Problems and solutions: Accounts by parents and children of adhering to chest physiotherapy for cystic fibrosis (2007)
Journal Article
Williams, B., Mukhopadhyay, S., Dowell, J., & Coyle, J. (2007). Problems and solutions: Accounts by parents and children of adhering to chest physiotherapy for cystic fibrosis. Disability and Rehabilitation, 29(14), 1097-1105

Although chest physiotherapy is central to the management of cystic fibrosis (CF), adherence among children is problematic. This study explores accounts by parents and children of the difficulties of adhering to chest physiotherapy for cystic fibrosi... Read More about Problems and solutions: Accounts by parents and children of adhering to chest physiotherapy for cystic fibrosis.

P214 NMDA receptor signalling in human osteoarthritic chondrocytes. (2007)
Presentation / Conference Contribution
Ramage, L., Hardingham, G., & Salter, D. (2007, September). P214 NMDA receptor signalling in human osteoarthritic chondrocytes. Presented at ICRS 2007, Warsaw, Poland

Purpose: Human OA chondrocytes are known to express several subunits of the NMDA receptor (NMDAR), a neuronal signalling molecule. This study analyses downstream activation events and interactions of NMDAR with molecules known to be involved in chond... Read More about P214 NMDA receptor signalling in human osteoarthritic chondrocytes..

The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle (2007)
Journal Article
Qiu, G.-H., Salto-Tellez, M., Ross, J. A., Yeo, W., Cui, Y., Wheelhouse, N., Chen, G. G., Harrison, D., Lai, P., Tao, Q., & Hooi, S. C. (2008). The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle. Journal of Hepatology, 48(3), 433-441. https://doi.org/10.1016/j.jhep.2007.11.015

Background/Aims: The chromosome locus 3p21.3 is a ‘‘hot-spot” for chromosomal aberrations and loss of heterozygosity in cancers. The 35 genes mapped to the AP20 subregion of this locus were screened for their expression to identify candidate tumor su... Read More about The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle.

Working with Older People with Cancer: Challenges in Research and Clinical Practice. (2007)
Book Chapter
Chouliara, Z., & Kearney, N. (2007). Working with Older People with Cancer: Challenges in Research and Clinical Practice. In F. Anagnostopoulos, & E. Karadimas (Eds.), Special Issues in Health Psychology (131-151). Livani Publishers

Expression of Cannabinoid CB1 receptors in models of diabetic neuropathy (2007)
Journal Article
Zhang, F., Hong, S., Stone, V., & Smith, P. (2007). Expression of Cannabinoid CB1 receptors in models of diabetic neuropathy. Journal of Pharmacology and Experimental Therapeutics, 323, 508-515. https://doi.org/10.1124/jpet.107.128272

A clearer understanding of the mechanisms underlying the development and progression of diabetic neuropathy is likely to indicate new directions for the treatment of this complication of diabetes. In the present study we investigated the expression o... Read More about Expression of Cannabinoid CB1 receptors in models of diabetic neuropathy.

α4β2-Nicotinic Receptor Binding with 5-IA in Alzheimer’s Disease: Methods of Scan Analysis (2007)
Journal Article
Terrière, E., Sharman, M., Donaghey, C., Herrmann, L., Lonie, J., Strachan, M., Dougall, N., Best, J., Ebmeier, K. P., Pimlott, S., Patterson, J., & Wyper, D. (2008). α4β2-Nicotinic Receptor Binding with 5-IA in Alzheimer’s Disease: Methods of Scan Analysis. Neurochemical research, 33(4), 643-651. https://doi.org/10.1007/s11064-007-9517-4

Five patients with Alzheimer's disease and five healthy volunteers were examined by SPECT with the nicotinic receptor ligand 123I-5-IA-85380. Patients were scanned before and after 6 weeks of treatment with donepezil. Quantification by regions of int... Read More about α4β2-Nicotinic Receptor Binding with 5-IA in Alzheimer’s Disease: Methods of Scan Analysis.

Promoting the use of Personal Asthma Action Plans: a systematic review (2007)
Journal Article
Ring, N., Malcolm, C., Wyke, S., MacGillivray, S., Dixon, D., Hoskins, G., Pinnock, H., & Sheikh, A. (2007). Promoting the use of Personal Asthma Action Plans: a systematic review. Primary Care Respiratory Journal, 16(5), 271-283. https://doi.org/10.3132/pcrj.2007.00049

Objectives: To investigate how best to encourage health professionals to promote, and for people with asthma to use, asthma action plans.
Methods: Systematic review. Randomised controlled trials published between 1960 and 2006 were searched using mu... Read More about Promoting the use of Personal Asthma Action Plans: a systematic review.

The impact of general practitioner morale on patient satisfaction with care: a cross-sectional study (2007)
Journal Article
McKinstry, B., Walker, J., Porter, M., Fulton, C., Tait, A., Hanley, J., & Mercer, S. (2007). The impact of general practitioner morale on patient satisfaction with care: a cross-sectional study. BMC Family Practice, 8(1), https://doi.org/10.1186/1471-2296-8-57

Background
The association between stress and morale among general practitioners (GP) is well documented. However, the impact of GP stress or low morale on patient care is less clear. GPs in the UK now routinely survey patients about the quality of... Read More about The impact of general practitioner morale on patient satisfaction with care: a cross-sectional study.

Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure (2007)
Journal Article
Barlow, P. G., Brown, D. M., Donaldson, K., MacCallum, J., & Stone, V. (2008). Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure. Cell Biology and Toxicology, 24(3), 243-252. https://doi.org/10.1007/s10565-007-9033-y

Increased levels of particulate air pollution (PM10) have been implicated as a causal agent in pulmonary disease exacerbation and increased deaths from respiratory and cardiovascular disorders. The exact mechanism by which PM10 drives toxicity in the... Read More about Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure.

Illness appraisals and self-esteem as correlates of anxiety and affective comorbid disorders in schizophrenia (2007)
Journal Article
Karatzias, T., Gumley, A., Power, K., & O'Grady, M. (2007). Illness appraisals and self-esteem as correlates of anxiety and affective comorbid disorders in schizophrenia. Comprehensive Psychiatry, 48(4), 371-375. https://doi.org/10.1016/j.comppsych.2007.02.005

Comorbidity of anxiety and affective disorders in people with a diagnosis of schizophrenia is common. This study investigated the hypothesis that greater negative beliefs about illness and lower self-esteem will be significantly associated with the p... Read More about Illness appraisals and self-esteem as correlates of anxiety and affective comorbid disorders in schizophrenia.

The frequency and cause of anxiety and depression amongst patients with malignant brain tumours between surgery and radiotherapy (2007)
Journal Article
Kilbride, L., Smith, G., & Grant, R. (2007). The frequency and cause of anxiety and depression amongst patients with malignant brain tumours between surgery and radiotherapy. Journal of Neuro-Oncology, 84(3), 297-304. https://doi.org/10.1007/s11060-007-9374-7

Introduction Between surgery and radiotherapy patients with a malignant glioma may encounter a number of psychosocial issues that could invoke an anxious or depressive response. This study explored the frequency, severity and cause of anxiety and de... Read More about The frequency and cause of anxiety and depression amongst patients with malignant brain tumours between surgery and radiotherapy.

Role of Androgens in Fetal Testis Development and Dysgenesis (2007)
Journal Article
Scott, H. M., Hutchison, G. R., Mahood, I. K., Hallmark, N., Welsh, M., De Gendt, K., Verhoeven, G., O’Shaughnessy, P., & Sharpe, R. M. (2007). Role of Androgens in Fetal Testis Development and Dysgenesis. Endocrinology, 148(5), 2027-2036. https://doi.org/10.1210/en.2006-1622

This study sought to establish whether reduced androgen levels/action in the fetal rat testis induced by di(n-butyl) phthalate (DBP) contributes to dysgenetic features, namely reduced Sertoli cell number, occurrence of multinucleated gonocytes (MNG),... Read More about Role of Androgens in Fetal Testis Development and Dysgenesis.

Randomized Comparison of Dry Dressings Versus Hydrogel in Management of Radiation-Induced Moist Desquamation (2007)
Journal Article
Macmillan, M. S., Wells, M., MacBride, S., Raab, G. M., Munro, A., & MacDougall, H. (2007). Randomized Comparison of Dry Dressings Versus Hydrogel in Management of Radiation-Induced Moist Desquamation. International Journal of Radiation Oncology - Biology - Physics, 68(3), 864-872. https://doi.org/10.1016/j.ijrobp.2006.12.049

Purpose: We present the results of a randomized controlled clinical trial that evaluated the effect of a hydrogel or dry dressing on the time to healing of moist desquamation after radiotherapy to the head-and-neck, breast, or anorectal areas.

Met... Read More about Randomized Comparison of Dry Dressings Versus Hydrogel in Management of Radiation-Induced Moist Desquamation.

Chemical Genetics Approach to Identify Peptide Ligands that Selectively Stimulate DAPK-1 Kinase Activity (2007)
Journal Article
Fraser, J. A., & Hupp, T. R. (2007). Chemical Genetics Approach to Identify Peptide Ligands that Selectively Stimulate DAPK-1 Kinase Activity. Biochemistry, 46(10), 2655-2673. https://doi.org/10.1021/bi061562j

Dissection of signal transduction pathways has been advanced by classic genetic approaches including targeted gene deletion and siRNA-based inhibition of gene product synthesis. Chemical genetics is a biochemical approach to develop small peptide-mim... Read More about Chemical Genetics Approach to Identify Peptide Ligands that Selectively Stimulate DAPK-1 Kinase Activity.

P186 Expression of functional NMDA receptors in human OA chondrocytes (2007)
Presentation / Conference Contribution
Ramage, L., Martel, M.-A., Hardingham, G., & Salter, D. (2006, December). P186 Expression of functional NMDA receptors in human OA chondrocytes. Presented at 2006 World Congress on Osteoarthritis, Prague, Czechia

Purpose: Classical neuronal signalling molecules such as substance P and glutamate have been identified in cartilage and are being shown to have roles in regulation of chondrocyte function. This study looks at the expression and function of the metab... Read More about P186 Expression of functional NMDA receptors in human OA chondrocytes.

Thyroid hormone signaling in human ovarian surface epithelial cells. (2007)
Journal Article
Rae, M. T., Gubbay, O., Kostogiannou, A., Price, D., Critchley, H. O. D., & Hillier, S. G. (2007). Thyroid hormone signaling in human ovarian surface epithelial cells. Journal of Clinical Endocrinology and Metabolism, 92(1), 322-327. https://doi.org/10.1210/jc.2006-1522

Ovarian surface epithelial (OSE) cells express multiple nuclear hormone receptor genes, including those encoding thyroid hormone and estrogen receptors (TR and ER, respectively). Ovarian cancer is hormone-dependent, and epidemiological evidence links... Read More about Thyroid hormone signaling in human ovarian surface epithelial cells..