Free-CoA mediated regulation of intermediary and central metabolism: An hypothesis, which accounts for the excretion of α-ketoglutarate during aerobic growth of E. coli on acetate (2005)
Journal Article
El-Mansi, M. (2005). Free-CoA mediated regulation of intermediary and central metabolism: An hypothesis, which accounts for the excretion of α-ketoglutarate during aerobic growth of E. coli on acetate. Research in Microbiology, 156(8), 874-879. https://doi.org/10.1016/j.resmic.2005.04.008

During growth of Escherichia coli on acetate, phosphotransacetylase and -ketoglutarate dehydrogenase are in direct competition for their common co-factor, HS-CoA. Such competition is resolved in favour of phosphotransacetylase, thus rendering -ketogl... Read More about Free-CoA mediated regulation of intermediary and central metabolism: An hypothesis, which accounts for the excretion of α-ketoglutarate during aerobic growth of E. coli on acetate.

Oxoazabenzo[de]anthracenes conjugated to Amino Acids: Synthesis and evaluation as DNA-binding antitumor agents. (2005)
Journal Article
Dias, N., Goossens, J.-F., Baldeyrou, B., Lansiaux, A., Colson, P., Di Salvo, A., Bernal, J., Turnbull, A., Mincher, D., & Bailly, C. (2005). Oxoazabenzo[de]anthracenes conjugated to Amino Acids: Synthesis and evaluation as DNA-binding antitumor agents. Bioconjugate Chemistry, 16(4), 949-958. https://doi.org/10.1021/bc050065x

We report the synthesis of an original series of oxoazabenzo[de]anthracenes conjugated to an amino acid: Ala, Phe, Pro, Lys, or Gly (4a-e, respectively). The compounds, derived from 1,8-dihydroxyanthracene-9,10-dione, were studied for DNA binding and... Read More about Oxoazabenzo[de]anthracenes conjugated to Amino Acids: Synthesis and evaluation as DNA-binding antitumor agents..

Evidence for the presence of an alternative glucose transport system in Clostridium beijerinckii NCIMB 8052 and the solvent hyper-producing mutant BA101. (2005)
Journal Article
Lee, J., Mitchell, W. J., Tangney, M., & Blaschek, H. P. (2005). Evidence for the presence of an alternative glucose transport system in Clostridium beijerinckii NCIMB 8052 and the solvent hyper-producing mutant BA101. Applied and Environmental Microbiology, 71, 3384-3387. https://doi.org/10.1128/AEM.71.6.3384-3387.2005

The effects of substrate analogs and energy inhibitors on glucose uptake and phosphorylation by Clostridium beijerinckii provide evidence for the operation of two uptake systems: a previously characterized phosphoenolpyruvate-dependent phosphotransfe... Read More about Evidence for the presence of an alternative glucose transport system in Clostridium beijerinckii NCIMB 8052 and the solvent hyper-producing mutant BA101..

The effect of refurbishing a UK steel plant on PM10 metal composition and ability to induce inflammation (2005)
Journal Article
Hutchison, G. R., Brown, D. M., Hibbs, L. R., Heal, M. R., Donaldson, K., Maynard, R. L., Monaghan, M., Nicholl, A., & Stone, V. (2005). The effect of refurbishing a UK steel plant on PM10 metal composition and ability to induce inflammation. Respiratory Research, 6(1), 43. https://doi.org/10.1186/1465-9921-6-43

In the year 2000 Corus closed its steel plant operations in Redcar, NE of England temporarily for refurbishment of its blast furnace. This study investigates the impact of the closure on the chemical composition and biological activity of PM10 collec... Read More about The effect of refurbishing a UK steel plant on PM10 metal composition and ability to induce inflammation.

Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas (2005)
Journal Article
Gubbay, O., Guo, W., Rae, M. T., Niven, D., Langdon, S. P., & Hillier, S. G. (2005). Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas. British Journal of Cancer, 92, 1927-1933. https://doi.org/10.1038/sj.bjc.6602568

Ovulation is believed to contribute to the development of ovarian cancers that derive from the ovarian surface epithelium (OSE). The process of ovulation is synonymous with inflammation and inflammatory cytokines such as interleukin-1α (IL-1α) have r... Read More about Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas.

Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo. (2005)
Journal Article
Taylor, M. D., LeGoff, L., Harris, A., Malone, E. M., Allen, J. E., & Maizels, R. M. (2005). Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo. Journal of Immunology, 174, 4924-4933

Human filarial parasites cause chronic infection associated with long-term down-regulation of the host’s immune response. We show here that CD4+ T cell regulation is the main determinant of parasite survival. In a laboratory model of infection, using... Read More about Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo..

Perivascular nerves induce cardiorespiratory reflexes in response to algogens in anaesthetised rats (2004)
Journal Article
Smith, P. J. W., & McQueen, D. S. (2004). Perivascular nerves induce cardiorespiratory reflexes in response to algogens in anaesthetised rats. Neuroscience Research, 50(3), 271-281. https://doi.org/10.1016/j.neures.2004.07.006

In the present study we measured cardiovascular and respiratory reflexes evoked by administration of bradykinin and capsaicin into the hindlimb vasculature of anaesthetised rats, whilst simultaneously recording activity of sensory afferents on the ad... Read More about Perivascular nerves induce cardiorespiratory reflexes in response to algogens in anaesthetised rats.

Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis. (2004)
Journal Article
Rae, M. T., Niven, D., Ross, A., Forster, T., Lathe, R., Critchley, H. O. D., Ghazal, P., & Hillier, S. G. (2004). Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis. Journal of Endocrinology, 183, 19-28. https://doi.org/10.1677/joe.1.05754

The human ovarian surface epithelium (HOSE) is a common site of gynaecological disease including endometriosis and ovarian cancer, probably due to serial injury-repair events associated with successive ovulations. To comprehend the importance of ster... Read More about Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis..

Antiinflammatory Steroid Action in Human Ovarian Surface Epithelial Cells (2004)
Journal Article
Hillier, S. G., Rae, M. T., Niven, D., Critchley, H. O. D., & Harlow, C. R. (2004). Antiinflammatory Steroid Action in Human Ovarian Surface Epithelial Cells. Journal of Clinical Endocrinology and Metabolism, 89(9), 4538-4544. https://doi.org/10.1210/jc.2003-032225

The human ovarian surface epithelium (OSE) is subject to
serial injury and repair during ovulation, which is a natural inflammatory event. We asked whether there is a compensatory antiinflammatory component to this process, involving steroid hormone... Read More about Antiinflammatory Steroid Action in Human Ovarian Surface Epithelial Cells.

Flux to acetate and lactate excretions in industrial fermentations: physiological and biochemical implications (2004)
Journal Article
El-Mansi, M. (2004). Flux to acetate and lactate excretions in industrial fermentations: physiological and biochemical implications. Journal of Industrial Microbiology and Biotechnology, 31(7), 295-300. https://doi.org/10.1007/s10295-004-0149-2

The efficiency of carbon conversion to biomass and desirable end products in industrial fermentations is diminished by the diversion of carbon to acetate and lactate excretions. In this study, the use of prototrophic and mutant strains of Escherichia... Read More about Flux to acetate and lactate excretions in industrial fermentations: physiological and biochemical implications.

Cannabidiol lacks the vanilloid VR1-mediated vasorespiratory effects of capsaicin and anandamide in anaesthetised rats (2004)
Journal Article
McQueen, D. S., Bond, S. M., Smith, P. J., Balali-Mood, K., & Smart, D. (2004). Cannabidiol lacks the vanilloid VR1-mediated vasorespiratory effects of capsaicin and anandamide in anaesthetised rats. European Journal of Pharmacology, 491(2-3), 181-189. https://doi.org/10.1016/j.ejphar.2004.03.045

The results of vasorespiratory studies in rats anaesthetised with pentobarbital show that (±) cannabidiol, a cannabinoid that lacks psychotropic actions and is inactive at cannabinoid (CB) receptors, does not affect respiration or blood pressure when... Read More about Cannabidiol lacks the vanilloid VR1-mediated vasorespiratory effects of capsaicin and anandamide in anaesthetised rats.

The emerging role of E2F-1 in the DNA damage response and checkpoint control. (2004)
Journal Article
Stevens, C., & La Thangue, N. B. (2004). The emerging role of E2F-1 in the DNA damage response and checkpoint control. DNA Repair, 3(8-9), 1071-1079. https://doi.org/10.1016/j.dnarep.2004.03.034

Genotoxic stress triggers a myriad of cellular responses including cell cycle arrest, stimulation of {DNA} repair and apoptosis. A central role for the E2F-1 transcription factor in the {DNA} damage response pathway is gaining support. E2F-1 is phosp... Read More about The emerging role of E2F-1 in the DNA damage response and checkpoint control..

Biochemistry of topoisomerase inhibtion and cellular mechanisms of anthraquinone-amino acid conjugates in vitro. (2004)
Thesis
Pettersson, S. Biochemistry of topoisomerase inhibtion and cellular mechanisms of anthraquinone-amino acid conjugates in vitro. (Thesis). Edinburgh Napier University. http://researchrepository.napier.ac.uk/id/eprint/4160

Antioxidant and cytoprotective responses to redox stress (2004)
Journal Article
Mathers, J., Fraser, J. A., McMahon, M., Saunders, R. D. C., Hayes, J. D., & McLellan, L. I. (2004). Antioxidant and cytoprotective responses to redox stress. Biochemical Society symposia, 71, 157-176. https://doi.org/10.1042/bss0710157

Aerobic cells produce reactive oxygen species as a consequence of normal cellular metabolism, and an array of antioxidant systems are in place to maintain the redox balance. When the redox equilibrium of the cell is upset by pro-oxidant environmental... Read More about Antioxidant and cytoprotective responses to redox stress.

Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles (2004)
Journal Article
Brown, D. M., Donaldson, K., Borm, P. J., Schins, R. P., Dehnhardt, M., Gilmour, P., Jimenez, L. A., & Stone, V. (2004). Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles. American Journal of Physiology - Lung Cellular and Molecular Physiology, 286(2), L344-L353. https://doi.org/10.1152/ajplung.00139.2003

Ultrafine (Uf) particles are a component of particulate air pollution suggested to be responsible for the health effects associated with elevations of this pollutant. We have previously suggested that Uf particles, through the induction of oxidative... Read More about Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles.

Expression of C-Reactive Protein in Human Lung Epithelial Cells and Upregulation by Cytokines and Carbon Particles (2004)
Journal Article
Ramage, L., Proudfoot, L., & Guy, K. (2004). Expression of C-Reactive Protein in Human Lung Epithelial Cells and Upregulation by Cytokines and Carbon Particles. Inhalation Toxicology, 16(9), 607-613. https://doi.org/10.1080/08958370490464599

C-reactive protein (CRP) is the prototypic human acute-phase protein and is found at increased levels in the blood during episodes of inflammation. CRP was generally thought to be produced only by hepatocytes; however, several studies have shown extr... Read More about Expression of C-Reactive Protein in Human Lung Epithelial Cells and Upregulation by Cytokines and Carbon Particles.

Expression of C-Reactive Protein and Heat-Shock Protein-70 in the Lung Epithelial Cell Line A549, in Response to PM10 Exposure (2004)
Journal Article
Ramage, L., & Guy, K. (2004). Expression of C-Reactive Protein and Heat-Shock Protein-70 in the Lung Epithelial Cell Line A549, in Response to PM10 Exposure. Inhalation Toxicology, 16(6-7), 447-452. https://doi.org/10.1080/08958370490439614

Increased levels of C-reactive protein (CRP) and heat-shock protein-70 (Hsp70) in plasma are known to be associated with an increased risk of cardiovascular disease. In this study we have investigated the effects of environmental air pollution partic... Read More about Expression of C-Reactive Protein and Heat-Shock Protein-70 in the Lung Epithelial Cell Line A549, in Response to PM10 Exposure.

The influence of changes in nitrogen: silicon ratios on diatom growth dynamics (2004)
Journal Article
Gilpin, L., Davidson, K., & Roberts, E. (2004). The influence of changes in nitrogen: silicon ratios on diatom growth dynamics. Journal of Sea Research, 51(1), 21-35. https://doi.org/10.1016/j.seares.2003.05.005

Nitrate loading to coastal waters has increased over recent decades while silicon loading has remained relatively constant or decreased. As the N:Si ratio in coastal waters shifts due to these anthropogenic influences, silicate limitation of diatom b... Read More about The influence of changes in nitrogen: silicon ratios on diatom growth dynamics.

The Structure of Escherichia coli ATP-phosphoribosyltransferase: Identification of Substrate Binding Sites and Mode of AMP Inhibition (2003)
Journal Article
Lohkamp, B., McDermott, G., Campbell, S. A., Coggins, J. R., & Lapthorn, A. J. (2004). The Structure of Escherichia coli ATP-phosphoribosyltransferase: Identification of Substrate Binding Sites and Mode of AMP Inhibition. Journal of Molecular Biology, 336(1), 131-144. https://doi.org/10.1016/j.jmb.2003.12.020

ATP-phosphoribosyltransferase (ATP-PRT), the first enzyme of the histidine pathway, is a complex allosterically regulated enzyme, which controls the flow of intermediates through this biosynthetic pathway. The crystal structures of Escherichia coli A... Read More about The Structure of Escherichia coli ATP-phosphoribosyltransferase: Identification of Substrate Binding Sites and Mode of AMP Inhibition.

Cellular responses of developing Fucus serratus embryos exposed to elevated concentrations of Cu2+. (2003)
Journal Article
Nielsen, H. D., Brown, M. T., & Brownlee, C. (2003). Cellular responses of developing Fucus serratus embryos exposed to elevated concentrations of Cu2+. Plant, Cell and Environment, 26(10), 1737-1747. https://doi.org/10.1046/j.1365-3040.2003.01091.x

Elevated concentrations of Cu2+ can have inhibitory effects on early development in plants and algae by targeting specific cellular processes. In the present study the effects of elevated Cu2+ on developmental processes in embryos of the brown algae... Read More about Cellular responses of developing Fucus serratus embryos exposed to elevated concentrations of Cu2+..