Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction (2014)
Journal Article
Wilmot, E. G., Leggate, M., Khan, J. N., Yates, T., Gorely, T., Bodicoat, D. H., Khunti, K., Kuijer, J. P. A., Gray, L. J., Singh, A., Clarysse, P., Croisille, P., Nimmo, M. A., McCann, G. P., & Davies, M. J. (2014). Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction. Diabetic medicine : a journal of the British Diabetic Association, 31(7), 794-798. https://doi.org/10.1111/dme.12431

Aim

A pilot study to phenotype young adults (< 40 years) with Type 2 diabetes mellitus.
Methods

Twenty people with Type 2 diabetes (aged 18–40 years), 10 lean and 10 obese control subjects underwent detailed assessment, including tagged cardia... Read More about Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction.

Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men (2012)
Journal Article
Patterson, S. D., Leggate, M., Nimmo, M. A., & Ferguson, R. A. (2013). Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men. European Journal of Applied Physiology, 113(3), 713-719. https://doi.org/10.1007/s00421-012-2479-5

It has been suggested that circulating hormones and cytokines are important in the adaptive response to low-load resistance training (LLRT) with blood flow restriction (BFR); however, their response following this type of training in older men is unc... Read More about Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men.

Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males (2012)
Journal Article
Leggate, M., Carter, W. G., Evans, M. J. C., Vennard, R. A., Sribala-Sundaram, S., & Nimmo, M. A. (2012). Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males. Journal of Applied Physiology, 112(8), 1353-1360. https://doi.org/10.1152/japplphysiol.01080.2011

This study aimed to determine whether 2 wk of high-intensity intermittent training (HIIT) altered inflammatory status in plasma and adipose tissue in overweight and obese males. Twelve participants [mean (SD): age 23.7 (5.2) yr, body mass 91.0 (8.0)... Read More about Determination of inflammatory and prominent proteomic changes in plasma and adipose tissue after high-intensity intermittent training in overweight and obese males.

The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling (2010)
Journal Article
Leggate, M., Nowell, M. A., Jones, S. A., & Nimmo, M. A. (2010). The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling. Cell Stress and Chaperones, 15(6), 827-833. https://doi.org/10.1007/s12192-010-0192-z

As interleukin-6 (IL-6), its soluble receptor (sIL-6R), and the IL-6/sIL-6R complex is transiently elevated in response to prolonged moderate-intensity exercise, this study investigated how these levels would be modulated by an acute bout of high-int... Read More about The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling.

Individual responsiveness to exercise-induced fat loss is associated with change in resting substrate utilization (2009)
Journal Article
Barwell, N. D., Malkova, D., Leggate, M., & Gill, J. M. R. (2009). Individual responsiveness to exercise-induced fat loss is associated with change in resting substrate utilization. Metabolism, 58(9), 1320-1328. https://doi.org/10.1016/j.metabol.2009.04.016

Fat loss in response to exercise training varies between individuals, even when differences in compliance to the exercise program are accounted for. The purpose of this study was to investigate whether individual variation in change in fasting respir... Read More about Individual responsiveness to exercise-induced fat loss is associated with change in resting substrate utilization.