Localization of GABAA receptor α-subunit mRNAs in relation to receptor subtypes

Wisden, William; Morris, Brian J.; Darlison, Mark G.; Hunt, Stephen P.; Barnard, Eric A.

Abstract

The distribution of 3 {GABAA} receptor α-subunit mRNAs in various regions of bovine brain has been investigated using in situ hybridization. Whereas the α2- and α3-transcripts are of low abundance in all regions except striatum, the α1-transcript is considerably enriched in the inferior colliculus, olfactory bulb and substantia nigra, and appears to be correlated with benzodiazepine type I receptor localization.

Citation

Wisden, W., Morris, B. J., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1989). Localization of GABAA receptor α-subunit mRNAs in relation to receptor subtypes. Molecular Brain Research, 5(4), 305-310. https://doi.org/10.1016/0169-328x%2889%2990065-x

• Journal Article Type: Article
• Acceptance Date: Jan 17, 1989
• Publication Date: 1989-06
• Deposit Date: Jul 27, 2016
• Journal: Molecular Brain Research
• Print ISSN: 0169-328X
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 5
• Issue: 4
• Pages: 305-310
• DOI: https://doi.org/10.1016/0169-328x%2889%2990065-x
• Keywords: GABAA receptor,Receptor subtype,In situ hybridization,Colliculus,Olfactory bulb, Striatum, Midbrain,
• Public URL: http://researchrepository.napier.ac.uk/Output/317356
• Publisher URL: http://www.sciencedirect.com/science/article/pii/0169328X8990065X