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The Role of Autophagy in Crohn’s Disease

Henderson, Paul; Stevens, Craig


Paul Henderson


(Macro)-autophagy is a homeostatic process by which eukaryotic cells dispose of protein aggregates and damaged organelles. Autophagy is also used to degrade micro-organisms that invade intracellularly in a process termed xenophagy. Genome-wide association scans have recently identified autophagy genes as conferring susceptibility to Crohn’s disease (CD), one of the chronic inflammatory bowel diseases, with evidence suggesting that CD arises from a defective innate immune response to enteric bacteria. Here we review the emerging role of autophagy in CD, with particular focus on xenophagy and enteric E. coli strains with an adherent and invasive phenotype that have been consistently isolated from CD patients with ileal disease.


Henderson, P., & Stevens, C. (2012). The Role of Autophagy in Crohn’s Disease. Cells, 1(3), 492-519.

Journal Article Type Article
Acceptance Date Jul 23, 2012
Online Publication Date Aug 3, 2012
Publication Date Aug 3, 2012
Deposit Date Jul 27, 2016
Publicly Available Date Jul 28, 2016
Journal Cells
Electronic ISSN 2073-4409
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 1
Issue 3
Pages 492-519
Keywords autophagy; Crohn’s disease; inflammatory bowel disease; ATG16L1; NOD2; IRGM
Public URL


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