Cartilage development and degeneration: a Wnt Wnt situation - cartilage development and degeneration: a WNT WNT situation

Staines, Katherine Ann; MacRae, Vicky Elizabeth; Farquharson, Colin

Abstract

The Wnt signaling pathway plays a crucial role in the development and homeostasis of a variety of adult tissues and, as such, is emerging as an important therapeutic target for numerous diseases. Factors involved in the Wnt pathway are expressed throughout limb development and chondrogenesis and have been shown to be critical in joint homeostasis and endochondral ossification. Therefore, in this review, we discuss Wnt regulation of chondrogenic differentiation, hypertrophy and cartilage function. Moreover, we detail the role of the Wnt signaling pathway in cartilage degeneration and its potential to act as a target for therapy in osteoarthritis.

Citation

Staines, K. A., MacRae, V. E., & Farquharson, C. (2012). Cartilage development and degeneration: a Wnt Wnt situation - cartilage development and degeneration: a WNT WNT situation. Cell Biochemistry and Function, 30(8), 633-642. https://doi.org/10.1002/cbf.2852

• Journal Article Type: Article
• Acceptance Date: May 20, 2012
• Online Publication Date: Jun 19, 2012
• Publication Date: Dec 5, 2012
• Deposit Date: Jan 20, 2017
• Journal: Cell Biochemistry and Function
• Print ISSN: 0263-6484
• Electronic ISSN: 1099-0844
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 30
• Issue: 8
• Pages: 633-642
• DOI: https://doi.org/10.1002/cbf.2852
• Keywords: Wnt signaling pathway, chondrogenesis, joint homeostasis, endochondral ossification, osteoarthritis,
• Public URL: http://researchrepository.napier.ac.uk/Output/466222