Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum (1992)
Journal Article
Austin, M.-P., Dougall, N., Ross, M., Murray, C., O'Carroll, R. E., Moffoot, A., Ebmeier, K. P., & Goodwin, G. M. (1992). Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum. Journal of Affective Disorders, 26(1), 31-43. https://doi.org/10.1016/0165-0327%2892%2990032-2

Forty patients with a major depressive episode were investigated at rest using Single Photon Emission Tomography (SPET or SPECT) with 99mTc-exametazime, an intravenous ligand taken into brain in proportion to regional cerebral blood flow, thereby pro... Read More about Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum.

QALYs in mental health: a case study (1992)
Journal Article
Wilkinson, G., Williams, B., Krekorian, H., McLees, S., & Falloon, I. (1992). QALYs in mental health: a case study. Psychological Medicine, 22(3), 725. https://doi.org/10.1017/S0033291700038162

The applicability of the Charing Cross health indicator (CH-X) to the field of mental health was investigated in a community setting using descriptive statistics and principal components analysis. The CH-X is based on assessments of (i) distress and... Read More about QALYs in mental health: a case study.

A computer-based microworld for the assessment and remediation of sentence processing deficits in aphasia. (1991)
Thesis
Crerar, M. A. A computer-based microworld for the assessment and remediation of sentence processing deficits in aphasia. (Thesis). Edinburgh Napier University. http://researchrepository.napier.ac.uk/id/eprint/4968

This thesis investigates impairments of written sentence comprehension in 14
aphasic adults. The primary purpose of the research was to apply computer
technology to the process of assessment, with the aim of improving diagnostic
precision and ther... Read More about A computer-based microworld for the assessment and remediation of sentence processing deficits in aphasia..

Structural Characteristics of Cation and Anion Channels Directly Operated by Agonists (1989)
Book Chapter
Barnard, E., Darlison, M., Marshall, J., & Sattelle, D. (1989). Structural Characteristics of Cation and Anion Channels Directly Operated by Agonists. In Ion Transport (159-181). Academic Press. https://doi.org/10.1016/b978-0-12-403985-8.50016-8

No abstract available.

Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer (1989)
Journal Article
Wisden, W., McNaughton, L. A., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1989). Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer. Neuroscience Letters, 106(1-2), 7-12. https://doi.org/10.1016/0304-3940%2889%2990193-6

Using in situ hybridization histochemistry, we have demonstrated that 3 α subunit mRNAs of the {GABAA} receptor are present in different cell populations of the bovine cerebellum. While the α1 mRNA is the most abundant and is present in granule cells... Read More about Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer.

Localization of GABAA receptor α-subunit mRNAs in relation to receptor subtypes (1989)
Journal Article
Wisden, W., Morris, B. J., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1989). Localization of GABAA receptor α-subunit mRNAs in relation to receptor subtypes. Molecular Brain Research, 5(4), 305-310. https://doi.org/10.1016/0169-328x%2889%2990065-x

The distribution of 3 {GABAA} receptor α-subunit mRNAs in various regions of bovine brain has been investigated using in situ hybridization. Whereas the α2- and α3-transcripts are of low abundance in all regions except striatum, the α1-transcript is... Read More about Localization of GABAA receptor α-subunit mRNAs in relation to receptor subtypes.

Brain α-Neurotoxin-Binding Proteins and Nicotinic Acetylcholine Receptors (1988)
Book Chapter
Darlison, M. G., Hicks, A. A., Cockcroft, V. B., Squire, M. D., & Barnard, E. A. (1988). Brain α-Neurotoxin-Binding Proteins and Nicotinic Acetylcholine Receptors. In Cellular and Molecular Basis of Synaptic Transmission (475-492). Springer. https://doi.org/10.1007/978-3-642-73172-3_32

The study of the nicotinic acetylcholine receptor (AChR) of skeletal muscle and fish electric organ has been greatly facilitated by the application of the α-neurotoxins (postsynaptic toxins) of elapid and hydrophid snake venoms, such as α-bungarotoxi... Read More about Brain α-Neurotoxin-Binding Proteins and Nicotinic Acetylcholine Receptors.

Distinct GABAA receptor α subunit mRNAs show differential patterns of expression in bovine brain (1988)
Journal Article
Wisden, W., Morris, B. J., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1988). Distinct GABAA receptor α subunit mRNAs show differential patterns of expression in bovine brain. Neuron, 1(10), 937-947. https://doi.org/10.1016/0896-6273%2888%2990151-1

Specific oligonucleotide probes have been used to visualize the regional and cellular distribution of the mRNAs encoding three structurally distinct GABA A receptor α subunits in bovine brain. In situ hybridization analysis showed that these transcri... Read More about Distinct GABAA receptor α subunit mRNAs show differential patterns of expression in bovine brain.

Structural and functional basis for GABAA receptor heterogeneity (1988)
Journal Article
Levitan, E. S., Schofield, P. R., Burt, D. R., Rhee, L. M., Wisden, W., Köhler, M., Fujita, N., Rodriguez, H. F., Stephenson, A., Darlison, M. G., Barnard, E. A., & Seeburg, P. H. (1988). Structural and functional basis for GABAA receptor heterogeneity. Nature, 335(6185), 76-79. https://doi.org/10.1038/335076a0

When γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in vertebrate brain, binds to its receptor it activates a chloride channel. Neurotransmitter action at the GABAA receptor is potentiated by both benzodiazepines and barbiturates w... Read More about Structural and functional basis for GABAA receptor heterogeneity.

Molecular biology of the GABAA receptor: the receptor/channel superfamily (1987)
Journal Article
Barnard, E. A., Darlison, M. G., & Seeburg, P. (1987). Molecular biology of the GABAA receptor: the receptor/channel superfamily. Trends in Neurosciences, 10(12), 502-509. https://doi.org/10.1016/0166-2236%2887%2990130-5

Complementary DNAs encoding the two subunit types of the brain GABAA receptor have been cloned, revealing its full protein primary structure1. In another laboratory, the same point has now been reached for one of the subunits of the spinal cord glyci... Read More about Molecular biology of the GABAA receptor: the receptor/channel superfamily.

Cloning and sequence analysis of the pyruvate and 2-oxoglutarate dehydrogenase complex genes ofEscherichia coli (1984)
Journal Article
Guest, J. R., Darlison, M. G., Spencer, M. E., & Stephens, P. E. (1984). Cloning and sequence analysis of the pyruvate and 2-oxoglutarate dehydrogenase complex genes ofEscherichia coli. Biochemical Society Transactions, 12(2), 220-223. https://doi.org/10.1042/bst0120220

No abstract available.