Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation (2007)
Journal Article
Wilson, M. R., Foucaud, L., Barlow, P. G., Hutchison, G. R., Sales, J., Simpson, R. J., & Stone, V. (2007). Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation. Toxicology and Applied Pharmacology, 225(1), 80-89. https://doi.org/10.1016/j.taap.2007.07.012

Particulate air pollution (PM10) consists of a mixture of components, including nanoparticles and metals. Studies from our laboratory have demonstrated that transition metals can potentiate the ability of nanoparticles to induce lung inflammation and... Read More about Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation.

Role of Androgens in Fetal Testis Development and Dysgenesis (2007)
Journal Article
Scott, H. M., Hutchison, G. R., Mahood, I. K., Hallmark, N., Welsh, M., De Gendt, K., Verhoeven, G., O’Shaughnessy, P., & Sharpe, R. M. (2007). Role of Androgens in Fetal Testis Development and Dysgenesis. Endocrinology, 148(5), 2027-2036. https://doi.org/10.1210/en.2006-1622

This study sought to establish whether reduced androgen levels/action in the fetal rat testis induced by di(n-butyl) phthalate (DBP) contributes to dysgenetic features, namely reduced Sertoli cell number, occurrence of multinucleated gonocytes (MNG),... Read More about Role of Androgens in Fetal Testis Development and Dysgenesis.

Anaerobic biodegradation of linear alkylbenzene: isomeric ratio as a monitoring tool (2007)
Journal Article
Johnson, S. J., Barry, D., & Christofi, N. (2007). Anaerobic biodegradation of linear alkylbenzene: isomeric ratio as a monitoring tool. Land Contamination and Reclamation, 15(2), 235-241. https://doi.org/10.2462/09670513.858

Linear alkylbenzenes (LABs) are common environmental contaminants associated with a range of industrial and domestic activities. Although natural environments receiving LABs may exhibit a range of redox conditions, until now only aerobic biodegradati... Read More about Anaerobic biodegradation of linear alkylbenzene: isomeric ratio as a monitoring tool.

Thyroid hormone signaling in human ovarian surface epithelial cells. (2007)
Journal Article
Rae, M. T., Gubbay, O., Kostogiannou, A., Price, D., Critchley, H. O. D., & Hillier, S. G. (2007). Thyroid hormone signaling in human ovarian surface epithelial cells. Journal of Clinical Endocrinology and Metabolism, 92(1), 322-327. https://doi.org/10.1210/jc.2006-1522

Ovarian surface epithelial (OSE) cells express multiple nuclear hormone receptor genes, including those encoding thyroid hormone and estrogen receptors (TR and ER, respectively). Ovarian cancer is hormone-dependent, and epidemiological evidence links... Read More about Thyroid hormone signaling in human ovarian surface epithelial cells..

The efficacy of certain anti-tuberculosis drugs is affected by binding to alpha-1-acid glycoprotein. (2006)
Journal Article
Johnson, D. A., & Smith, K. (2006). The efficacy of certain anti-tuberculosis drugs is affected by binding to alpha-1-acid glycoprotein. Biomedical Chromatography, 20, 551-560. https://doi.org/10.1002/bmc.641

One of the most ubiquitous plasma proteins, -1-acid glycoprotein (AGP), has a high affinity, low capacity binding for basic drugs positively charged at physiological pH. Moreover, as an acute phase protein its level is increased in various disease st... Read More about The efficacy of certain anti-tuberculosis drugs is affected by binding to alpha-1-acid glycoprotein..

Anthracene derivatives as anti-cancer agents. (2004)
Patent
Mincher, D., & Turnbull, A. (2004). Anthracene derivatives as anti-cancer agents

The present invention relates to compounds which are based on an anthraquinone nucleus for use in medicine, particularly as anti-cancer agents which exert their effects through their interaction with the activity of topoisomerases. The inhibition of... Read More about Anthracene derivatives as anti-cancer agents..

Stereospecific synthesis of chiral caprolactone monomers from D-glucose. (2003)
Journal Article
Defossemont, G., & Mincher, D. (2003). Stereospecific synthesis of chiral caprolactone monomers from D-glucose. Carbohydrate Research, 338(6), 563-565. https://doi.org/10.1016/S0008-6215%2802%2900490-1

The synthesis and characterisation of a novel chiral bicyclic oxacaprolactone is reported. The choice of diisopropylidene- -glucose as a starting material allowed selective introduction of the synthetic equivalent necessary for the formation of the s... Read More about Stereospecific synthesis of chiral caprolactone monomers from D-glucose..

The ‘Chicken and Egg’ Problem of Co-evolution of Peptides and Their Cognate Receptors: Which Came First? (1999)
Book Chapter
Darlison, M. G., & Richter, D. (1999). The ‘Chicken and Egg’ Problem of Co-evolution of Peptides and Their Cognate Receptors: Which Came First?. In D. Richter (Ed.), Regulatory Peptides and Cognate Receptors (1-11). Springer. https://doi.org/10.1007/978-3-540-49421-8_1

As will be evident from the other chapters in this Volume, small peptide molecules regulate a wide variety of biological processes in both vertebrate and invertebrate species. For each bioactive peptide there exists one or more specific membrane-boun... Read More about The ‘Chicken and Egg’ Problem of Co-evolution of Peptides and Their Cognate Receptors: Which Came First?.