A double-blind, placebo-controlled study of tacrine in patients with Alzheimer's disease using SPET

Prentice, Neil; Van Beck, Margaret; Dougall, Nadine J.; Moffoot, Anthony P. R.; O'Carroll, Ronan E.; Goodwin, Guy M.; Ebmeier, Klaus P.

Abstract

Background: the effect of single-dose and long-term cholinergic enhancement with tacrine on regional cerebral perfusion was examined in patients with Alzheimer's disease using single-photon emission tomography (SPET). Method: 23 patients with probable Alzheimer's disease (DSM-III-R and NINCDS-ADRDA criteria) were scanned before and after a single oral dose of tacrine at the start of the study and again after 12 weeks of randomized, double-blind treatment with tacrine or placebo, using high resolution 99mTc-Exametazime SPET. Patients also underwent neuropsychological testing with the CAMCOG, the Mini-Mental State Examination and the Rivermead Behavioural Memory Test before and after 12 weeks of treatment. Results: occipital count ratios in all regions of interest declined by 3% over 12 weeks, indicating a progression of the disease. Acute tacrine challenge resulted in a 16% increase in the superior frontal and a 11% decrease in the anterior temporal cortex. The acute effects of tacrine were modified by 12 weeks of treatment, particularly in the medial frontal (cingulate) cortex where active treatment was associated with a reduced acute tacrine response. There were no changes in cognitive function associated with active treatment. Conclusion: the study demonstrates the sensitivity of cerebral perfusion measures to changes during acute and medium-term tacrine treatment.

Citation

Prentice, N., Van Beck, M., Dougall, N. J., Moffoot, A. P. R., O'Carroll, R. E., Goodwin, G. M., & Ebmeier, K. P. (1996). A double-blind, placebo-controlled study of tacrine in patients with Alzheimer's disease using SPET. Journal of Psychopharmacology, 10(3), 175-181. https://doi.org/10.1177/026988119601000301

• Journal Article Type: Article
• Acceptance Date: Jan 1, 1996
• Publication Date: 1996-05
• Deposit Date: Sep 30, 2016
• Journal: Journal of Psychopharmacology
• Print ISSN: 0269-8811
• Electronic ISSN: 1461-7285
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 3
• Pages: 175-181
• DOI: https://doi.org/10.1177/026988119601000301
• Keywords: Pharmacology (medical); Pharmacology; Psychiatry and Mental health
• Public URL: http://researchrepository.napier.ac.uk/Output/396441