The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy (2019)
Journal Article
Biskou, O., Casanova, V., Hooper, K., Kemp, S., Wright, G. P., Satsangi, J., Barlow, P., & Stevens, C. (2019). The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy. PLOS ONE, 14(1), e0209665. https://doi.org/10.1371/journal.pone.0209665

The cytoskeletal protein vimentin plays a key role in positioning of organelles within the cytosol and has been linked to the regulation of numerous cellular processes including autophagy, however, how vimentin regulates autophagy remains relatively... Read More about The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy.

Antiviral therapeutic approaches for human rhinovirus infections (2018)
Journal Article
Casanova, V., Sousa, F. H., Stevens, C., & Barlow, P. G. (2018). Antiviral therapeutic approaches for human rhinovirus infections. Future Virology. https://doi.org/10.2217/fvl-2018-0016

Human rhinoviruses (RV) are the primary etiological agent of the common cold. This infection can be mild and self-limiting in immunocompetent hosts, but can be associated with bronchiolitis in infants, pneumonia in the immunosuppressed, and exacerba... Read More about Antiviral therapeutic approaches for human rhinovirus infections.

Cathelicidins display conserved direct antiviral activity towards rhinovirus. (2017)
Journal Article
Sousa, F. H., Casanova, V., Findlay, F., Stevens, C., Svoboda, P., Pohl, J., Proudfoot, L., & Barlow, P. G. (2017). Cathelicidins display conserved direct antiviral activity towards rhinovirus. Peptides, 95, 76-83. https://doi.org/10.1016/j.peptides.2017.07.013

Human rhinoviruses (HRVs) are the most common cause of viral respiratory tract infections, and are associated with significant morbidity and mortality in immunocompromised individuals and patients with pre-existing pulmonary conditions. The therapeut... Read More about Cathelicidins display conserved direct antiviral activity towards rhinovirus..

Design and evaluation of novel theranostic fluorogenic dual probe-prodrug in cancer (2016)
Presentation / Conference Contribution
Mathur, S., Mincher, D., Turnbull, A., Stevens, C., & Poole, A. (n.d.). Design and evaluation of novel theranostic fluorogenic dual probe-prodrug in cancer [Conference Abstract]. https://doi.org/10.1016/s0959-8049%2816%2961501-0

Background: In spite of major advances in the diagnosis and treatment of cancer, there remains a paucity of biomarkers for early detection. Legumain is a potential cancer biomarker and a molecular target for imaging and drug targeting. Legumain is a... Read More about Design and evaluation of novel theranostic fluorogenic dual probe-prodrug in cancer.

Inflammatory Bowel Disease Drugs: A Focus on Autophagy (2016)
Journal Article
Hooper, K. M., Barlow, P. G., Stevens, C., & Henderson, P. (2017). Inflammatory Bowel Disease Drugs: A Focus on Autophagy. Journal of Crohn's and Colitis, 11(1), 118-127. https://doi.org/10.1093/ecco-jcc/jjw127

Inflammatory bowel disease [IBD] is characterized by chronic inflammation of the gastrointestinal tract. Medications such as corticosteroids, thiopurines, immunomodulators and biologic agents are used to induce and maintain remission; however, respon... Read More about Inflammatory Bowel Disease Drugs: A Focus on Autophagy.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). (2016)
Journal Article
Baghdiguian, S., Bagniewska-Zadworna, A., Baek, S.-H., Baehrecke, E. H., Bae, S. H., Bae, D.-H., Bae, J., Backer, J. M., Azad, N., Bachetti, T., Awale, S., Avantaggiati, M. L., Avrahami, L., Avagliano, L., Autelli, R., Auburger, G., Aurelian, L., Auberger, P., Attardi, L. D., …Stevens, C. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12(1), 1-222. https://doi.org/10.1080/15548627.2015.1100356

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies... Read More about Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)..

PWE-090 the effect of commonly used Ibd drugs on autophagy induction using an in vitro cell culture system. (2014)
Journal Article
Henderson, P., Satsangi, J., Wilson, D., & Stevens, C. (2014). PWE-090 the effect of commonly used Ibd drugs on autophagy induction using an in vitro cell culture system. Gut, 63(Suppl 1), A163. https://doi.org/10.1136/gutjnl-2014-307263.350

Introduction Genome wide association studies and functional experiments in inflammatory bowel disease (IBD) have delineated the importance of autophagy in IBD pathogenesis. We aimed to determine the effect of commonly utilised IBD drugs on autophagy... Read More about PWE-090 the effect of commonly used Ibd drugs on autophagy induction using an in vitro cell culture system..

A role for vimentin in Crohn disease (2012)
Journal Article
Henderson, P., Wilson, D. C., Satsangi, J., & Stevens, C. (2012). A role for vimentin in Crohn disease. Autophagy, 8(11), 1695-1696. https://doi.org/10.4161/auto.21690

Crohn disease (CD), one of the major chronic inflammatory bowel diseases, occurs anywhere in the gastrointestinal tract with discontinuous transmural inflammation. A number of studies have now demonstrated that genetic predisposition, environmental... Read More about A role for vimentin in Crohn disease.

The Role of Autophagy in Crohn’s Disease (2012)
Journal Article
Henderson, P., & Stevens, C. (2012). The Role of Autophagy in Crohn’s Disease. Cells, 1(3), 492-519. https://doi.org/10.3390/cells1030492

(Macro)-autophagy is a homeostatic process by which eukaryotic cells dispose of protein aggregates and damaged organelles. Autophagy is also used to degrade micro-organisms that invade intracellularly in a process termed xenophagy. Genome-wide associ... Read More about The Role of Autophagy in Crohn’s Disease.

TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's Disease (2011)
Journal Article
Nimmo, E. R., Stevens, C., Phillips, A. M., Smith, A., Drummond, H. E., Noble, C. L., Quail, M., Davies, G., Aldhous, M. C., Wilson, D. C., & Satsangi, J. (2011). TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's Disease. Gastroenterology, 141(3), 972-981.e2. https://doi.org/10.1053/j.gastro.2011.05.043

Background & Aims The mechanisms by which specific mutations in NOD2/CARD15 increase the risk for Crohn's disease (CD) are unclear. We identified proteins that interact with {NOD2} and investigated them by expression, genetic, and functional analyses... Read More about TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's Disease.

Autophagy: from basic science to clinical application (2009)
Journal Article
Van Limbergen, J., Stevens, C., Nimmo, E. R., Wilson, D. C., & Satsangi, J. (2009). Autophagy: from basic science to clinical application. Mucosal immunology, 2(4), 315-330. https://doi.org/10.1038/mi.2009.20

Autophagy is a cellular pathway involved in protein and organelle degradation, which is likely to represent an innate adaptation to starvation. In times of nutrient deficiency, the cell can self-digest and recycle some nonessential components through... Read More about Autophagy: from basic science to clinical application.