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GABAAreceptor subtypes: which, where and why?

Darlison, Mark G.; Albrecht, Barbara E.

Authors

Mark G. Darlison

Barbara E. Albrecht



Abstract

Synaptic inhibition in the vertebrate central nervous system is mediated predominantly by subtypes of the GABAAreceptor, which comprise different pentameric combinations of the products of 13 genes. In this article, we review the results of recent experiments that are helping to define binding-site determinants, on GABAAreceptors, for various ligands and some clinically-important modulators. New and sometimes conflicting data, on the polypeptide compositions of native subtypes, will also be discussed. Studies such as those described here should ultimately lead to a molecular understanding of receptor–ligand interactions, and the biological basis for the large number of subtypes that appear to exist in brain

Citation

Darlison, M. G., & Albrecht, B. E. (1995). GABAAreceptor subtypes: which, where and why?. Seminars in the neurosciences, 7(2), 115-126. https://doi.org/10.1006/smns.1995.0013

Journal Article Type Article
Acceptance Date Apr 1, 1995
Publication Date 1995-04
Deposit Date Aug 1, 2016
Journal Seminars in Neuroscience
Electronic ISSN 1044-5765
Peer Reviewed Peer Reviewed
Volume 7
Issue 2
Pages 115-126
DOI https://doi.org/10.1006/smns.1995.0013
Keywords GABAa receptor, GABAc receptor, ligand-binding site, neuronal inhibition, receptor subtype composition,
Public URL http://researchrepository.napier.ac.uk/Output/321037






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