Therapeutic potential of Tregs to treat rheumatoid arthritis

Wright, Graham P; Stauss, Hans J; Ehrenstein, Michael R

Abstract

There is accumulating evidence for regulatory T cell defects in rheumatoid arthritis and that some biologic interventions, in particular anti-TNF, can target this population. Despite the challenges in defining regulatory T cells in patients, there are a number of approaches currently being developed to utilise their potent immunosuppressive properties. Through genetic manipulation Tregs can be generated ex vivo or in vivo that target antigens present in the inflamed joint. Here we discuss these approaches, their refinement to restore tolerance in patients with rheumatoid arthritis, and strategies to prevent their conversion towards a Th17 phenotype.

Citation

Wright, G. P., Stauss, H. J., & Ehrenstein, M. R. (2011). Therapeutic potential of Tregs to treat rheumatoid arthritis. Seminars in Immunology, 23(3), 195-201. https://doi.org/10.1016/j.smim.2011.07.004

• Journal Article Type: Article
• Online Publication Date: Aug 30, 2011
• Publication Date: 2011-06
• Deposit Date: Aug 1, 2016
• Journal: Seminars in Immunology
• Print ISSN: 1044-5323
• Electronic ISSN: 1096-3618
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 23
• Issue: 3
• Pages: 195-201
• DOI: https://doi.org/10.1016/j.smim.2011.07.004
• Keywords: rheumatoid arthritis, T cells, Tregs, Th17 phenotype
• Public URL: http://researchrepository.napier.ac.uk/Output/320506