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In an ovine model of polycystic ovary syndrome (PCOS) prenatal androgens suppress female fetal renal gluconeogenesis. (2015)
Journal Article
Kanellopoulos-Langevin, C., Connolly, F., Rae, M. T., Späth, K., Boswell, L., McNeilly, A. S., & Duncan, W. C. (2015). In an ovine model of polycystic ovary syndrome (PCOS) prenatal androgens suppress female fetal renal gluconeogenesis. PLOS ONE, 10, Article e0132113. https://doi.org/10.1371/journal.pone.0132113

Increased maternal androgen exposure during pregnancy programmes a polycystic ovary syndrome (PCOS)-like condition, with metabolic dysfunction, in adult female offspring. Other in utero exposures associated with the development of insulin resistance,... Read More about In an ovine model of polycystic ovary syndrome (PCOS) prenatal androgens suppress female fetal renal gluconeogenesis..

Ovulation and Ovarian Cancer (2008)
Book Chapter
Hillier, S. G., Rae, M. T., & Gubbay, O. (2008). Ovulation and Ovarian Cancer. In Hormonal Carcinogenesis V; (171-178). Springer. https://doi.org/10.1007/978-0-387-69080-3_16

Ovarian cancer (OC) most frequently arises from the ovarian surface epithelium (OSE), which comprises a single layer of mesothelial, squamous-to-cuboidal cells covering the entire surface of the ovary (1). This dynamic cellular layer and underlying b... Read More about Ovulation and Ovarian Cancer.

Glucocorticoid receptor-mediated regulation of MMP9 gene expression in human ovarian surface epithelial cells (2008)
Journal Article
Rae, M. T., Price, D., Harlow, C. R., Critchley, H. O. D., & Hillier, S. G. (2009). Glucocorticoid receptor-mediated regulation of MMP9 gene expression in human ovarian surface epithelial cells. Fertility and Sterility, 92(2), 703-708. https://doi.org/10.1016/j.fertnstert.2008.06.040

Objective
To obtain proof-of-concept that locally produced anti-inflammatory steroids suppress ovulation-associated extracellular matrix proteases in human ovarian surface epithelial (OSE) cells.

Design
Primary OSE cell cultures treated with int... Read More about Glucocorticoid receptor-mediated regulation of MMP9 gene expression in human ovarian surface epithelial cells.

cAMP response element-binding (CREB) signalling and ovarian surface epithelial cell survival (2006)
Journal Article
Gubbay, O., Rae, M. T., McNeilly, A. S., Donadeu, F. X., Zeleznik, A. J., & Hillier, S. G. (2006). cAMP response element-binding (CREB) signalling and ovarian surface epithelial cell survival. Journal of Endocrinology, 191(1), 275-285. https://doi.org/10.1677/joe.1.06928

cAMP response-element binding (CREB) transcription factors transduce cell survival responses to peptide hormones and growth factors in normal tissues and mutant CREB proteins are implicated in tumorigenesis. Ovarian cancer most frequently arises from... Read More about cAMP response element-binding (CREB) signalling and ovarian surface epithelial cell survival.

Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas (2005)
Journal Article
Gubbay, O., Guo, W., Rae, M. T., Niven, D., Langdon, S. P., & Hillier, S. G. (2005). Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas. British Journal of Cancer, 92, 1927-1933. https://doi.org/10.1038/sj.bjc.6602568

Ovulation is believed to contribute to the development of ovarian cancers that derive from the ovarian surface epithelium (OSE). The process of ovulation is synonymous with inflammation and inflammatory cytokines such as interleukin-1α (IL-1α) have r... Read More about Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas.

Impact of maternal undernutrition and fetal number on glucocorticoid, growth hormone and insulin-like growth factor receptor mRNA abundance in the ovine fetal kidney (2005)
Journal Article
Brennan, K. A., Gopalakrishnan, G. S., Kurlak, L., Rhind, S. M., Kyle, C. E., Brooks, A. N., Rae, M. T., Olson, D. M., Stephenson, T., & Symonds, M. E. (2005). Impact of maternal undernutrition and fetal number on glucocorticoid, growth hormone and insulin-like growth factor receptor mRNA abundance in the ovine fetal kidney. Reproduction, 129, 151-159. https://doi.org/10.1530/rep.1.00229

Epidemiological and animal studies strongly indicate that the environment experienced in utero determines, in part, an individual’s likelihood of developing cardiovascular disease in later life. This risk has been further linked to impaired kidney fu... Read More about Impact of maternal undernutrition and fetal number on glucocorticoid, growth hormone and insulin-like growth factor receptor mRNA abundance in the ovine fetal kidney.

Anti-inflammatory and proliferative responses in human and ovine ovarian surface epithelial cells (2004)
Journal Article
Gubbay, O., Guo, W., Rae, M. T., Niven, D., Howie, A. F., McNeilly, A. S., Xu, L., & Hillier, S. G. (2004). Anti-inflammatory and proliferative responses in human and ovine ovarian surface epithelial cells. Reproduction, 128, 607-614. https://doi.org/10.1530/rep.1.00272

The majority of ovarian cancers (>90%) are believed to derive from the ovarian surface epithelium (OSE); a single layer covering the entire surface of the ovary. At ovulation, the OSE cell layer undergoes an inflammatory response, involving cell deat... Read More about Anti-inflammatory and proliferative responses in human and ovine ovarian surface epithelial cells.

Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis. (2004)
Journal Article
Rae, M. T., Niven, D., Ross, A., Forster, T., Lathe, R., Critchley, H. O. D., Ghazal, P., & Hillier, S. G. (2004). Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis. Journal of Endocrinology, 183, 19-28. https://doi.org/10.1677/joe.1.05754

The human ovarian surface epithelium (HOSE) is a common site of gynaecological disease including endometriosis and ovarian cancer, probably due to serial injury-repair events associated with successive ovulations. To comprehend the importance of ster... Read More about Steroid signalling in human ovarian surface epithelial cells: the response to interleukin-1alpha determined by microarray analysis..

Programming of adult cardiovascular function after early maternal undernutrition in sheep (2004)
Journal Article
Gopalakrishnan, G. S., Gardner, D. S., Rhind, S. M., Rae, M. T., Kyle, C. E., Brooks, A. N., Walker, R. M., Ramsay, M. M., Keisler, D. H., Stephenson, T., & Symonds, M. E. (2004). Programming of adult cardiovascular function after early maternal undernutrition in sheep. American journal of physiology: regulatory, integrative and comparative physiology, 287(1), R12-R20. https://doi.org/10.1152/ajpregu.00687.2003

The prenatal nutritional environment influences the subsequent risk of hypertension in adulthood. Animal studies have used, generally, the rat as a model species to illustrate the association between maternal nutrient intake and blood pressure in the... Read More about Programming of adult cardiovascular function after early maternal undernutrition in sheep.

Protein kinase C- and Ca2+ ionophore-stimulated production of reactive oxygen species in mechanically dispersed isolated bovine luteal cells (1997)
Journal Article
Sakka, E., Rae, M., Bramley, T., & Aitken, J. (1997). Protein kinase C- and Ca2+ ionophore-stimulated production of reactive oxygen species in mechanically dispersed isolated bovine luteal cells. Biology of Reproduction, 57(2), 428-435

We measured the production of reactive oxygen species (ROS) using luminol-horseradish peroxidase-induced chemiluminescence in mechanically dispersed cell suspensions from bovine corpus luteum (CL). Since other cell types besides luteal cells were pre... Read More about Protein kinase C- and Ca2+ ionophore-stimulated production of reactive oxygen species in mechanically dispersed isolated bovine luteal cells.