The Role of Autophagy in Crohn’s Disease

Henderson, Paul; Stevens, Craig

Abstract

(Macro)-autophagy is a homeostatic process by which eukaryotic cells dispose of protein aggregates and damaged organelles. Autophagy is also used to degrade micro-organisms that invade intracellularly in a process termed xenophagy. Genome-wide association scans have recently identified autophagy genes as conferring susceptibility to Crohn’s disease (CD), one of the chronic inflammatory bowel diseases, with evidence suggesting that CD arises from a defective innate immune response to enteric bacteria. Here we review the emerging role of autophagy in CD, with particular focus on xenophagy and enteric E. coli strains with an adherent and invasive phenotype that have been consistently isolated from CD patients with ileal disease.

Citation

Henderson, P., & Stevens, C. (2012). The Role of Autophagy in Crohn’s Disease. Cells, 1(3), 492-519. https://doi.org/10.3390/cells1030492

• Journal Article Type: Article
• Acceptance Date: Jul 23, 2012
• Online Publication Date: Aug 3, 2012
• Publication Date: Aug 3, 2012
• Deposit Date: Jul 27, 2016
• Publicly Available Date: Jul 28, 2016
• Journal: Cells
• Electronic ISSN: 2073-4409
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 1
• Issue: 3
• Pages: 492-519
• DOI: https://doi.org/10.3390/cells1030492
• Keywords: autophagy; Crohn’s disease; inflammatory bowel disease; ATG16L1; NOD2; IRGM
• Public URL: http://researchrepository.napier.ac.uk/Output/318576