The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling

Staines, K. A.; MacRae, V. E.; Farquharson, C.

Abstract

The small integrin-binding ligand N-linked glycoprotein (SIBLING) family consists of osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein. These proteins share many structural characteristics and are primarily located in bone and dentin. Accumulating evidence has implicated the SIBLING proteins in matrix mineralisation. Therefore, in this review, we discuss the individual role that each of the SIBLING proteins has in this highly orchestrated process. In particular, we emphasise how the nature and extent of their proteolytic processing and post-translational modification affect their functional role. Finally, we describe the likely roles of the SIBLING proteins in clinical disorders of hypophosphataemia and their potential therapeutic use.

Citation

Staines, K. A., MacRae, V. E., & Farquharson, C. (2012). The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling. Journal of Endocrinology, 214(3), 241-255. https://doi.org/10.1530/joe-12-0143

• Journal Article Type: Article
• Acceptance Date: Jun 13, 2012
• Online Publication Date: Jun 13, 2012
• Publication Date: Sep 1, 2012
• Deposit Date: Jan 20, 2017
• Journal: Journal of Endocrinology
• Print ISSN: 0022-0795
• Electronic ISSN: 1479-6805
• Publisher: BioScientifica
• Peer Reviewed: Peer Reviewed
• Volume: 214
• Issue: 3
• Pages: 241-255
• DOI: https://doi.org/10.1530/joe-12-0143
• Keywords: Bone, SIBLING proteins, proteolytic processing, hypophosphataemia,
• Public URL: http://researchrepository.napier.ac.uk/Output/466216