Immunomodulatory effects of cannabinoids in human T-lymphocytes

Schinwald, Anja; Galban-Horcajo, Francesc; Malone, Eva; Smith, Paula

Abstract

Background: Circulating levels of endocannabinoids are elevated in obese and hyperglycaemic patients and may contribute to immune dysfunction in obesity and diabetes. Cannabinoids have been shown to evoke both pro-and anti-inflammatory responses, acting via CB 1 and CB 2 receptors on immune cells. In the present study we compared the responses of human T-cells to varying concentrations (0.1–1000nM) of endocannabinoids (anandamide and 2-arachidonoylglycerol, 2-AG), a phytocannabinoid (Δ 9-tetrahydrocannabinol, Δ 9-THC), and a synthetic CB 2 receptor agonist (JWH-015).

Citation

Schinwald, A., Galban-Horcajo, F., Malone, E., & Smith, P. (2009). Immunomodulatory effects of cannabinoids in human T-lymphocytes. In Proceedings of the British Pharmacological Society

• Conference Name: British Pharmacology Society Winter Meeting 2009
• Start Date: Dec 15, 2009
• End Date: Dec 17, 2009
• Acceptance Date: Nov 1, 2009
• Publication Date: Nov 15, 2009
• Deposit Date: Apr 17, 2018
• Publicly Available Date: Apr 18, 2018
• Book Title: Proceedings of the British Pharmacological Society
• Keywords: Immunology,
• Public URL: http://researchrepository.napier.ac.uk/Output/1155509
• Related Public URLs: http://www.pa2online.org/abstract/abstract.jsp?abid=29438&kw=Immunomodulatory%20effects%20of%20cannabinoids%20in%20human%20T-lymphocytes&cat=-1&period=-1
• Contract Date: Apr 17, 2018