NuMA is required for proper spindle assembly and chromosome alignment in prometaphase

Haren, Laurence; Gnadt, Nicole; Wright, Michel; Merdes, Andreas

Abstract

NuMA is a protein that has been previously shown to play a role in focusing microtubules at the mitotic spindle poles. However, most previous work relies on experimental methods that might cause dominant side effects on spindle formation, such as microinjection of antibodies, overexpression of mutant protein, or immunodepletion of NuMA-containing protein complexes.

Citation

Haren, L., Gnadt, N., Wright, M., & Merdes, A. (2009). NuMA is required for proper spindle assembly and chromosome alignment in prometaphase. BMC Research Notes, 2, Article 64. https://doi.org/10.1186/1756-0500-2-64

• Journal Article Type: Article
• Acceptance Date: Apr 28, 2009
• Publication Date: Apr 28, 2009
• Deposit Date: Jul 27, 2016
• Journal: BMC Research Notes
• Publisher: BMC
• Peer Reviewed: Peer Reviewed
• Volume: 2
• Article Number: 64
• DOI: https://doi.org/10.1186/1756-0500-2-64
• Keywords: NuMA, microtubules, mitotic spindle poles, immunodepletion,
• Public URL: http://researchrepository.napier.ac.uk/Output/318053
• Publisher URL: http://dx.doi.org/10.1186/1756-0500-2-64