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Distinct GABAA receptor α subunit mRNAs show differential patterns of expression in bovine brain

Wisden, William; Morris, Brian J.; Darlison, Mark G.; Hunt, Stephen P.; Barnard, Eric A.

Authors

William Wisden

Brian J. Morris

Mark G. Darlison

Stephen P. Hunt

Eric A. Barnard



Abstract

Specific oligonucleotide probes have been used to visualize the regional and cellular distribution of the mRNAs encoding three structurally distinct GABA A receptor α subunits in bovine brain. In situ hybridization analysis showed that these transcripts differ in distribution and in relative abundance. In frontal cortex the α1 and α2 transcripts are most abundant in layers II–IV, whereas the α3 mRNA is most abundant in layers V and VI. In the hippocampal complex, the α transcripts are differentially distributed in the entorhinal cortex and subiculum. The α2 transcript is enriched in the dentate gyrus and Math Eq regions of the hippocampus. In the cerebellum, essentially only the α1 transcript is detectable in granule cells, Purkinje cells, and stellate/basket cells. These results suggest that the different α subunits represent components of distinct GABA A receptor subtypes.

Citation

Wisden, W., Morris, B. J., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1988). Distinct GABAA receptor α subunit mRNAs show differential patterns of expression in bovine brain. Neuron, 1(10), 937-947. https://doi.org/10.1016/0896-6273%2888%2990151-1

Journal Article Type Article
Acceptance Date Dec 1, 1988
Publication Date 1988-12
Deposit Date Aug 5, 2016
Journal Neuron
Print ISSN 0896-6273
Electronic ISSN 1097-4199
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 1
Issue 10
Pages 937-947
DOI https://doi.org/10.1016/0896-6273%2888%2990151-1
Keywords Neuroscience(all)
Public URL http://researchrepository.napier.ac.uk/Output/327856






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