Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer

Wisden, William; McNaughton, Linda A.; Darlison, Mark G.; Hunt, Stephen P.; Barnard, Eric A.

Abstract

Using in situ hybridization histochemistry, we have demonstrated that 3 α subunit mRNAs of the {GABAA} receptor are present in different cell populations of the bovine cerebellum. While the α1 mRNA is the most abundant and is present in granule cells, Purkinje cells and stellate/basket cells, the α2 mRNA appears to be confined to the Bergmann glial cell layer. The α3 mRNA is only expressed in the Golgi cells. This differential distribution of {GABAA} receptor mRNA subtypes suggests a previously unrecognized complexity of {GABAergic} transmission in the cerebellum.

Citation

Wisden, W., McNaughton, L. A., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1989). Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer. Neuroscience Letters, 106(1-2), 7-12. https://doi.org/10.1016/0304-3940%2889%2990193-6

• Journal Article Type: Article
• Acceptance Date: Jul 13, 1989
• Publication Date: 1989-11
• Deposit Date: Jul 27, 2016
• Journal: Neuroscience Letters
• Print ISSN: 0304-3940
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 106
• Issue: 1-2
• Pages: 7-12
• DOI: https://doi.org/10.1016/0304-3940%2889%2990193-6
• Keywords: In situ hybridization, Cerebellum, γ-Aminobutyric acid-A receptor, Bergmann glia,
• Public URL: http://researchrepository.napier.ac.uk/Output/317382
• Publisher URL: http://www.sciencedirect.com/science/article/pii/0304394089901936