The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling

Leggate, Melanie; Nowell, Mari A; Jones, Simon A; Nimmo, Myra A

Abstract

As interleukin-6 (IL-6), its soluble receptor (sIL-6R), and the IL-6/sIL-6R complex is transiently elevated in response to prolonged moderate-intensity exercise, this study investigated how these levels would be modulated by an acute bout of high-intensity intermittent (HIIT) exercise in comparison to continuous moderate-intensity exercise (MOD). This study also investigated the expression of the differentially spliced sIL-6R (DS-sIL-6R) in response to exercise. Eleven healthy males completed two exercise trials matched for external work done (582 ± 82 kJ). During MOD, participants cycled at 61.8 (2.6)% VO2peak for 58.7 (1.9) min, while HIIT consisted of ten 4-min intervals cycling at 87.5 (3.4)% TeX separated by 2-min rest. Blood samples were collected pre-exercise, post-exercise, and 1.5, 6, and 23 h post-exercise. Plasma IL-6, sIL-6R, IL-6/sIL-6R complex, and DS-sIL-6R levels were measured by enzyme-linked immunosorbent assay. HIIT caused a significantly greater increase in IL-6 than MOD (P = 0.018). Both MOD and HIIT resulted in an increase in sIL-6R and IL-6/sIL-6R complex (P 

Citation

Leggate, M., Nowell, M. A., Jones, S. A., & Nimmo, M. A. (2010). The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling. Cell Stress and Chaperones, 15, 827-833. https://doi.org/10.1007/s12192-010-0192-z

• Journal Article Type: Article
• Publication Date: 2010
• Deposit Date: Mar 27, 2014
• Print ISSN: 1355-8145
• Electronic ISSN: 1466-1268
• Publisher: BMC
• Peer Reviewed: Peer Reviewed
• Volume: 15
• Pages: 827-833
• DOI: https://doi.org/10.1007/s12192-010-0192-z
• Keywords: Intermittent exercise; IL-6R differential splicing
• Public URL: http://researchrepository.napier.ac.uk/id/eprint/6679
• Publisher URL: http://dx.doi.org/10.1007/s12192-010-0192-z