The emerging role of E2F-1 in the DNA damage response and checkpoint control.

Stevens, Craig; La Thangue, Nicholas B.

Abstract

Genotoxic stress triggers a myriad of cellular responses including cell cycle arrest, stimulation of {DNA} repair and apoptosis. A central role for the E2F-1 transcription factor in the {DNA} damage response pathway is gaining support. E2F-1 is phosphorylated by {DNA} damage responsive protein kinases, which leads to E2F-1 accumulation and the induction of apoptosis. In addition, emerging information suggests that E2F-1 may play a role in the detection and subsequent repair of damaged DNA.

• Journal Article Type: Article
• Online Publication Date: Apr 22, 2004
• Publication Date: 2004-08
• Deposit Date: Aug 2, 2016
• Journal: DNA Repair
• Print ISSN: 1568-7864
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 3
• Issue: 8-9
• Pages: 1071-1079
• DOI: https://doi.org/10.1016/j.dnarep.2004.03.034
• Keywords: E2F-1DNA, repair, DNA damage,
• Public URL: http://researchrepository.napier.ac.uk/Output/322294
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S1568786404001065