C A Notley
Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells
Notley, C A; Brown, M A; Wright, G P; Ehrenstein, M R
Abstract
The clearance of dying cells is vital for re-establishing tolerance during inflammation and has potent immunoregulatory consequences. Because natural IgM plays a key role in the removal of apoptotic cells, we investigated whether the immune modulatory properties of apoptotic cells depended on its presence. Using an Ab-independent, Ag-induced model of inflammatory arthritis, we tested whether natural IgM is essential for the arthritis-suppressing properties of apoptotic cells. Whereas administration of apoptotic cells reduced joint inflammation and damage in normal mice accompanied by suppression of the Th17 response, no protection was afforded in secreted IgM-deficient (Sμ–) mice. The enhanced production of IL-10 by T cells from draining lymph nodes and splenic marginal zone B cells, driven by the infusion of apoptotic cells, was abrogated in the absence of natural IgM. Apoptotic cells were present shortly after administration in the splenic marginal zone, but their removal was substantially delayed in the absence of natural IgM. Incubation of apoptotic cells with natural IgM in vitro restored their arthritis-suppressing properties in Sμ– mice. Moreover, these IgM-coated apoptotic cells were cleared rapidly after injection from the spleens of Sμ– mice. Our results demonstrate that natural IgM is a critical factor in a chain of events triggered by the administration of apoptotic cells that promote IL-10–secreting B and T cells and restrain the development of inflammation.
Citation
Notley, C. A., Brown, M. A., Wright, G. P., & Ehrenstein, M. R. (2011). Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells. The journal of immunology : official journal of the American Association of Immunologists, 186(8), 4967-4972. https://doi.org/10.4049/jimmunol.1003021
Journal Article Type | Article |
---|---|
Online Publication Date | Mar 7, 2011 |
Publication Date | Apr 15, 2011 |
Deposit Date | Aug 1, 2016 |
Journal | The Journal of Immunology |
Electronic ISSN | 0022-1767 |
Publisher | American Association of Immunologists |
Peer Reviewed | Peer Reviewed |
Volume | 186 |
Issue | 8 |
Pages | 4967-4972 |
DOI | https://doi.org/10.4049/jimmunol.1003021 |
Keywords | Apoptotic cells, IgM, arthritis, inflammation, |
Public URL | http://researchrepository.napier.ac.uk/Output/320481 |
You might also like
Belonging to a learning community: staff perspectives.
(2018)
Presentation / Conference Contribution
MS TCR Therapy
(2018)
Patent
Engineering Specificity and Function of Therapeutic Regulatory T Cells
(2017)
Journal Article
Downloadable Citations
About Edinburgh Napier Research Repository
Administrator e-mail: repository@napier.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2025
Advanced Search