Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity (2016)
Journal Article
Poulet, B., Liu, K., Plumb, D., Vo, P., Shah, M., Staines, K., Sampson, A., Nakamura, H., Nagase, H., Carriero, A., Shefelbine, S., Pitsillides, A. A., & Bou-Gharios, G. (2016). Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity. PLOS ONE, 11(12), Article e0167971. https://doi.org/10.1371/journal.pone.0167971

Bone development and length relies on the growth plate formation, which is dependent on degradative enzymes such as MMPs. Indeed, deletion of specific members of this enzyme family in mice results in important joint and bone abnormalities, suggesting... Read More about Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity.

Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila (2016)
Journal Article
Niccoli, T., Cabecinha, M., Tillmann, A., Kerr, F., Wong, C., Cardenes, D., Vincent, A., Bettedi, L., Li, L., Grönke, S., Dols, J., & Partridge, L. (2016). Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila. Current Biology, 26(17), 2291-2300. https://doi.org/10.1016/j.cub.2016.07.017

Glucose hypometabolism is a prominent feature of the brains of patients with Alzheimer's disease (AD). Disease progression is associated with a reduction in glucose transporters in both neurons and endothelial cells of the blood-brain barrier. Howeve... Read More about Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila.

PP2ACdc55’s role in reductional chromosome segregation during achiasmate meiosis in budding yeast is independent of its FEAR function (2016)
Journal Article
Kerr, G. W., Wong, J. H., & Arumugam, P. (2016). PP2ACdc55’s role in reductional chromosome segregation during achiasmate meiosis in budding yeast is independent of its FEAR function. Scientific Reports, 6(1), Article 30397. https://doi.org/10.1038/srep30397

PP2ACdc55 is a highly conserved serine-threonine protein phosphatase that is involved in diverse cellular processes. In budding yeast, meiotic cells lacking PP2ACdc55 activity undergo a premature exit from meiosis I which results in a failure to form... Read More about PP2ACdc55’s role in reductional chromosome segregation during achiasmate meiosis in budding yeast is independent of its FEAR function.

Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion (2016)
Journal Article
Ramaswamy, S., McNeilly, A. S., Rae, M. T., Ramaswamy, S., Grace, C., Mattei, A. A., Siemienowicz, K., Brownlee, W., MacCallum, J., McNeilly, A. S., Duncan, W. C., & Rae, M. T. (2016). Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion. Scientific Reports, 6(1), Article 27408. https://doi.org/10.1038/srep27408

Exogenous androgenic steroids applied to pregnant sheep programmes a PCOS-like phenotype in female offspring. Via ultrasound guidance we applied steroids directly to ovine fetuses at d62 and d82 of gestation, and examined fetal (day 90 gestation) and... Read More about Developmental programming of polycystic ovary syndrome (PCOS): prenatal androgens establish pancreatic islet α/β cell ratio and subsequent insulin secretion.

Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections (2016)
Journal Article
Findlay, F., Proudfoot, L., Stevens, C., & Barlow, P. G. (2016). Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections. Pathogens and Global Health, 110(4-5), 137-147. https://doi.org/10.1080/20477724.2016.1195036

Cationic Host Defense Peptides (HDP, also known as antimicrobial peptides) are crucial components of the innate immune system and possess broad-spectrum antibacterial, antiviral, and immunomodulatory activities. They can contribute to the rapid clear... Read More about Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections.

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis (2016)
Journal Article
Castillo-Quan, J., Li, L., Kinghorn, K., Ivanov, D., Tain, L., Slack, C., Kerr, F., Nespital, T., Thornton, J., Hardy, J., Bjedov, I., & Partridge, L. (2016). Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis. Cell Reports, 15(3), 638-650. https://doi.org/10.1016/j.celrep.2016.03.041

The quest to extend healthspan via pharmacological means is becoming increasingly urgent, both from a health and economic perspective. Here we show that lithium, a drug approved for human use, promotes longevity and healthspan. We demonstrate that li... Read More about Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis.

BioGRID: A Resource for Studying Biological Interactions in Yeast: Table 1. (2016)
Journal Article
Oughtred, R., Chatr-aryamontri, A., Breitkreutz, B.-J., Chang, C. S., Rust, J. M., Theesfeld, C. L., Heinicke, S., Breitkreutz, A., Chen, D., Hirschman, J., Kolas, N., Livstone, M. S., Nixon, J., O’Donnell, L., Ramage, L., Winter, A., Reguly, T., Sellam, A., Stark, C., Boucher, L., …Tyers, M. (2016). BioGRID: A Resource for Studying Biological Interactions in Yeast: Table 1. Cold Spring Harbor protocols, 2016(1), pdb.top080754. https://doi.org/10.1101/pdb.top080754

The Biological General Repository for Interaction Datasets (BioGRID) is a freely available public database that provides the biological and biomedical research communities with curated protein and genetic interaction data. Structured experimental evi... Read More about BioGRID: A Resource for Studying Biological Interactions in Yeast: Table 1..