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Anti-inflammatory responses and oxidative stress in Nippostrongylus brasiliensis-induced pulmonary inflammation. (2002)
Journal Article
McNeil, K. S., Knox, D. P., & Proudfoot, L. (2002). Anti-inflammatory responses and oxidative stress in Nippostrongylus brasiliensis-induced pulmonary inflammation. Parasite Immunology, 24, 15-22. https://doi.org/10.1046/j.0141-9838.2001.00428.x

Migration of L3 larvae of Nippostrongylus brasiliensis through the lungs of the rat, during primary infection, was studied at 24 h, 72 h and 8 days. At 24 h p.i., there was evidence of damage to lung epithelial cells and microvasculature, with increa... Read More about Anti-inflammatory responses and oxidative stress in Nippostrongylus brasiliensis-induced pulmonary inflammation..

A controlled comparison of eye movement desensitization and reprocessing versus exposure plus cognitive restructuring versus waiting list in the treatment of post-traumatic stress disorder. (2002)
Journal Article
Power, K., McGoldrick, T., Brown, K., Buchanan, R., Sharp, D., Swanson, V., & Karatzias, T. (2002). A controlled comparison of eye movement desensitization and reprocessing versus exposure plus cognitive restructuring versus waiting list in the treatment of post-traumatic stress disorder. Clinical Psychology and Psychotherapy, 9, 299-318. https://doi.org/10.1002/cpp.341

A total of 105 patients with post-traumatic stress disorder (PTSD) were randomly allocated to eye-movement desensitization and reprocessing (EMDR) (n = 39) versus exposure plus cognitive restructuring (E + CR) (n = 37) versus waiting list (WL) (n = 2... Read More about A controlled comparison of eye movement desensitization and reprocessing versus exposure plus cognitive restructuring versus waiting list in the treatment of post-traumatic stress disorder..

Drosophila melanogasterGlutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form (2001)
Journal Article
Fraser, J. A., Saunders, R. D. C., & McLellan, L. I. (2002). Drosophila melanogasterGlutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form. Journal of Biological Chemistry, 277(2), 1158-1165. https://doi.org/10.1074/jbc.m106683200

Glutamate-cysteine ligase (GCL) plays an important role in regulating glutathione homeostasis. In mammals, it comprises a catalytic (GCLC) and modifier (GCLM) subunit. The existence of a modifier subunit in invertebrates has not been described to dat... Read More about Drosophila melanogasterGlutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form.

Aluminium Lactate Treatment of DQ12 Quartz Inhibits Its Ability to Cause Inflammation, Chemokine Expression, and Nuclear Factor-ÎşB Activation (2001)
Journal Article
Duffin, R., Gilmour, P. S., Schins, R. P., Clouter, A., Guy, K., Brown, D. M., MacNee, W., Borm, P. J., Donaldson, K., & Stone, V. (2001). Aluminium Lactate Treatment of DQ12 Quartz Inhibits Its Ability to Cause Inflammation, Chemokine Expression, and Nuclear Factor-ÎşB Activation. Toxicology and Applied Pharmacology, 176(1), 10-17. https://doi.org/10.1006/taap.2001.9268

In 1997, an IARC Working Group classified quartz (crystalline silica) as a Group 1 lung carcinogen, but only in some industries, i.e., the quartz hazard is a variable entity. The reactivity of the quartz surface may underlie its ability to cause infl... Read More about Aluminium Lactate Treatment of DQ12 Quartz Inhibits Its Ability to Cause Inflammation, Chemokine Expression, and Nuclear Factor-ÎşB Activation.

Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish (2001)
Journal Article
Pohl, S., Darlison, M. G., Clarke, W., Lederis, K., & Richter, D. (2001). Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish. European Journal of Pharmacology, 430(2-3), 193-202. https://doi.org/10.1016/S0014-2999%2801%2901391-7

Although it is well established that fish possess corticotropin-releasing factor (CRF) and a CRF-like peptide, urotensin I, comparatively little is known about the pharmacology of their cognate receptors. Here we report the isolation and functional e... Read More about Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish.

Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. (2001)
Journal Article
Brown, D. M., Wilson, M. R., MacNee, W., Stone, V., & Donaldson, K. (2001). Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicology and Applied Pharmacology, 175(3), 191-199. https://doi.org/10.1006/taap.2001.9240

Studies into the effects of ultrafine particles in the lung have shown adverse effects considered to be due in part to the particle size. Air pollution particles (PM10) are associated with exacerbations of respiratory disease and deaths from cardiova... Read More about Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines..

Functional pharmacology of GABAA receptors containing the chicken brain Îł4 subunit (2001)
Journal Article
Forster, I. C., Harvey, R. J., Darlison, M. G., & Benson, J. A. (2001). Functional pharmacology of GABAA receptors containing the chicken brain Îł4 subunit. European Journal of Pharmacology, 419(1), 1-7. https://doi.org/10.1016/S0014-2999%2801%2900964-5

The functional pharmacology of receptors composed of the chicken brain {GABAA} receptor γ4 subunit and the mammalian {GABAA} receptor α3 and β2 subunits was studied by heterologous expression in Xenopus laevis oocytes using the two electrode voltage-... Read More about Functional pharmacology of GABAA receptors containing the chicken brain γ4 subunit.

Influence of Petroleum Hydrocarbon Contamination on Microalgae and Microbial Activities in a Long-Term Contaminated Soil (2000)
Journal Article
Megharaj, M., Singleton, I., McClure, N. C., & Naidu, R. (2000). Influence of Petroleum Hydrocarbon Contamination on Microalgae and Microbial Activities in a Long-Term Contaminated Soil. Archives of Environmental Contamination and Toxicology, 38(4), 439-445. https://doi.org/10.1007/s002449910058

Petroleum hydrocarbons are widespread environmental pollutants. Although biodegradation of petroleum hydrocarbons has been the subject of numerous investigations, information on their toxicity to microorganisms in soil is limited, with virtually no w... Read More about Influence of Petroleum Hydrocarbon Contamination on Microalgae and Microbial Activities in a Long-Term Contaminated Soil.

Chicken GABAA receptor β4 subunits form robust homomeric GABA-gated channels in Xenopus oocytes (1998)
Journal Article
Liu, S.-C., Parent, L., Harvey, R. J., Darlison, M. G., & Eugene, J. M. B. (1998). Chicken GABAA receptor β4 subunits form robust homomeric GABA-gated channels in Xenopus oocytes. European Journal of Pharmacology, 354(2-3), 253-259. https://doi.org/10.1016/S0014-2999%2898%2900453-1

Chicken {GABAA} receptor β4L and β4S subunits were expressed in Xenopus oocytes by cRNA injection. Oocytes expressing either β4 subunit alone or in combination with the chicken α1 subunit were studied using the two-electrode voltage-clamp technique.... Read More about Chicken GABAA receptor β4 subunits form robust homomeric GABA-gated channels in Xenopus oocytes.

Design of hypoxia-targeting radiopharmaceuticals: selective uptake of copper-64 complexes in hypoxic cells in vitro (1998)
Journal Article
Dearling, J. L. J., Lewis, J. S., Mullen, G. E. D., Rae, M. T., Zweit, J., & Blower, P. J. (1998). Design of hypoxia-targeting radiopharmaceuticals: selective uptake of copper-64 complexes in hypoxic cells in vitro. European Journal of Nuclear Medicine and Molecular Imaging, 25(7), 788-792. https://doi.org/10.1007/s002590050283

The well-known perfusion tracer CuPTSM, labelled with 62Cu or 64Cu, is believed to be trapped in cells non-selectively by a bioreductive mechanism. It is proposed that by modifying the ligand to increase its electron donor strength (for example by ad... Read More about Design of hypoxia-targeting radiopharmaceuticals: selective uptake of copper-64 complexes in hypoxic cells in vitro.

A double-blind, placebo-controlled study of tacrine in patients with Alzheimer's disease using SPET (1996)
Journal Article
Prentice, N., Van Beck, M., Dougall, N. J., Moffoot, A. P. R., O'Carroll, R. E., Goodwin, G. M., & Ebmeier, K. P. (1996). A double-blind, placebo-controlled study of tacrine in patients with Alzheimer's disease using SPET. Journal of Psychopharmacology, 10(3), 175-181. https://doi.org/10.1177/026988119601000301

Background: the effect of single-dose and long-term cholinergic enhancement with tacrine on regional cerebral perfusion was examined in patients with Alzheimer's disease using single-photon emission tomography (SPET). Method: 23 patients with probabl... Read More about A double-blind, placebo-controlled study of tacrine in patients with Alzheimer's disease using SPET.

The embryonal carcinoma cell line PCC7-S-AzaR: 21.21: 21.2 (clone 1009) expresses a functional GABA: 21.2A: 21.2 receptor comprising the α5, β3 and γ3 subunits: 21.2 (1995)
Journal Article
Harvey, R. J., Lobron, C., Reinhardt-Maelicke, S., Maelicke, A., & Darlison, M. G. (1995). The embryonal carcinoma cell line PCC7-S-AzaR: 21.21: 21.2 (clone 1009) expresses a functional GABA: 21.2A: 21.2 receptor comprising the α5, β3 and γ3 subunits: 21.2. Behavioural Pharmacology, 6(SUPPLEMENT 1), 119. https://doi.org/10.1097/00008877-199505001-00138

Pharmacology, Cloning and Expression of Insect Nicotinic Acetylcholine Receptors (1988)
Book Chapter
Marshall, J., David, J. A., Darlison, M. G., Barnard, E. A., & Sattelle, D. B. (1988). Pharmacology, Cloning and Expression of Insect Nicotinic Acetylcholine Receptors. In Nicotinic Acetylcholine Receptors in the Nervous System (257-281). Springer. https://doi.org/10.1007/978-3-642-74167-8_20

There is considerable evidence that acetylcholine is an excitatory neurotransmitter at many synapses in the insect central nervous system (Sattelle 1986). Despite the acute technical difficulties of proving that a putative transmitter exerts a functi... Read More about Pharmacology, Cloning and Expression of Insect Nicotinic Acetylcholine Receptors.

Case studies of the indexing and retrieval of pharmacology papers (1988)
Journal Article
Barber, J., Moffat, S., Wood, F., & Bawden, D. (1988). Case studies of the indexing and retrieval of pharmacology papers. Information Processing and Management, 24(2), 141-150. https://doi.org/10.1016/0306-4573%2888%2990106-9

This article reports a detailed analysis of the coverage and indexing of 30 papers on pharmacological topics by BIOSIS, CAsearch, EMbase, and MEDLINE online, and Biological Abstracts, Chemical Abstracts, Excerpta Medica, and Index Medicus printed ver... Read More about Case studies of the indexing and retrieval of pharmacology papers.