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Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction

Lin, Yao; Hupp, Ted R.; Stevens, Craig

Authors

Yao Lin

Ted R. Hupp



Abstract

Death-associated protein kinase (DAPK) is a stress-regulated protein
kinase that mediates a range of processes, including signal-induced cell death and autophagy. Although the kinase domain of DAPK has a range of substrates that mediate its signalling, the additional protein interaction domains of DAPK are relatively ill defined. This review will summarize our current knowledge of the DAPK interactome, the use of peptide aptamers to define novel protein–protein interaction motifs, and how these new protein–protein interactions give insight into DAPK functions in diverse cellular processes, including growth factor signalling, the regulation of autophagy, and its emerging role in the regulation of immune responses.

Citation

Lin, Y., Hupp, T. R., & Stevens, C. (2010). Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death: DAPK and signal transduction. FEBS Journal, 277(1), 48-57. https://doi.org/10.1111/j.1742-4658.2009.07411.x

Journal Article Type Article
Acceptance Date Sep 8, 2009
Online Publication Date Oct 30, 2009
Publication Date 2010-01
Deposit Date Aug 29, 2018
Journal FEBS Journal
Print ISSN 1742-464X
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 277
Issue 1
Pages 48-57
DOI https://doi.org/10.1111/j.1742-4658.2009.07411.x
Keywords autophagy; DAPK; growth factor; immune response; interactome; kinase; mTOR; peptide
Public URL http://researchrepository.napier.ac.uk/Output/1287258