Current perspectives on the transmission of Q fever: Highlighting the need for a systematic molecular approach for a neglected disease in Africa. (2019)
Journal Article
Salifu, S. P., Bukari, A.-R. A., Frangoulidis, D., & Wheelhouse, N. (2019). Current perspectives on the transmission of Q fever: Highlighting the need for a systematic molecular approach for a neglected disease in Africa. Acta tropica, 193, 99-105. https://doi.org/10.1016/j.actatropica.2019.02.032

Q fever is a bacterial worldwide zoonosis (except New Zealand) caused by the Gram-negative obligate intracellular bacterium Coxiella burnetii (C. burnetii). The bacterium has a large host range including arthropods, wildlife and companion animals and... Read More about Current perspectives on the transmission of Q fever: Highlighting the need for a systematic molecular approach for a neglected disease in Africa..

Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction (2019)
Journal Article
Wattegedera, S. R., Doull, L. E., Goncheva, M. I., Wheelhouse, N., Watson, D. M., Pearce, J., Benavides, J., Palarea-Albaladejo, J., Mcinnes, C. J., Ballingall, K., & Entrican, G. (2019). Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction. Frontiers in Immunology, 9, https://doi.org/10.3389/fimmu.2018.03025

Successful mammalian pregnancies are a result of complex physiological, endocrinological and immunological processes that combine to create an environment where the mother is tolerant to the semi-allogeneic fetus. Our knowledge of the mechanisms that... Read More about Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction.

Control of Antimicrobial Resistance Requires an Ethical Approach (2017)
Journal Article
Parsonage, B., Hagglund, P. K., Keogh, L., Wheelhouse, N., Brown, R. E., & Dancer, S. J. (2017). Control of Antimicrobial Resistance Requires an Ethical Approach. Frontiers in Microbiology, 8, https://doi.org/10.3389/fmicb.2017.02124

Ethical behavior encompasses actions that benefit both self and society. This means that tackling antimicrobial resistance (AMR) becomes an ethical obligation, because the prospect of declining anti-infectives affects everyone. Without preventive act... Read More about Control of Antimicrobial Resistance Requires an Ethical Approach.

Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila (2016)
Journal Article
Wheelhouse, N., Flockhart, A., Aitchison, K., Livingstone, M., Finlayson, J., Flachon, V., Sellal, E., Dagleish, M. P., & Longbottom, D. (2016). Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila. Scientific Reports, 6, 37150. https://doi.org/10.1038/srep37150

Waddlia chondrophila is a Gram-negative intracellular bacterial organism that is related to classical chlamydial species and has been implicated as a cause of abortion in cattle. Despite an increasing number of observational studies linking W. chondr... Read More about Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila.

Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep (2013)
Journal Article
Longbottom, D., Livingstone, M., Maley, S., van der Zon, A., Rocchi, M., Wilson, K., Wheelhouse, N., Dagleish, M., Aitchison, K., Wattegedera, S., Nath, M., Entrican, G., & Buxton, D. (2013). Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep. PLOS ONE, 8(2), Article e57950. https://doi.org/10.1371/journal.pone.0057950

BACKGROUND: Latency is a key feature of the animal pathogen Chlamydia abortus, where infection remains inapparent in the non-pregnant animal and only becomes evident during a subsequent pregnancy. Often the first sign that an animal is infected is ab... Read More about Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep.

Proteolysis-inducing factor core peptide mediates dermcidin-induced proliferation of hepatic cells through multiple signalling networks (2011)
Journal Article
Lowrie, A. G., Dickinson, P., Wheelhouse, N., Stewart, G. D., Ross, A. J., Forster, T., & Ross, J. A. (2011). Proteolysis-inducing factor core peptide mediates dermcidin-induced proliferation of hepatic cells through multiple signalling networks. International Journal of Oncology, 39(3), 709-18. https://doi.org/10.3892/ijo.2011.1064

Dermcidin is a candidate oncogene capable of increasing the number of cultured neuronal, breast cancer and prostate cancer cells and improving the survival of hepatic cells. The dermcidin gene encodes the proteolysis-inducing factor core pepti... Read More about Proteolysis-inducing factor core peptide mediates dermcidin-induced proliferation of hepatic cells through multiple signalling networks.

The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle (2007)
Journal Article
Qiu, G.-H., Salto-Tellez, M., Ross, J. A., Yeo, W., Cui, Y., Wheelhouse, N., Chen, G. G., Harrison, D., Lai, P., Tao, Q., & Hooi, S. C. (2008). The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle. Journal of Hepatology, 48(3), 433-441. https://doi.org/10.1016/j.jhep.2007.11.015

Background/Aims: The chromosome locus 3p21.3 is a ‘‘hot-spot” for chromosomal aberrations and loss of heterozygosity in cancers. The 35 genes mapped to the AP20 subregion of this locus were screened for their expression to identify candidate tumor su... Read More about The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle.

Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma (2006)
Journal Article
Qui, G.-H., Xie, H., Wheelhouse, N., Harrison, D., Chen, G. G., Salto-Tellez, M., Lai, P., Ross, J. A., & Hooi, S. C. (2007). Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma. Journal of Hepatology, 46(4), 655-663. https://doi.org/10.1016/j.jhep.2006.11.012

BACKGROUND/AIMS: hDAB2IP is a candidate tumor suppressor gene. We studied the expression of its two variants, hDAB2IPA and hDAB2IPB, in normal tissues, and the expression and methylation status of hDAB2IPA in hepatocellular carcinomas (HCC) and cell... Read More about Differential expression of hDAB2IPA and hDAB2IPB in normal tissues and promoter methylation of hDAB2IPA in hepatocellular carcinoma.

Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver (2005)
Journal Article
Wheelhouse, N. M., Lai, P. B. S., Wigmore, S. J., Ross, J. A., & Harrison, D. J. (2005). Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver. British Journal of Cancer, 92(7), 1268-1272. https://doi.org/10.1038/sj.bjc.6602496

The largest single underlying cause of hepatocellular carcinoma (HCC) worldwide is hepatitis B virus (HBV) infection. Hepatitis B virus increases cellular oxidative stress and the development of HCC occurs after a long latency period. The study was c... Read More about Mitochondrial D-loop mutations and deletion profiles of cancerous and noncancerous liver tissue in hepatitis B virus-infected liver.

Interferon-γ polymorphisms correlate with duration of survival in pancreatic cancer (2004)
Journal Article
Halma, M., Wheelhouse, N., Barber, M., Powell, J., Fearon, K., & Ross, J. (2004). Interferon-γ polymorphisms correlate with duration of survival in pancreatic cancer. Human Immunology, 65(11), 1405-1408. https://doi.org/10.1016/j.humimm.2004.08.184

Despite progress in diagnosis and staging, pancreatic cancer still has a poor prognosis and it remains difficult to predict duration of survival in advanced pancreatic cancer. Nutritional decline, or cachexia, is a contributory factor to decreased su... Read More about Interferon-γ polymorphisms correlate with duration of survival in pancreatic cancer.