Molecular biology of the GABAA receptor: the receptor/channel superfamily

Barnard, Eric A.; Darlison, Mark G.; Seeburg, Peter

Abstract

Complementary DNAs encoding the two subunit types of the brain GABAA receptor have been cloned, revealing its full protein primary structure1. In another laboratory, the same point has now been reached for one of the subunits of the spinal cord glycine receptor2. It is illuminating to compare these sequences and those of the nicotinic acetylcholine receptor. All of these receptors, in which an ion channel is directly gated by the binding of the transmitter, are deducéd to be members of a receptor superfamily and exhibit some striking common features in their architecture

Citation

Barnard, E. A., Darlison, M. G., & Seeburg, P. (1987). Molecular biology of the GABAA receptor: the receptor/channel superfamily. Trends in Neurosciences, 10(12), 502-509. https://doi.org/10.1016/0166-2236%2887%2990130-5

• Journal Article Type: Article
• Acceptance Date: Dec 1, 1987
• Publication Date: 1987-12
• Deposit Date: Aug 5, 2016
• Journal: Trends in Neurosciences
• Print ISSN: 0166-2236
• Electronic ISSN: 1878-108X
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 12
• Pages: 502-509
• DOI: https://doi.org/10.1016/0166-2236%2887%2990130-5
• Keywords: Neuroscience(all)
• Public URL: http://researchrepository.napier.ac.uk/Output/327829