Schizophrenia and GABAA receptor subunit genes

Byerley, W.; Bailey, M. E.S.; Hicks, A. A.; Riley, B. P.; Darlison, M. G.; Holik, J.; Hoff, M.; Umar, F.; Reimherr, F.; Wender, P.; Myles-Worsley, M.; Waldo, M.; Freedman, R.; Johnson, K. J.; Coon, H.

Abstract

Alterations in γ-aminobutyric acid (GABA) neurotransmission have been indirectly implicated in the pathogenesis of schizophrenia. Using nine multiplex pedigrees, we tested for linkage between schizophrenia and simple sequence repeat polymorphisms for the GABAA receptor α1, α2, α4, α5, α6, β1 and β3 subunit genes. Evidence of linkage was not found when assuming either autosomal dominant or autosomal recessive inheritance. The non-parametric sib pair test also did not reveal significant evidence of deviation from expected segregation ratios.

Citation

Byerley, W., Bailey, M. E., Hicks, A. A., Riley, B. P., Darlison, M. G., Holik, J., Hoff, M., Umar, F., Reimherr, F., Wender, P., Myles-Worsley, M., Waldo, M., Freedman, R., Johnson, K. J., & Coon, H. (1995). Schizophrenia and GABAA receptor subunit genes. Psychiatric Genetics, 5(1), 23-30. https://doi.org/10.1097/00041444-199521000-00004

• Journal Article Type: Article
• Acceptance Date: Jan 1, 1995
• Publication Date: 1995
• Deposit Date: Aug 5, 2016
• Journal: Psychiatric Genetics
• Print ISSN: 0955-8829
• Electronic ISSN: 1473-5873
• Publisher: Lippincott, Williams & Wilkins
• Peer Reviewed: Peer Reviewed
• Volume: 5
• Issue: 1
• Pages: 23-30
• DOI: https://doi.org/10.1097/00041444-199521000-00004
• Keywords: Schizophrenia, , Receptor Subunit Genes, Linkage analysis,
• Public URL: http://researchrepository.napier.ac.uk/Output/328110