William Wisden
Distinct GABAA receptor α subunit mRNAs show differential patterns of expression in bovine brain
Wisden, William; Morris, Brian J.; Darlison, Mark G.; Hunt, Stephen P.; Barnard, Eric A.
Authors
Brian J. Morris
Mark G. Darlison
Stephen P. Hunt
Eric A. Barnard
Abstract
Specific oligonucleotide probes have been used to visualize the regional and cellular distribution of the mRNAs encoding three structurally distinct GABA A receptor α subunits in bovine brain. In situ hybridization analysis showed that these transcripts differ in distribution and in relative abundance. In frontal cortex the α1 and α2 transcripts are most abundant in layers II–IV, whereas the α3 mRNA is most abundant in layers V and VI. In the hippocampal complex, the α transcripts are differentially distributed in the entorhinal cortex and subiculum. The α2 transcript is enriched in the dentate gyrus and Math Eq regions of the hippocampus. In the cerebellum, essentially only the α1 transcript is detectable in granule cells, Purkinje cells, and stellate/basket cells. These results suggest that the different α subunits represent components of distinct GABA A receptor subtypes.
Citation
Wisden, W., Morris, B. J., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1988). Distinct GABAA receptor α subunit mRNAs show differential patterns of expression in bovine brain. Neuron, 1(10), 937-947. https://doi.org/10.1016/0896-6273%2888%2990151-1
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 1, 1988 |
Publication Date | 1988-12 |
Deposit Date | Aug 5, 2016 |
Journal | Neuron |
Print ISSN | 0896-6273 |
Electronic ISSN | 1097-4199 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 1 |
Issue | 10 |
Pages | 937-947 |
DOI | https://doi.org/10.1016/0896-6273%2888%2990151-1 |
Keywords | Neuroscience(all) |
Public URL | http://researchrepository.napier.ac.uk/Output/327856 |
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