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Systematic review and meta-analysis of factors that help or hinder treatment decision-making capacity in psychosis (2017)
Journal Article
Larkin, A., & Hutton, P. (2017). Systematic review and meta-analysis of factors that help or hinder treatment decision-making capacity in psychosis. British Journal of Psychiatry, 211(4), 205-215. https://doi.org/10.1192/bjp.bp.116.193458

Background: The evidence on factors that may influence treatment decisional capacity (‘capacity) in psychosis has yet to be comprehensively synthesised, which limits the development of effective strategies to improve or support it.
Aims: To determin... Read More about Systematic review and meta-analysis of factors that help or hinder treatment decision-making capacity in psychosis.

Quetiapine immediate release v. placebo for schizophrenia: systematic review, meta-analysis and reappraisal (2015)
Journal Article
Hutton, P., Taylor, P. J., Mulligan, L., Tully, S., & Moncrieff, J. (2015). Quetiapine immediate release v. placebo for schizophrenia: systematic review, meta-analysis and reappraisal. British Journal of Psychiatry, 206(5), 360-370. https://doi.org/10.1192/bjp.bp.114.154377

Background:
Immediate-release (IR) quetiapine has been used to treat schizophrenia since 1997, although all the principal placebo-controlled trials have >50% missing outcome data. New studies with relatively lower rates of participant withdrawal hav... Read More about Quetiapine immediate release v. placebo for schizophrenia: systematic review, meta-analysis and reappraisal.

Curiosity and the CAT: Considering Cognitive Analytic Therapy as an intervention for psychosis (2014)
Journal Article
Taylor, P. J., Perry, A., Hutton, P., Seddon, C., & Tan, R. (2015). Curiosity and the CAT: Considering Cognitive Analytic Therapy as an intervention for psychosis. Psychosis, 7(3), 276-278. https://doi.org/10.1080/17522439.2014.956785

In the interests of providing patient choice and developing more effective interventions forvpeople struggling with psychosis, it is important that alternative talking therapies arevexplored. Cognitive Analytic Therapy is an integrative therapy which... Read More about Curiosity and the CAT: Considering Cognitive Analytic Therapy as an intervention for psychosis.

Cognitive therapy for patients with schizophrenia–Authors' reply (2014)
Journal Article
Morrison, A. P., Dunn, G., Turkington, D., Pyle, M., & Hutton, P. (2014). Cognitive therapy for patients with schizophrenia–Authors' reply. Lancet, 384(9941), 401-402. https://doi.org/10.1016/S0140-6736%2814%2961275-7

Our trial1 was not designed to change clinical practice. It was a preliminary trial, which needs to be followed up by a larger, pragmatic multicentre study. It is important not to overinterpret our data, and we explicitly advised against discontinuat... Read More about Cognitive therapy for patients with schizophrenia–Authors' reply.

Rationale and protocol for a systematic review and meta-analysis on reduced data gathering in people with delusions (2014)
Journal Article
Taylor, P., Hutton, P., & Dudley, R. (2014). Rationale and protocol for a systematic review and meta-analysis on reduced data gathering in people with delusions. Systematic Reviews, 3(44), https://doi.org/10.1186/2046-4053-3-44

Background
The tendency to form conclusions based on limited evidence is known as the ‘jumping to conclusions’ (JTC) bias, and has been a much studied phenomena in individuals with psychosis. Previous reviews have supported the hypothesis that a JTC... Read More about Rationale and protocol for a systematic review and meta-analysis on reduced data gathering in people with delusions.

Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs: a single-blind randomised controlled trial (2014)
Journal Article
Morrison, A. P., Turkington, D., Pyle, M., Spencer, H., Brabban, A., Dunn, G., Christodoulides, T., Dudley, R., Chapman, N., Callcott, P., Grace, T., Lumley, V., Drage, L., Tully, S., Irving, K., Cummings, A., Byrne, R., Davies, L. M., & Hutton, P. (2014). Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs: a single-blind randomised controlled trial. Lancet, 383(9926), 1395-1403. https://doi.org/10.1016/s0140-6736%2813%2962246-1

BACKGROUND:
Antipsychotic drugs are usually the first line of treatment for schizophrenia; however, many patients refuse or discontinue their pharmacological treatment. We aimed to establish whether cognitive therapy was effective in reducing psychi... Read More about Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs: a single-blind randomised controlled trial.

Cognitive behavioural therapy for psychosis: rationale and protocol for a systematic review and meta-analysis (2013)
Journal Article
Hutton, P., Wood, L., Taylor, P. J., Irving, K., & Morrison, A. P. (2014). Cognitive behavioural therapy for psychosis: rationale and protocol for a systematic review and meta-analysis. Psychosis, 6(3), 220-230. https://doi.org/10.1080/17522439.2013.825005

Background: Cognitive behavioural therapy (CBT) is a recommended treatment for people with psychosis, with meta - analyses showing important benefits when compared to treatment as usual (TAU). However, there has been growing debate as to whether CBT... Read More about Cognitive behavioural therapy for psychosis: rationale and protocol for a systematic review and meta-analysis.

Antipsychotic Drugs (2013)
Book Chapter
Hutton, P., Weinmann, S., Bola, J., & Read, J. (2013). Antipsychotic Drugs. In Models of Madness: Psychological, Social and Biological Approaches to Psychosis (105-124). (2nd). Routledge

Antipsychotic drugs.

Cognitive-behavioural therapy for schizophrenia: A critical commentary on the Newton-Howes and Wood meta-analysis (2013)
Journal Article
Hutton, P. (2013). Cognitive-behavioural therapy for schizophrenia: A critical commentary on the Newton-Howes and Wood meta-analysis. Psychology and Psychotherapy: Theory, Research and Practice, 86(2), 139-145. https://doi.org/10.1111/papt.12009

Newton-Howes and Wood (published online, this journal, 8 Dec 2011) report the results of their systematic review and meta-analysis of clinical trials of cognitive-behavioural therapy (CBT) for schizophrenia. They ran a random effects analysis of endp... Read More about Cognitive-behavioural therapy for schizophrenia: A critical commentary on the Newton-Howes and Wood meta-analysis.

Cognitive behavioural therapy for psychosis prevention: a systematic review and meta-analysis (2013)
Journal Article
Taylor, P. J., Hutton, P., & Taylor, P. J. (2014). Cognitive behavioural therapy for psychosis prevention: a systematic review and meta-analysis. Psychological Medicine, 44(3), 449-468. https://doi.org/10.1017/s0033291713000354

Background.
Clinical equipoise regarding preventative treatments for psychosis has encouraged the development and evaluation of psychosocial treatments, such as cognitive behavioural therapy (CBT).

Method.
A systematic review and meta-analysis w... Read More about Cognitive behavioural therapy for psychosis prevention: a systematic review and meta-analysis.

Metacognitive therapy in treatment-resistant psychosis: A multiple-baseline study (2013)
Journal Article
Hutton, P., Morrison, A. P., Wardle, M., & Wells, A. (2014). Metacognitive therapy in treatment-resistant psychosis: A multiple-baseline study. Behavioural and Cognitive Psychotherapy, 42(2), 166-185. https://doi.org/10.1017/S1352465812001026

Background:
More effective psychological treatments for psychosis are required. Case series data and pilot trials suggest metacognitive therapy (MCT) is a promising treatment for anxiety and depression. Other research has found negative metacognitiv... Read More about Metacognitive therapy in treatment-resistant psychosis: A multiple-baseline study.

Embracing patient choice - Reply (2012)
Journal Article
Morrison, A. P., Hutton, P., Shiers, D., & Turkington, D. (2012). Embracing patient choice - Reply. British Journal of Psychiatry, 201, 494-495

Reply to the article - "Embracing patient choice" - Lobban, F in The British Journal of Psychiatry Dec 2012, 201 (6) 494; DOI: 10.1192/bjp.201.6.494

Collaborative empiricism in cognitive therapy for psychosis: A practice guide (2012)
Journal Article
Hutton, P., & Morrison, A. P. (2013). Collaborative empiricism in cognitive therapy for psychosis: A practice guide. Cognitive and Behavioral Practice, 20(4), 429-444. https://doi.org/10.1016/j.cbpra.2012.08.003

We outline our understanding of collaborative empiricism (CE) as used in cognitive therapy (CT) for psychosis. We discuss how CE can be thought of as a technique for facilitating cognitive change in the service of a client's goals, but also as an exp... Read More about Collaborative empiricism in cognitive therapy for psychosis: A practice guide.

Self-attacking and self-reassurance in persecutory delusions: A comparison of healthy, depressed and paranoid individuals (2012)
Journal Article
Hutton, P., Kelly, J., Lowens, I., Taylor, P. J., & Tai, S. (2013). Self-attacking and self-reassurance in persecutory delusions: A comparison of healthy, depressed and paranoid individuals. Psychiatry Research, 205(1), 127-136. https://doi.org/10.1016/j.psychres.2012.08.010

Previous research has found that reduced self-reassurance and heightened verbal 'self-attacking' of a sadistic and persecutory nature are both associated with greater subclinical paranoia. Whether these processes are also linked to clinical paranoia... Read More about Self-attacking and self-reassurance in persecutory delusions: A comparison of healthy, depressed and paranoid individuals.

Antipsychotics: is it time to introduce patient choice? (2012)
Journal Article
Morrison, A. P., Hutton, P., Shiers, D., & Turkington, D. (2012). Antipsychotics: is it time to introduce patient choice?. British Journal of Psychiatry, 201(2), 83-84. https://doi.org/10.1192/bjp.bp.112.112110

Evidence regarding overestimation of the efficacy of antipsychotics and underestimation of their toxicity, as well as emerging data regarding alternative treatment options, suggests it may be time to introduce patient choice and reconsider whether ev... Read More about Antipsychotics: is it time to introduce patient choice?.

Effects of drop-out on efficacy estimates in five Cochrane reviews of popular antipsychotics for schizophrenia: Drop-out in Cochrane reviews of antipsychotics (2012)
Journal Article
Hutton, P., Morrison, A. P., Yung, A. R., Taylor, P. J., French, P., & Dunn, G. (2012). Effects of drop-out on efficacy estimates in five Cochrane reviews of popular antipsychotics for schizophrenia: Drop-out in Cochrane reviews of antipsychotics. Acta Psychiatrica Scandinavica, 126(1), 1-11. https://doi.org/10.1111/j.1600-0447.2012.01858.x

Objective:
Our aim was to find out how Cochrane reviews of five popular or frequently prescribed second-generation antipsychotics in the UK (olanzapine, risperidone, quetiapine, amisulpride and aripiprazole) approached the problem of high drop-out i... Read More about Effects of drop-out on efficacy estimates in five Cochrane reviews of popular antipsychotics for schizophrenia: Drop-out in Cochrane reviews of antipsychotics.

A preliminary exploration of predictors of outcome and cognitive mechanisms of change in cognitive behaviour therapy for psychosis in people not taking antipsychotic medication (2011)
Journal Article
Morrison, A. P., Turkington, D., Wardle, M., Spencer, H., Barratt, S., Dudley, R., Brabban, A., & Hutton, P. (2012). A preliminary exploration of predictors of outcome and cognitive mechanisms of change in cognitive behaviour therapy for psychosis in people not taking antipsychotic medication. Behaviour Research and Therapy, 50(2), 163-167. https://doi.org/10.1016/j.brat.2011.12.001

BACKGROUND:

Cognitive behaviour therapy (CBT) has been shown to be effective in an open trial for people with psychotic disorders who have not been taking antipsychotic medication. There is little known about predictors of outcome in CBT for psych... Read More about A preliminary exploration of predictors of outcome and cognitive mechanisms of change in cognitive behaviour therapy for psychosis in people not taking antipsychotic medication.

Prevalence of violence risk factors in people at ultra-high risk of developing psychosis: a service audit: Audit of violence risk in a UHR group (2011)
Journal Article
Hutton, P., Parker, S., Bowe, S., & Ford, S. (2012). Prevalence of violence risk factors in people at ultra-high risk of developing psychosis: a service audit: Audit of violence risk in a UHR group. Early Intervention in Psychiatry, 6(1), 91-96. https://doi.org/10.1111/j.1751-7893.2011.00307.x

Background: There is little data available on the prevalence of violence risk factors in people at ultra-high risk of developing psychosis.

Aim: The aim of this study was to provide an estimate of the cross-sectional prevalence of violence risk fa... Read More about Prevalence of violence risk factors in people at ultra-high risk of developing psychosis: a service audit: Audit of violence risk in a UHR group.