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The meaning and management of neuroleptic medication: a study of patients with a diagnosis of schizophrenia (1998)
Journal Article
Rogers, A., Day, J. C., Williams, B., Randall, F., Wood, P., Healy, D., & Bentall, R. P. (1998). The meaning and management of neuroleptic medication: a study of patients with a diagnosis of schizophrenia. Social Science and Medicine, 47(9), 1313-1323. https://doi.org/10.1016/s0277-9536%2898%2900209-3

The meaning of medication and the way in which people use medicines has been the focus of a number of studies in recent years. However, there has been little attention directed to the meaning and management of neuroleptic medication by people who hav... Read More about The meaning and management of neuroleptic medication: a study of patients with a diagnosis of schizophrenia.

Exclusion of linkage between idiopathic generalized epilepsies and the GABAA receptor α1 and γ2 subunit gene cluster on chromosome 5 (1996)
Journal Article
Sander, T., Hildmann, T., Janz, D., Wienker, T. F., Bianchi, A., Bauer, G., Sailer, U., Scaramelli, A., Neitzel, H., Schmitz, B., Bailey, M. E., Beck-Mannagetta, G., Johnson, K. J., & Darlison, M. G. (1996). Exclusion of linkage between idiopathic generalized epilepsies and the GABAA receptor α1 and γ2 subunit gene cluster on chromosome 5. Epilepsy Research, 23(3), 235-244. https://doi.org/10.1016/0920-1211%2895%2900098-4

Hereditary factors play a major role in the etiology of idiopathic generalized epilepsies (IGEs). The pivotal function of ionotropic γ-aminobutyric acid type A receptors (GABRs) in inhibitory neurotransmission in the mammalian central nervous system... Read More about Exclusion of linkage between idiopathic generalized epilepsies and the GABAA receptor α1 and γ2 subunit gene cluster on chromosome 5.

Schizophrenia and GABAA receptor subunit genes (1995)
Journal Article
Byerley, W., Bailey, M. E., Hicks, A. A., Riley, B. P., Darlison, M. G., Holik, J., Hoff, M., Umar, F., Reimherr, F., Wender, P., Myles-Worsley, M., Waldo, M., Freedman, R., Johnson, K. J., & Coon, H. (1995). Schizophrenia and GABAA receptor subunit genes. Psychiatric Genetics, 5(1), 23-30. https://doi.org/10.1097/00041444-199521000-00004

Alterations in γ-aminobutyric acid (GABA) neurotransmission have been indirectly implicated in the pathogenesis of schizophrenia. Using nine multiplex pedigrees, we tested for linkage between schizophrenia and simple sequence repeat polymorphisms for... Read More about Schizophrenia and GABAA receptor subunit genes.

GABAAreceptor subtypes: which, where and why? (1995)
Journal Article
Darlison, M. G., & Albrecht, B. E. (1995). GABAAreceptor subtypes: which, where and why?. Seminars in the neurosciences, 7(2), 115-126. https://doi.org/10.1006/smns.1995.0013

Synaptic inhibition in the vertebrate central nervous system is mediated predominantly by subtypes of the GABAAreceptor, which comprise different pentameric combinations of the products of 13 genes. In this article, we review the results of recent ex... Read More about GABAAreceptor subtypes: which, where and why?.

Isolation and sequence analysis of the chicken GABAa receptor α1-subunit gene promoter (1995)
Journal Article
Bateson, A. N., Ultsch, A., & Darlison, M. G. (1995). Isolation and sequence analysis of the chicken GABAa receptor α1-subunit gene promoter. Gene, 153(2), 243-247. https://doi.org/10.1016/0378-1119%2894%2900776-o

A genomic clone containing the 5'-flanking sequence of the chicken {GABAA} receptor α1-subunit-encoding gene (GabRα1) was isolated and characterized. An intron was found to interrupt the 5'-untranslated region. The transcription start point (tsp) was... Read More about Isolation and sequence analysis of the chicken GABAa receptor α1-subunit gene promoter.

Clonidine infusion increases uptake of 99mTc-Exametazime in anterior cingulate cortex in Korsakoff's psychosis (1994)
Journal Article
Moffoot, A., O'Carroll, R. E., Murray, C., Dougall, N., Ebmeier, K., & Goodwin, G. M. (1994). Clonidine infusion increases uptake of 99mTc-Exametazime in anterior cingulate cortex in Korsakoff's psychosis. Psychological Medicine, 24(01), 53. https://doi.org/10.1017/s0033291700026829

The effects upon regional brain function of infusing either saline or clonidine (1·5μg/kg) has been examined in 18 patients with alcoholic Korsakoff's psychosis using 99mTc-hexamethylpropyleneamineoxime (99mTc-HMPAO or 99mTc-Exametazime) and Single P... Read More about Clonidine infusion increases uptake of 99mTc-Exametazime in anterior cingulate cortex in Korsakoff's psychosis.

Short-term effects of electroconvulsive treatment on the uptake of99mTc-Exametazime into brain in major depression shown with single photon emission tomography (1994)
Journal Article
Scott, A. I. F., Dougall, N., Ross, M., O'Carroll, R. E., Riddle, W., Ebmeier, K. P., & Goodwin, G. M. (1994). Short-term effects of electroconvulsive treatment on the uptake of99mTc-Exametazime into brain in major depression shown with single photon emission tomography. Journal of Affective Disorders, 30(1), 27-34. https://doi.org/10.1016/0165-0327%2894%2990148-1

Fifteen patients with major depression who were being treated with bilateral electroconvulsive treatment (ECT) were investigated before and 45 min after a single ECT using split-dose Single Photon Emission Tomography (SPET or SPECT) with 99mTc-Examet... Read More about Short-term effects of electroconvulsive treatment on the uptake of99mTc-Exametazime into brain in major depression shown with single photon emission tomography.

A single photon emission computerised tomography study of regional brain function underlying verbal memory in patients with Alzheimer-type dementia (1993)
Journal Article
Riddle, W., O'Carroll, R. E., Dougall, N., Van Beck, M., Murray, C., Curran, S. M., Ebmeier, K. P., & Goodwin, G. M. (1993). A single photon emission computerised tomography study of regional brain function underlying verbal memory in patients with Alzheimer-type dementia. British Journal of Psychiatry, 163(2), 166-172. https://doi.org/10.1192/bjp.163.2.166

Ten patients with Alzheimer-type dementia and nine age-matched normal controls were examined with SPECT, using split-dose 99mTc-labelled exametazime. The baseline condition involved repetition of the word 'yes' or 'no'. The activation condition invol... Read More about A single photon emission computerised tomography study of regional brain function underlying verbal memory in patients with Alzheimer-type dementia.

A single photon emission computerised tomography study of regional brain function in elderly patients with major depression and with Alzheimer-type dementia (1993)
Journal Article
Curran, S. M., Murray, C. M., Van Beck, M., Dougall, N., O'Carroll, R. E., Austin, M. P., Ebmeier, K. P., & Goodwin, G. M. (1993). A single photon emission computerised tomography study of regional brain function in elderly patients with major depression and with Alzheimer-type dementia. British Journal of Psychiatry, 163(2), 155-165. https://doi.org/10.1192/bjp.163.2.155

The uptake, at rest, of 99mTc-exametazime into different brain regions was compared using SPECT for 20 elderly subjects with major depressive disorder, 20 with Alzheimer-type dementia, and 30 age-matched normal volunteers. Uptake was referred to calc... Read More about A single photon emission computerised tomography study of regional brain function in elderly patients with major depression and with Alzheimer-type dementia.

Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum (1992)
Journal Article
Austin, M.-P., Dougall, N., Ross, M., Murray, C., O'Carroll, R. E., Moffoot, A., Ebmeier, K. P., & Goodwin, G. M. (1992). Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum. Journal of Affective Disorders, 26(1), 31-43. https://doi.org/10.1016/0165-0327%2892%2990032-2

Forty patients with a major depressive episode were investigated at rest using Single Photon Emission Tomography (SPET or SPECT) with 99mTc-exametazime, an intravenous ligand taken into brain in proportion to regional cerebral blood flow, thereby pro... Read More about Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum.

QALYs in mental health: a case study (1992)
Journal Article
Wilkinson, G., Williams, B., Krekorian, H., McLees, S., & Falloon, I. (1992). QALYs in mental health: a case study. Psychological Medicine, 22(3), 725. https://doi.org/10.1017/S0033291700038162

The applicability of the Charing Cross health indicator (CH-X) to the field of mental health was investigated in a community setting using descriptive statistics and principal components analysis. The CH-X is based on assessments of (i) distress and... Read More about QALYs in mental health: a case study.

A computer-based microworld for the assessment and remediation of sentence processing deficits in aphasia. (1991)
Thesis
Crerar, M. A. A computer-based microworld for the assessment and remediation of sentence processing deficits in aphasia. (Thesis). Edinburgh Napier University. http://researchrepository.napier.ac.uk/id/eprint/4968

This thesis investigates impairments of written sentence comprehension in 14
aphasic adults. The primary purpose of the research was to apply computer
technology to the process of assessment, with the aim of improving diagnostic
precision and ther... Read More about A computer-based microworld for the assessment and remediation of sentence processing deficits in aphasia..