneration: a WNT WNT situation (2012)
Journal Article
Staines, K. A., MacRae, V. E., & Farquharson, C. (2012). Cartilage development and degeneration: a Wnt Wnt situation - cartilage development and degeneration: a WNT WNT situation. Cell Biochemistry and Function, 30(8), 633-642. https://doi.org/10.1002/cbf.2852

The Wnt signaling pathway plays a crucial role in the development and homeostasis of a variety of adult tissues and, as such, is emerging as an important therapeutic target for numerous diseases. Factors involved in the Wnt pathway are expressed thro... Read More about Cartilage development and degeneration: a Wnt Wnt situation - cartilage development and degeneration: a WNT WNT situation.

The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling (2012)
Journal Article
Staines, K. A., MacRae, V. E., & Farquharson, C. (2012). The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling. Journal of Endocrinology, 214(3), 241-255. https://doi.org/10.1530/joe-12-0143

The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein. These proteins share many structura... Read More about The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling.

Concordance in action: case study of medication management (2012)
Journal Article
Roy, D., & Snowden, A. (2012). Concordance in action: case study of medication management. Nurse Prescribing, 10(4), 195-200. https://doi.org/10.12968/npre.2012.10.4.195

This article discusses a case study describing discontinuation symptoms relating to the abrupt withdrawal of the antidepressant venlafaxine. The article explores alternative explanations for the symptoms presented, and highlights the importance of sy... Read More about Concordance in action: case study of medication management.

Effects of drop-out on efficacy estimates in five Cochrane reviews of popular antipsychotics for schizophrenia: Drop-out in Cochrane reviews of antipsychotics (2012)
Journal Article
Hutton, P., Morrison, A. P., Yung, A. R., Taylor, P. J., French, P., & Dunn, G. (2012). Effects of drop-out on efficacy estimates in five Cochrane reviews of popular antipsychotics for schizophrenia: Drop-out in Cochrane reviews of antipsychotics. Acta Psychiatrica Scandinavica, 126(1), 1-11. https://doi.org/10.1111/j.1600-0447.2012.01858.x

Objective:
Our aim was to find out how Cochrane reviews of five popular or frequently prescribed second-generation antipsychotics in the UK (olanzapine, risperidone, quetiapine, amisulpride and aripiprazole) approached the problem of high drop-out i... Read More about Effects of drop-out on efficacy estimates in five Cochrane reviews of popular antipsychotics for schizophrenia: Drop-out in Cochrane reviews of antipsychotics.

Measuring Concordance in Clinical Practice (2012)
Journal Article
Barron, D. T., & Snowden, A. (2012). Measuring Concordance in Clinical Practice. British Journal of Mental Health Nursing, 1(2), 88-94. https://doi.org/10.12968/bjmh.2012.1.2.88

This article describes the construction of a tool to measure concordance in clinical practice. The second of two parts, it details the strategic background underpinning concordance and expands the rationale as this relates to the construction of indi... Read More about Measuring Concordance in Clinical Practice.

Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep (2011)
Journal Article
Dolan, S., Gunn, M. D., Crossan, C., & Nolan, A. M. (2011). Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep. Behavioural Pharmacology, 22, 582-588. https://doi.org/10.1097/FBP.0b013e3283478802

This study set out to characterize the contribution of group III metabotropic glutamate receptor 7 activation to nociceptive behaviour and mechanical hypersensitivity in a novel formalin test in sheep. The mGlu receptor 7 allosteric agonist, N,N′-dib... Read More about Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep.

A preliminary exploration of predictors of outcome and cognitive mechanisms of change in cognitive behaviour therapy for psychosis in people not taking antipsychotic medication (2011)
Journal Article
Morrison, A. P., Turkington, D., Wardle, M., Spencer, H., Barratt, S., Dudley, R., Brabban, A., & Hutton, P. (2012). A preliminary exploration of predictors of outcome and cognitive mechanisms of change in cognitive behaviour therapy for psychosis in people not taking antipsychotic medication. Behaviour Research and Therapy, 50(2), 163-167. https://doi.org/10.1016/j.brat.2011.12.001

BACKGROUND:

Cognitive behaviour therapy (CBT) has been shown to be effective in an open trial for people with psychotic disorders who have not been taking antipsychotic medication. There is little known about predictors of outcome in CBT for psych... Read More about A preliminary exploration of predictors of outcome and cognitive mechanisms of change in cognitive behaviour therapy for psychosis in people not taking antipsychotic medication.

Prevalence of violence risk factors in people at ultra-high risk of developing psychosis: a service audit: Audit of violence risk in a UHR group (2011)
Journal Article
Hutton, P., Parker, S., Bowe, S., & Ford, S. (2012). Prevalence of violence risk factors in people at ultra-high risk of developing psychosis: a service audit: Audit of violence risk in a UHR group. Early Intervention in Psychiatry, 6(1), 91-96. https://doi.org/10.1111/j.1751-7893.2011.00307.x

Background: There is little data available on the prevalence of violence risk factors in people at ultra-high risk of developing psychosis.

Aim: The aim of this study was to provide an estimate of the cross-sectional prevalence of violence risk fa... Read More about Prevalence of violence risk factors in people at ultra-high risk of developing psychosis: a service audit: Audit of violence risk in a UHR group.

Prevalence of suicide risk factors in people at ultra-high risk of developing psychosis: a service audit: Suicide risk in UHR clients (2011)
Journal Article
Hutton, P., Bowe, S., Parker, S., & Ford, S. (2011). Prevalence of suicide risk factors in people at ultra-high risk of developing psychosis: a service audit: Suicide risk in UHR clients. Early Intervention in Psychiatry, 5(4), 375-380. https://doi.org/10.1111/j.1751-7893.2011.00302.x

Aim: The aim of this study was to provide an estimate of the cross-sectional prevalence of possible suicide risk factors in those attending a routine clinical service for people at UHR of developing psychosis.

Methods: For all patients in treatmen... Read More about Prevalence of suicide risk factors in people at ultra-high risk of developing psychosis: a service audit: Suicide risk in UHR clients.

Cognitive therapy for people with a schizophrenia spectrum diagnosis not taking antipsychotic medication: an exploratory trial (2011)
Journal Article
Morrison, A. P., Hutton, P., Wardle, M., Spencer, H., Barratt, S., Brabban, A., Callcott, P., Christodoulides, T., Dudley, R., French, P., Lumley, V., Tai, S. J., & Turkington, D. (2012). Cognitive therapy for people with a schizophrenia spectrum diagnosis not taking antipsychotic medication: an exploratory trial. Psychological Medicine, 42(05), 1049-1056. https://doi.org/10.1017/s0033291711001899

Although antipsychotic medication is the first line of treatment for schizophrenia, many service users choose to refuse or discontinue their pharmacological treatment. Cognitive therapy (CT) has been shown to be effective when delivered in combinatio... Read More about Cognitive therapy for people with a schizophrenia spectrum diagnosis not taking antipsychotic medication: an exploratory trial.

Acupuncture for gastrointestinal disorders (2011)
Journal Article
Smith, G. D. (2011). Acupuncture for gastrointestinal disorders. Gastrointestinal Nursing, 9(6), 15-16. https://doi.org/10.12968/gasn.2011.9.6.15

Summary
There is an increasing worldwide use of CAM in gastrointestinal diseases
„ Limited current evidence to support use of acupuncture in IBD and IBS
„ The best acupuncture evidence relates to management of nasuea and vomiting
„ It is importan... Read More about Acupuncture for gastrointestinal disorders.

Brief cognitive behavioural therapy for hallucinations: Can it help people who decide not to take antipsychotic medication? A case report (2011)
Journal Article
Hutton, P., Morrison, A. P., & Taylor, H. (2012). Brief cognitive behavioural therapy for hallucinations: Can it help people who decide not to take antipsychotic medication? A case report. Behavioural and Cognitive Psychotherapy, 40(1), 111-116

Background:
Cognitive behavioural therapy (CBT) can be helpful for many people who experience psychosis; however most research trials have been conducted with people also taking antipsychotic medication. There is little evidence to know whether CBT... Read More about Brief cognitive behavioural therapy for hallucinations: Can it help people who decide not to take antipsychotic medication? A case report.

Gut-directed hypnotherapy in irritable bowel syndrome (2011)
Journal Article
Smith, G. D. (2011). Gut-directed hypnotherapy in irritable bowel syndrome. Gastrointestinal Nursing, 9(4), 17-18. https://doi.org/10.12968/gasn.2011.9.4.17

Irritable bowel syndrome (IBS) is a chronic gastrointestinal (GI) condition characterized by abdominal pain, altered bowel habit (constipation and diarrhoea) and abdominal distension (Spiller et al, 2007). It is the most commonly seen condition in GI... Read More about Gut-directed hypnotherapy in irritable bowel syndrome.