Antiviral therapeutic approaches for human rhinovirus infections

Casanova, Victor; Sousa, Filipa H; Stevens, Craig; Barlow, Peter G

Abstract

Human rhinoviruses (RV) are the primary etiological agent of the common cold. This infection can be mild and self-limiting in immunocompetent hosts, but can be associated with bronchiolitis in infants, pneumonia in the immunosuppressed, and exacerbations of pre-existing pulmonary conditions such as asthma or chronic obstructive pulmonary disease. Many of these conditions can place significant economic costs upon healthcare infrastructure. There is currently no licenced vaccine for rhinovirus, as the large variety of RV serotypes has posed significant challenges for research. In this review we discuss current knowledge around antiviral drugs and small molecule inhibitors of rhinovirus infection, as well as antiviral host defence peptides as exciting prospects to approach the development of novel therapeutics which target human rhinovirus.

Citation

Casanova, V., Sousa, F. H., Stevens, C., & Barlow, P. G. (2018). Antiviral therapeutic approaches for human rhinovirus infections. Future Virology, https://doi.org/10.2217/fvl-2018-0016

• Journal Article Type: Review
• Acceptance Date: Apr 20, 2018
• Online Publication Date: Jun 12, 2018
• Publication Date: Jun 12, 2018
• Deposit Date: May 17, 2018
• Publicly Available Date: May 17, 2018
• Journal: Future Virology
• Print ISSN: 1746-0794
• Electronic ISSN: 1746-0808
• Publisher: Future Medicine
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.2217/fvl-2018-0016
• Keywords: rhinovirus, peptide, antiviral drugs, cathelicidin, interferon, vitamin D
• Public URL: http://researchrepository.napier.ac.uk/Output/1185214
• Contract Date: May 17, 2018