The theoretical approach to population genetics (2018)
Journal Article
Al Ghafri, M. K. (2018). The theoretical approach to population genetics. Ology: Reviews in Applied Sciences, 1, 10-11. https://doi.org/10.14297/ras.v1i1.3

Population genetics is the study of gene variation within or between populations. It deals with the allele frequencies in a given population and the forces, which might change this. Such forces, which are known to alter and change the allele frequenc... Read More about The theoretical approach to population genetics.

In utero androgen administration induces changes in gene expression and purkinje cell development in the cerebellum (2015)
Thesis
Wilson, L. M. In utero androgen administration induces changes in gene expression and purkinje cell development in the cerebellum. (Thesis). Edinburgh Napier University. http://researchrepository.napier.ac.uk/id/eprint/8867

Steroids play a major role in the development of the CNS with those brain areas involved in sexual behaviour having been the focus of most neuroendocrine studies to date e.g. the hypothalamus and pituitary gland (Feist and Schreck, 1996; Mong, et al.... Read More about In utero androgen administration induces changes in gene expression and purkinje cell development in the cerebellum.

The role of protein phosphatase PP2ACdc55 during meiosis in Saccharomyces cerevisiae (2013)
Thesis
Kerr, G. The role of protein phosphatase PP2ACdc55 during meiosis in Saccharomyces cerevisiae. (Thesis). University of Warwick. http://researchrepository.napier.ac.uk/Output/1596320

Meiosis is a specialised cell division that results in the formation of four genetically unique haploid daughter cells from one diploid parent cell. This is achieved by one round of DNA replication followed by two rounds of nuclear division. This is... Read More about The role of protein phosphatase PP2ACdc55 during meiosis in Saccharomyces cerevisiae.

Starvation/stationary phase survival of Rhodococcus erythropolis SQ1: a physiological and genetic analysis (2008)
Thesis
Fanget, N. V. J. Starvation/stationary phase survival of Rhodococcus erythropolis SQ1: a physiological and genetic analysis. (Thesis). Napier University. http://researchrepository.napier.ac.uk/id/eprint/2432

Although the starvation or non-growth state is probably the most common physiological state of bacteria, it has been studied in relatively few organisms. In spite of its importance in pathogenesis, bioremediation and several industrial processes, lim... Read More about Starvation/stationary phase survival of Rhodococcus erythropolis SQ1: a physiological and genetic analysis.

Characterisation of glutamine fructose-6-phosphate amidotransferase (EC 2.6.1.16) and N-acetylglucosamine metabolism in Bifidobacterium (2007)
Journal Article
Aïssi, E., Foley, S., Stolarczyk, E., Mouni, F., Brassart, C., Vidal, O., Aissi, E., Bouquelet, S., & Krzewinski, F. (2008). Characterisation of glutamine fructose-6-phosphate amidotransferase (EC 2.6.1.16) and N-acetylglucosamine metabolism in Bifidobacterium. Archives of Microbiology, 189(2), 157-167. https://doi.org/10.1007/s00203-007-0307-9

Bifidobacterium bifidum, in contrast to other bifido-bacterial species, is auxotrophic for N-acetylglucosamine. Growth experiments revealed assimilation of radiolabelled N-acetylglucosamine in bacterial cell walls and in acetate, an end-product of ce... Read More about Characterisation of glutamine fructose-6-phosphate amidotransferase (EC 2.6.1.16) and N-acetylglucosamine metabolism in Bifidobacterium.

Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells (2007)
Journal Article
Crevel, G., Hashimoto, R., Vass, S., Sherkow, J., Yamaguchi, M., Heck, M. M., & Cotterill, S. (2007). Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells. PLOS ONE, 2(9), Article e833. https://doi.org/10.1371/journal.pone.0000833

Background

The MCM2-7 proteins are crucial components of the pre replication complex (preRC) in eukaryotes. Since they are significantly more abundant than other preRC components, we were interested in determining whether the entire cellular conte... Read More about Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells.

Chemical Genetics Approach to Identify Peptide Ligands that Selectively Stimulate DAPK-1 Kinase Activity (2007)
Journal Article
Fraser, J. A., & Hupp, T. R. (2007). Chemical Genetics Approach to Identify Peptide Ligands that Selectively Stimulate DAPK-1 Kinase Activity. Biochemistry, 46(10), 2655-2673. https://doi.org/10.1021/bi061562j

Dissection of signal transduction pathways has been advanced by classic genetic approaches including targeted gene deletion and siRNA-based inhibition of gene product synthesis. Chemical genetics is a biochemical approach to develop small peptide-mim... Read More about Chemical Genetics Approach to Identify Peptide Ligands that Selectively Stimulate DAPK-1 Kinase Activity.

A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis (2007)
Journal Article
Stevens, C., Lin, Y., Sanchez, M., Amin, E., Copson, E., White, H., Durston, V., Eccles, D. M., & Hupp, T. (2007). A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis. Journal of Biological Chemistry, 282(18), 13791-13803. https://doi.org/10.1074/jbc.m605649200

p53 is activated genetically by a set of kinases that are components of the calcium calmodulin kinase superfamily, including CHK2, AMP kinase, and DAPK-1. In dissecting the mechanism of DAPK-1 control, a novel mutation (N1347S) was identified in the... Read More about A Germ Line Mutation in the Death Domain of DAPK-1 Inactivates ERK-induced Apoptosis.

Gordonia defluvii sp. nov., an actinomycete isolated from activated sludge foam. (2006)
Journal Article
Soddell, J. A., Stainsby, F. M., Eales, K. L., Seviour, R. J., & Goodfellow, M. (2006). Gordonia defluvii sp. nov., an actinomycete isolated from activated sludge foam. International Journal of Systematic and Evolutionary Microbiology, 56, 2265-2269. https://doi.org/10.1099/ijs.0.64034-0

Three strains of non-motile, Gram-positive, filamentous actinomycetes, isolates J4T, J5 and J59, initially recognized microscopically in activated sludge foam by their distinctive branching patterns, were isolated by micromanipulation. The taxonomic... Read More about Gordonia defluvii sp. nov., an actinomycete isolated from activated sludge foam..

Animated interval scatter-plot views for the exploratory analysis of large scale microarray time-course data. (2005)
Journal Article
Craig, P., Kennedy, J., & Cumming, A. (2005). Animated interval scatter-plot views for the exploratory analysis of large scale microarray time-course data. Information Visualization, 4(3), 149-163. https://doi.org/10.1057/palgrave.ivs.9500101

Microarray technologies are a relatively new development that allow biologists to monitor the activity of thousands of genes (normally around 8,000) in parallel across multiple stages of a biological process. While this new perspective on biological... Read More about Animated interval scatter-plot views for the exploratory analysis of large scale microarray time-course data..

TNF-α induced DNA damage in primary murine hepatocytes (2003)
Journal Article
Chan, Y.-S., Gillies, S., Ross, J., Harrison, D., Wheelhouse, N., Chan, Y.-S., Gillies, S. E., Caldwell, H., Ross, J. A., Harrison, D. J., & Prost, S. (2003). TNF-α induced DNA damage in primary murine hepatocytes. International Journal of Molecular Medicine, 12(6), 889-894. https://doi.org/10.3892/ijmm.12.6.889

Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, usually arising from a background of chronic inflammatory disease. Tumor necrosis factor alpha (TNF-alpha) is a pro-inflammatory cytokine produced in response to tissue injur... Read More about TNF-α induced DNA damage in primary murine hepatocytes.

Cellular responses of developing Fucus serratus embryos exposed to elevated concentrations of Cu2+. (2003)
Journal Article
Nielsen, H. D., Brown, M. T., & Brownlee, C. (2003). Cellular responses of developing Fucus serratus embryos exposed to elevated concentrations of Cu2+. Plant, Cell and Environment, 26(10), 1737-1747. https://doi.org/10.1046/j.1365-3040.2003.01091.x

Elevated concentrations of Cu2+ can have inhibitory effects on early development in plants and algae by targeting specific cellular processes. In the present study the effects of elevated Cu2+ on developmental processes in embryos of the brown algae... Read More about Cellular responses of developing Fucus serratus embryos exposed to elevated concentrations of Cu2+..

Analysis of the elements of catabolite repression in Clostridium acetobutylicum. (2003)
Journal Article
Tangney, M., Deutscher, J., Galinier, A., & Mitchell, W. J. (2003). Analysis of the elements of catabolite repression in Clostridium acetobutylicum. Journal of Molecular Microbiology and Biotechnology, 6, 6-11. https://doi.org/10.1159/000073403

The ptsH gene, encoding the phosphotransferase protein HPr, from Clostridium acetobutylicum ATCC 824 was identified from the genome sequence, cloned and shown to complement a ptsH mutant of Escherichia coli. The deduced protein sequence shares signif... Read More about Analysis of the elements of catabolite repression in Clostridium acetobutylicum..

DNA-Binding Activity of the Streptococcus thermophilus Phage Sfi21 Repressor (2002)
Journal Article
Bruttin, A., Foley, S., & Brüssow, H. (2002). DNA-Binding Activity of the Streptococcus thermophilus Phage Sfi21 Repressor. Virology, 303(1), 100-109. https://doi.org/10.1006/viro.2002.1574

The cloned Streptococcus thermophilus phage Sfi21 repressor open reading frame (orf) 127 gp protects a cell against superinfection with the homologous temperate, but not against virulent phages. As demonstrated by DNase protection assay and gel shift... Read More about DNA-Binding Activity of the Streptococcus thermophilus Phage Sfi21 Repressor.

Lactobacillus helveticus ATCC15009 as a host for native and conjugative plasmid DNA. (2002)
Book Chapter
Thompson, K., Collins, M. A., & Foley, S. (2002). Lactobacillus helveticus ATCC15009 as a host for native and conjugative plasmid DNA. In S. G. Pandalai (Ed.), Recent Research Developments in Plasmid Biology (55-74). Research Signpost/Transworld Research Network

The plasmid complement of Lactobacillus helveticus ATCC15009 (plasmids pLH1, pLH2 and pLH3) has been sequenced and is being analysed for functional properties. Sequences used include Accession Numbers X62150 (1-427), X72021 (21-2404 and 6891-10334),... Read More about Lactobacillus helveticus ATCC15009 as a host for native and conjugative plasmid DNA..

Transcription Mapping as a Tool in Phage Genomics: The Case of the Temperate Streptococcus thermophilus Phage Sfi21 (2002)
Journal Article
Ventura, M., Foley, S., Bruttin, A., Chennoufi, S. C., Canchaya, C., & Brüssow, H. (2002). Transcription Mapping as a Tool in Phage Genomics: The Case of the Temperate Streptococcus thermophilus Phage Sfi21. Virology, 296(1), 62-76. https://doi.org/10.1006/viro.2001.1331

For the lytic growth cycle of the temperate cos-site Streptococcus thermophilus phage Sfi21 a transcription map was developed on the basis of systematic Northern blot hybridizations. All deduced 5′ ends were confirmed by primer extension analysis. Th... Read More about Transcription Mapping as a Tool in Phage Genomics: The Case of the Temperate Streptococcus thermophilus Phage Sfi21.

Genomics, molecular genetics and the food industry (2000)
Journal Article
Pridmore, R., Crouzillat, D., Walker, C., Foley, S., Zink, R., Zwahlen, M.-C., Brüssow, H., Pétiard, V., & Mollet, B. (2000). Genomics, molecular genetics and the food industry. Journal of Biotechnology, 78(3), 251-258. https://doi.org/10.1016/s0168-1656%2800%2900202-9

The production of foods for an increasingly informed and selective consumer requires the coordinated activities of
the various branches of the food chain in order to provide convenient, wholesome, tasty, safe and affordable foods.
Also, the size an... Read More about Genomics, molecular genetics and the food industry.

Molecular Analysis of the Replication Origin of the Lactococcus lactis Plasmid pCI305 (1996)
Journal Article
Foley, S., Bron, S., Venema, G., Daly, C., & Fitzgerald, G. F. (1996). Molecular Analysis of the Replication Origin of the Lactococcus lactis Plasmid pCI305. Plasmid, 36(2), 125-141. https://doi.org/10.1006/plas.1996.0040

The replication origin region, ori, of the Lactococcus lactis subsp. lactis plasmid pCI305
contains three-and-one-half directly repeated 22-bp sequences and two inverted repeat sequences,
IR1 and IR2. These inverted repeat sequences overlap the pro... Read More about Molecular Analysis of the Replication Origin of the Lactococcus lactis Plasmid pCI305.

Alternative Splicing of a 51-Nucleotide Exon that Encodes a Putative Protein Kinase C Phosphorylation Site Generates Two Forms of the Chicken γ-Aminobutyric AcidAReceptor β2 Subunit (1994)
Journal Article
Harvey, R. J., Chinchetru, M. A., & Darlison, M. G. (1994). Alternative Splicing of a 51-Nucleotide Exon that Encodes a Putative Protein Kinase C Phosphorylation Site Generates Two Forms of the Chicken γ-Aminobutyric AcidAReceptor β2 Subunit. Journal of Neurochemistry, 62(1), 10-16. https://doi.org/10.1046/j.1471-4159.1994.62010010.x

Complementary DNAs that encode two forms of the chicken -γ-aminobutyric acid type A (GABAA) receptor β2 subunit have been isolated. These polypeptides differ by the presence (β2L) or absence (β2S) of 17 amino acids, which contain a possible target fo... Read More about Alternative Splicing of a 51-Nucleotide Exon that Encodes a Putative Protein Kinase C Phosphorylation Site Generates Two Forms of the Chicken γ-Aminobutyric AcidAReceptor β2 Subunit.

Molecular cloning reveals the existence of a fourth γ subunit of the vertebrate brain GABAAreceptor (1993)
Journal Article
Harvey, R. J., Kim, H.-C., & Darlison, M. G. (1993). Molecular cloning reveals the existence of a fourth γ subunit of the vertebrate brain GABAAreceptor. FEBS Letters, 331(3), 211-216. https://doi.org/10.1016/0014-5793%2893%2980339-v

We have isolated a cDNA, from the chicken, that encodes a fourth type of γ subunit of the vertebrate brain GABAA receptor. The mature polypeptide (which we name γ4) displays 67%, 69% and 70% identity, respectively, to the rat γ1, γ2 and γ3 subunits.... Read More about Molecular cloning reveals the existence of a fourth γ subunit of the vertebrate brain GABAAreceptor.