Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep (2013)
Journal Article
Longbottom, D., Livingstone, M., Maley, S., van der Zon, A., Rocchi, M., Wilson, K., Wheelhouse, N., Dagleish, M., Aitchison, K., Wattegedera, S., Nath, M., Entrican, G., & Buxton, D. (2013). Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep. PLOS ONE, 8(2), Article e57950. https://doi.org/10.1371/journal.pone.0057950

BACKGROUND: Latency is a key feature of the animal pathogen Chlamydia abortus, where infection remains inapparent in the non-pregnant animal and only becomes evident during a subsequent pregnancy. Often the first sign that an animal is infected is ab... Read More about Intranasal infection with Chlamydia abortus induces dose-dependent latency and abortion in sheep.

Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo (2013)
Journal Article
Xue, S.-A., Gao, L., Ahmadi, M., Ghorashian, S., Barros, R. D., Pospori, C., Holler, A., Wright, G., Thomas, S., Topp, M., Morris, E. C., & Stauss, H. J. (2013). Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo. OncoImmunology, 2(1), Article e22590. https://doi.org/10.4161/onci.22590

In this study, we generated human MHC Class I-restricted CD4+ T cells specific for Epstein-Barr virus (EBV) and cytomegalovirus (CMV), two herpesviridae associated with lymphoma, nasopharyngeal carcinoma and medulloblastoma, respectively. Retroviral... Read More about Human MHC Class I-restricted high avidity CD4 + T cells generated by co-transfer of TCR and CD8 mediate efficient tumor rejection in vivo.

Therapeutic potential of Tregs to treat rheumatoid arthritis (2011)
Journal Article
Wright, G. P., Stauss, H. J., & Ehrenstein, M. R. (2011). Therapeutic potential of Tregs to treat rheumatoid arthritis. Seminars in Immunology, 23(3), 195-201. https://doi.org/10.1016/j.smim.2011.07.004

There is accumulating evidence for regulatory T cell defects in rheumatoid arthritis and that some biologic interventions, in particular anti-TNF, can target this population. Despite the challenges in defining regulatory T cells in patients, there ar... Read More about Therapeutic potential of Tregs to treat rheumatoid arthritis.

Molecular detection of Chlamydia-like organisms in cattle drinking water (2011)
Journal Article
Wheelhouse, N., Saita, M., Gidlow, J., Deuchande, R., Borel, N., Baily, J., Caldow, G., & Longbottom, D. (2011). Molecular detection of Chlamydia-like organisms in cattle drinking water. Veterinary Microbiology, 152(1-2), 196-199. https://doi.org/10.1016/j.vetmic.2011.03.040

A substantial proportion of the causes of infectious bovine abortion remain largely undiagnosed, potentially due to the presence of previously unrecognised infectious agents. Recently, several reports have demonstrated the presence of Parachlamydia s... Read More about Molecular detection of Chlamydia-like organisms in cattle drinking water.

Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells (2011)
Journal Article
Notley, C. A., Brown, M. A., Wright, G. P., & Ehrenstein, M. R. (2011). Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells. The journal of immunology : official journal of the American Association of Immunologists, 186(8), 4967-4972. https://doi.org/10.4049/jimmunol.1003021

The clearance of dying cells is vital for re-establishing tolerance during inflammation and has potent immunoregulatory consequences. Because natural IgM plays a key role in the removal of apoptotic cells, we investigated whether the immune modulator... Read More about Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells.

Immunomodulatory effects of cannabinoids in human T-lymphocytes (2009)
Presentation / Conference Contribution
Schinwald, A., Galban-Horcajo, F., Malone, E., & Smith, P. (2009, December). Immunomodulatory effects of cannabinoids in human T-lymphocytes. Presented at British Pharmacology Society Winter Meeting 2009

Background: Circulating levels of endocannabinoids are elevated in obese and hyperglycaemic patients and may contribute to immune dysfunction in obesity and diabetes. Cannabinoids have been shown to evoke both pro-and anti-inflammatory responses, act... Read More about Immunomodulatory effects of cannabinoids in human T-lymphocytes.

Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction (2009)
Journal Article
Lin, Y., Hupp, T. R., & Stevens, C. (2010). Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction. FEBS Journal, 277(1), 48-57. https://doi.org/10.1111/j.1742-4658.2009.07411.x

Death-associated protein kinase (DAPK) is a stress-regulated protein
kinase that mediates a range of processes, including signal-induced cell death and autophagy. Although the kinase domain of DAPK has a range of substrates that mediate its signalli... Read More about Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction.

Autophagy: from basic science to clinical application (2009)
Journal Article
Van Limbergen, J., Stevens, C., Nimmo, E. R., Wilson, D. C., & Satsangi, J. (2009). Autophagy: from basic science to clinical application. Mucosal immunology, 2(4), 315-330. https://doi.org/10.1038/mi.2009.20

Autophagy is a cellular pathway involved in protein and organelle degradation, which is likely to represent an innate adaptation to starvation. In times of nutrient deficiency, the cell can self-digest and recycle some nonessential components through... Read More about Autophagy: from basic science to clinical application.

NuMA is required for proper spindle assembly and chromosome alignment in prometaphase (2009)
Journal Article
Haren, L., Gnadt, N., Wright, M., & Merdes, A. (2009). NuMA is required for proper spindle assembly and chromosome alignment in prometaphase. BMC Research Notes, 2, Article 64. https://doi.org/10.1186/1756-0500-2-64

NuMA is a protein that has been previously shown to play a role in focusing microtubules at the mitotic spindle poles. However, most previous work relies on experimental methods that might cause dominant side effects on spindle formation, such as mic... Read More about NuMA is required for proper spindle assembly and chromosome alignment in prometaphase.

Effect of Nippostrongylus brasiliensis L3 ES on inflammatory mediator gene transcription in lipopolysaccharide lung inflammation (2008)
Journal Article
Zhao, M., Brown, D. M., MacCallum, J., & Proudfoot, L. (2008). Effect of Nippostrongylus brasiliensis L3 ES on inflammatory mediator gene transcription in lipopolysaccharide lung inflammation. Parasite Immunology, 31(1), 50-56. https://doi.org/10.1111/j.1365-3024.2008.01073.x

The anti-inflammatory properties of parasitic helminths have been largely linked to their excretory-secretory (ES) products. Some studies have noted a lack of TNF-alpha production and limited recruitment of neutrophils into the lungs after Nippostron... Read More about Effect of Nippostrongylus brasiliensis L3 ES on inflammatory mediator gene transcription in lipopolysaccharide lung inflammation.

Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise (2008)
Journal Article
Simpson, R. J., Cosgrove, C., Ingram, L. A., Florida-James, G. D., Whyte, G. P., Pircher, H., & Guy, K. (2008). Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise. Brain, Behavior, and Immunity, 22(4), 544-551. https://doi.org/10.1016/j.bbi.2007.11.002

Senescent T-lymphocytes are antigen-experienced cells that express the killer-cell lectin-like receptor G1 (KLRG1) and/or CD57; fail to clonally expand following further antigenic stimulation and prevail in the resting blood of older adults compared... Read More about Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise.

High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects (2007)
Journal Article
Simpson, R. J., Florida-James, G. D., Cosgrove, C., Whyte, G. P., Macrae, S., Pircher, H., & Guy, K. (2007). High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects. Journal of Applied Physiology, 103(1), 396-401. https://doi.org/10.1152/japplphysiol.00007.2007

Clonal expansion of T lymphocytes in response to antigenic stimulation is a fundamental process of adaptive immunity. As a consequence of clonal expansion, some T lymphocytes acquire a senescent phenotype, fail to replicate in response to further ant... Read More about High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects.

Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo. (2005)
Journal Article
Taylor, M. D., LeGoff, L., Harris, A., Malone, E. M., Allen, J. E., & Maizels, R. M. (2005). Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo. Journal of Immunology, 174, 4924-4933

Human filarial parasites cause chronic infection associated with long-term down-regulation of the host’s immune response. We show here that CD4+ T cell regulation is the main determinant of parasite survival. In a laboratory model of infection, using... Read More about Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo..

Parasitic helminths tip the balance: potential anti-inflammatory therapies (2004)
Journal Article
Proudfoot, L. (2004). Parasitic helminths tip the balance: potential anti-inflammatory therapies. Immunology, 113(4), 438-440. https://doi.org/10.1111/j.1365-2567.2004.01996.x

Parasitic helminths are worms that are classified within the phyla Nematoda (roundworms) and Platyhelminthes (flatworms) (see Table 1). Some nematode species, Filariae being a notable example, are able to coexist with their human host for decades. In... Read More about Parasitic helminths tip the balance: potential anti-inflammatory therapies.

Apoptosis induced by Paclitaxel, tobacco smoke condensate and hydrogen peroxide in lung epithelial cells (A549) (2004)
Presentation / Conference Contribution
Ramage, L., Jones, A., & Whelan, C. Apoptosis induced by Paclitaxel, tobacco smoke condensate and hydrogen peroxide in lung epithelial cells (A549)

Cigarette smoke is known to be a complex mixture of >4000 constituents dispersed between the volatile and non-volatile phase, and inhaled exposure causes lung inflammation and cell injury. Here we investigate the effects of some of components of ciga... Read More about Apoptosis induced by Paclitaxel, tobacco smoke condensate and hydrogen peroxide in lung epithelial cells (A549).

Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles (2004)
Journal Article
Brown, D. M., Donaldson, K., Borm, P. J., Schins, R. P., Dehnhardt, M., Gilmour, P., Jimenez, L. A., & Stone, V. (2004). Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles. American Journal of Physiology - Lung Cellular and Molecular Physiology, 286(2), L344-L353. https://doi.org/10.1152/ajplung.00139.2003

Ultrafine (Uf) particles are a component of particulate air pollution suggested to be responsible for the health effects associated with elevations of this pollutant. We have previously suggested that Uf particles, through the induction of oxidative... Read More about Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles.

A role for immunology in 'next generation' robots. (2003)
Presentation / Conference Contribution
Hart, E., Ross, P., Webb, A., & Lawson, A. (2003, September). A role for immunology in 'next generation' robots. Presented at Second International Conference, ICARIS 2003, Edinburgh, UK, September 1-3, 2003, Proceedings: volume 2787 of Lecture Notes on Computer Science: Artificial Immune Systems, Editors: Timmis, J., Bentley, P. and Hart, E., Springer, ISBN: 978-3-540-40766-9

Much of current robot research is about learning tasks in which the task to be achieved is pre-specified, a suitable technology for the task is chosen and the learning process is experimentally investigated. A more interesting research question is ho... Read More about A role for immunology in 'next generation' robots..

1110 Older people with cancer: issues in clinical practice and research (2003)
Journal Article
Kearney, N., Chouliara, Z., Miller, M., & Molassiotis, A. (2003). 1110 Older people with cancer: issues in clinical practice and research. EJC Supplements, 1(5), S334. https://doi.org/10.1016/S1359-6349%2803%2991136-0

ECCO 12 Abstract Book

Aluminium Lactate Treatment of DQ12 Quartz Inhibits Its Ability to Cause Inflammation, Chemokine Expression, and Nuclear Factor-κB Activation (2001)
Journal Article
Duffin, R., Gilmour, P. S., Schins, R. P., Clouter, A., Guy, K., Brown, D. M., MacNee, W., Borm, P. J., Donaldson, K., & Stone, V. (2001). Aluminium Lactate Treatment of DQ12 Quartz Inhibits Its Ability to Cause Inflammation, Chemokine Expression, and Nuclear Factor-κB Activation. Toxicology and Applied Pharmacology, 176(1), 10-17. https://doi.org/10.1006/taap.2001.9268

In 1997, an IARC Working Group classified quartz (crystalline silica) as a Group 1 lung carcinogen, but only in some industries, i.e., the quartz hazard is a variable entity. The reactivity of the quartz surface may underlie its ability to cause infl... Read More about Aluminium Lactate Treatment of DQ12 Quartz Inhibits Its Ability to Cause Inflammation, Chemokine Expression, and Nuclear Factor-κB Activation.