A role for vimentin in Crohn disease

Henderson, Paul; Wilson, David C.; Satsangi, Jack; Stevens, Craig

Abstract

Crohn disease (CD), one of the major chronic inflammatory bowel diseases, occurs anywhere in the gastrointestinal tract with discontinuous transmural inflammation. A number of studies have now demonstrated that genetic predisposition, environmental influences and a dysregulated immune response to the intestinal microflora are involved. Major CD susceptibility pathways uncovered through genome-wide association studies strongly implicate the innate immune response (NOD2), in addition to the more specific acquired T cell response (IL23R, ICOSLG) and autophagy (ATG16L1, IRGM). Examination of the disease-associated microbiome, although complex, has identified several potentially contributory microorganisms, most notably adherent-invasive E.coli strains (AIEC), which have been isolated by independent investigators in both adult and pediatric CD patients. Here we discuss our recent finding that the type-III intermediate filament (IF) protein VIM/vimentin is a novel NOD2 interacting protein that regulates NOD2 activities including inflammatory NFKB1 signaling, autophagy and bacterial handling.

Citation

Henderson, P., Wilson, D. C., Satsangi, J., & Stevens, C. (2012). A role for vimentin in Crohn disease. Autophagy, 8(11), 1695-1696. https://doi.org/10.4161/auto.21690

• Journal Article Type: Article
• Acceptance Date: Aug 1, 2012
• Online Publication Date: Aug 28, 2012
• Publication Date: Aug 28, 2012
• Deposit Date: Jul 27, 2016
• Journal: Autophagy
• Print ISSN: 1554-8627
• Electronic ISSN: 1554-8635
• Publisher: Taylor & Francis
• Peer Reviewed: Peer Reviewed
• Volume: 8
• Issue: 11
• Pages: 1695-1696
• DOI: https://doi.org/10.4161/auto.21690
• Keywords: Crohn disease, NOD2, vimentin, AIEC, autophagy
• Public URL: http://researchrepository.napier.ac.uk/Output/318074