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Schizophrenia and GABAA receptor subunit genes

Byerley, W.; Bailey, M. E.S.; Hicks, A. A.; Riley, B. P.; Darlison, M. G.; Holik, J.; Hoff, M.; Umar, F.; Reimherr, F.; Wender, P.; Myles-Worsley, M.; Waldo, M.; Freedman, R.; Johnson, K. J.; Coon, H.

Authors

W. Byerley

M. E.S. Bailey

A. A. Hicks

B. P. Riley

M. G. Darlison

J. Holik

M. Hoff

F. Umar

F. Reimherr

P. Wender

M. Myles-Worsley

M. Waldo

R. Freedman

K. J. Johnson

H. Coon



Abstract

Alterations in γ-aminobutyric acid (GABA) neurotransmission have been indirectly implicated in the pathogenesis of schizophrenia. Using nine multiplex pedigrees, we tested for linkage between schizophrenia and simple sequence repeat polymorphisms for the GABAA receptor α1, α2, α4, α5, α6, β1 and β3 subunit genes. Evidence of linkage was not found when assuming either autosomal dominant or autosomal recessive inheritance. The non-parametric sib pair test also did not reveal significant evidence of deviation from expected segregation ratios.

Citation

Byerley, W., Bailey, M. E., Hicks, A. A., Riley, B. P., Darlison, M. G., Holik, J., Hoff, M., Umar, F., Reimherr, F., Wender, P., Myles-Worsley, M., Waldo, M., Freedman, R., Johnson, K. J., & Coon, H. (1995). Schizophrenia and GABAA receptor subunit genes. Psychiatric Genetics, 5(1), 23-30. https://doi.org/10.1097/00041444-199521000-00004

Journal Article Type Article
Acceptance Date Jan 1, 1995
Publication Date 1995
Deposit Date Aug 5, 2016
Journal Psychiatric Genetics
Print ISSN 0955-8829
Electronic ISSN 1473-5873
Publisher Lippincott, Williams & Wilkins
Peer Reviewed Peer Reviewed
Volume 5
Issue 1
Pages 23-30
DOI https://doi.org/10.1097/00041444-199521000-00004
Keywords Schizophrenia, , Receptor Subunit Genes, Linkage analysis,
Public URL http://researchrepository.napier.ac.uk/Output/328110




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