Characterisation of GABAA receptors and cation-chloride cotransporters in the uterus and their role in pre-term labour (2018)
Thesis
Sutherland, M. L. Characterisation of GABAA receptors and cation-chloride cotransporters in the uterus and their role in pre-term labour. (Thesis). Edinburgh napier University. http://researchrepository.napier.ac.uk/Output/1255142

GABAA receptor (GABAAR) function may be inhibitory or excitatory in the brain depending on the chloride electrochemical gradient over the neuronal membrane. This gradient is tightly regulated by cation-chloride transporter (CCC) expression.
Prematur... Read More about Characterisation of GABAA receptors and cation-chloride cotransporters in the uterus and their role in pre-term labour.

Interpersonal trauma, substance misuse and pregnancy: A phenomenological exploration of pregnant women and midwives in Scotland (2018)
Thesis
Waddell, N. M. Interpersonal trauma, substance misuse and pregnancy: A phenomenological exploration of pregnant women and midwives in Scotland. (Thesis). Edinburgh Napier University. http://researchrepository.napier.ac.uk/Output/1255223

Background: The relationship between interpersonal trauma (IPT) and substance misuse is complex and multi-factorial, but has not been examined fully in the existing few studies involving pregnant women who misuse substances. UK based midwifery educat... Read More about Interpersonal trauma, substance misuse and pregnancy: A phenomenological exploration of pregnant women and midwives in Scotland.

Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment (2018)
Journal Article
Ahmad, S. F., Brown, J. K., Campbell, L. L., Koscielniak, M., Oliver, C., Wheelhouse, N., Entrican, G., McFee, S., Wills, G. S., McClure, M. O., Horner, P. J., Gaikoumelou, S., Lee, K. F., Critchley, H. O., Duncan, W. C., & Horne, A. W. (2018). Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment. EBioMedicine, 29, 159-165. https://doi.org/10.1016/j.ebiom.2018.02.020

Tubal ectopic pregnancies are a leading cause of global maternal morbidity and mortality. Previous infection with Chlamydia trachomatis is a major risk factor for tubal embryo implantation but the biological mechanism behind this association is uncle... Read More about Pelvic Chlamydial Infection Predisposes to Ectopic Pregnancy by Upregulating Integrin β1 to Promote Embryo-tubal Attachment.

Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release (2017)
Journal Article
Giakoumelou, S., Wheelhouse, N., Brown, J., Wade, J., Simitsidellis, I., Gibson, D., Saunders, P. T. K., Horner, P., Entrican, G., Howie, S. E. M., & Horne, A. W. (2017). Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release. Scientific Reports, 7(1), Article 2001. https://doi.org/10.1038/s41598-017-02223-z

Miscarriage affects ~20% of pregnancies and 30 maternal infections account for ~15% of early miscarriages. Chlamydia trachomatis (Ct) has been associated with miscarriage but the underlying mechanisms are unknown. Successful implantation requires end... Read More about Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release.

Coded rhetoric: The reality of midwifery practice (2016)
Journal Article
Group, B. P., Mander, R., & McHugh, N. (2016). Coded rhetoric: The reality of midwifery practice. British Journal of Midwifery, 24(5), 344-352. https://doi.org/10.12968/bjom.2016.24.5.344

In the light of certain failings in NHS provision of care, the Nursing and Midwifery Council's (NMC, 2015) Code requires staff to engage more effectively with patients and service users. An online survey was undertaken by the Birth Project Group to a... Read More about Coded rhetoric: The reality of midwifery practice.

The role of infection in miscarriage (2015)
Journal Article
Giakoumelou, S., Wheelhouse, N., Cuschieri, K., Entrican, G., Howie, S. E., & Horne, A. W. (2016). The role of infection in miscarriage. Human Reproduction Update, 22(1), 116-133. https://doi.org/10.1093/humupd/dmv041

BACKGROUND: Miscarriage is the spontaneous loss of a pregnancy before 12 weeks (early miscarriage) or from 12 to 24 weeks (late miscarriage) of gestation. Miscarriage occurs in one in five pregnancies and can have considerable physiological and psych... Read More about The role of infection in miscarriage.

In an ovine model of polycystic ovary syndrome (PCOS) prenatal androgens suppress female fetal renal gluconeogenesis. (2015)
Journal Article
Kanellopoulos-Langevin, C., Connolly, F., Rae, M. T., Späth, K., Boswell, L., McNeilly, A. S., & Duncan, W. C. (2015). In an ovine model of polycystic ovary syndrome (PCOS) prenatal androgens suppress female fetal renal gluconeogenesis. PLOS ONE, 10, Article e0132113. https://doi.org/10.1371/journal.pone.0132113

Increased maternal androgen exposure during pregnancy programmes a polycystic ovary syndrome (PCOS)-like condition, with metabolic dysfunction, in adult female offspring. Other in utero exposures associated with the development of insulin resistance,... Read More about In an ovine model of polycystic ovary syndrome (PCOS) prenatal androgens suppress female fetal renal gluconeogenesis..

Pancreatic and adrenal development and function in an ovine model of polycystic ovary syndrome (2015)
Thesis
Ramaswamy, S. Pancreatic and adrenal development and function in an ovine model of polycystic ovary syndrome. (Thesis). Edinburgh Napier University. http://researchrepository.napier.ac.uk/id/eprint/9826

Polycystic Ovary Syndrome (PCOS) is a complex disorder encompassing reproductive and metabolic dysfunction. Ovarian hyperandrogenism is an endocrine hallmark of human PCOS. In animal models, PCOS-like abnormalities can be recreated by in utero over-e... Read More about Pancreatic and adrenal development and function in an ovine model of polycystic ovary syndrome.

Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development (2014)
Journal Article
Girardi, G., Fraser, J., Lennen, R., Vontell, R., Jansen, M., & Hutchison, G. (2015). Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development. Molecular Psychiatry, 20(8), 1017-1026. https://doi.org/10.1038/mp.2014.110

In the current study, we have developed a magnetic resonance imaging-based method for non-invasive detection of
complement activation in placenta and foetal brain in vivo in utero. Using this method, we found that anti-complement
C3-targeted ultras... Read More about Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development.

A focus group study exploring gynecological cancer survivors’ experiences and perceptions of participating in a RCT testing the efficacy of a home-based physical activity intervention (2013)
Journal Article
Donnelly, C. M., Lowe-Strong, A., Rankin, J. P., Campbell, A., Blaney, J. M., & Gracey, J. H. (2013). A focus group study exploring gynecological cancer survivors’ experiences and perceptions of participating in a RCT testing the efficacy of a home-based physical activity intervention. Supportive Care in Cancer, 21(6), 1697-1708. https://doi.org/10.1007/s00520-012-1716-0

This study aims to explore gynecological cancer survivors' perceptions and experiences following participation in a randomised controlled trial (RCT) testing the efficacy of a home-based physical activity behavioral change intervention (Donnelly et a... Read More about A focus group study exploring gynecological cancer survivors’ experiences and perceptions of participating in a RCT testing the efficacy of a home-based physical activity intervention.

Is counselling necessary? Making the decision to have an abortion. A qualitative interview study (2012)
Journal Article
Brown, S. (2013). Is counselling necessary? Making the decision to have an abortion. A qualitative interview study. European Journal of Contraception and Reproductive Health Care, 18(1), 44-48. https://doi.org/10.3109/13625187.2012.750290

Objectives To explore young women’s decision-making about having an abortion, in particular, how they reached the decision and with whom they discussed it.
Methods Qualitative study comprising semi-structured one-to-one interviews with 24 women aged... Read More about Is counselling necessary? Making the decision to have an abortion. A qualitative interview study.

Cancer survivors' exercise barriers, facilitators and preferences in the context of fatigue, quality of life and physical activity participation: a questionnaire-survey: Cancer survivors' exercise barriers (2011)
Journal Article
Blaney, J. M., Lowe-Strong, A., Rankin-Watt, J., Campbell, A., & Gracey, J. H. (2013). Cancer survivors' exercise barriers, facilitators and preferences in the context of fatigue, quality of life and physical activity participation: a questionnaire-survey: Cancer survivors' exercise barriers. Psycho-Oncology, 22(1), 186-194. https://doi.org/10.1002/pon.2072

ObjectiveTo investigate the exercise barriers, facilitators and preferences of a mixed sample of cancer survivors as well as fatigue levels, quality of life (QoL) and the frequency and intensity of exercise that cancer survivors typically engage in.M... Read More about Cancer survivors' exercise barriers, facilitators and preferences in the context of fatigue, quality of life and physical activity participation: a questionnaire-survey: Cancer survivors' exercise barriers.

A randomised controlled trial testing the feasibility and efficacy of a physical activity behavioural change intervention in managing fatigue with gynaecological cancer survivors (2011)
Journal Article
Donnelly, C., Blaney, J., Lowe-Strong, A., Rankin, J., Campbell, A., McCrum-Gardner, E., & Gracey, J. (2011). A randomised controlled trial testing the feasibility and efficacy of a physical activity behavioural change intervention in managing fatigue with gynaecological cancer survivors. Gynecologic Oncology, 122(3), 618-624. https://doi.org/10.1016/j.ygyno.2011.05.029

Objective To determine the feasibility and efficacy of a physical activity behavioural change intervention in managing cancer-related fatigue among gynaecological cancer survivors during and post anti-cancer treatments. Methods A two arm, single blin... Read More about A randomised controlled trial testing the feasibility and efficacy of a physical activity behavioural change intervention in managing fatigue with gynaecological cancer survivors.

Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy (2010)
Journal Article
Shaw, J. L. V., Wills, G. S., Lee, K.-F., Horner, P. J., McClure, M. O., Abrahams, V. M., Wheelhouse, N., Jabbour, H. N., Critchley, H. O. D., Entrican, G., & Horne, A. W. (2011). Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy. American Journal of Pathology, 178(1), 253-260. https://doi.org/10.1016/j.ajpath.2010.11.019

Chlamydia trachomatis and smoking are major risk factors for tubal ectopic pregnancy (EP), but the underlying mechanisms of these associations are not completely understood. Fallopian tube (FT) from women with EP exhibit altered expression of prokine... Read More about Chlamydia trachomatis infection increases fallopian tube PROKR2 via TLR2 and NFκB activation resulting in a microenvironment predisposed to ectopic pregnancy.

Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube (2010)
Journal Article
Duncan, W. C., McDonald, S. E., Dickinson, R. E., Shaw, J. L. V., Lourenco, P. C., Wheelhouse, N., Lee, K.-F., Critchley, H. O. D., & Horne, A. W. (2010). Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube. Molecular Human Reproduction, 16, 950-959. https://doi.org/10.1093/molehr/gaq055

We investigated whether the repulsive SLIT/ROBO pathway is expressed in the endometrium and is negatively regulated during implantation. We also examined whether deficient expression in the Fallopian tube (FT) may predispose to ectopic pregnancy (EP)... Read More about Expression of the repulsive SLIT/ROBO pathway in the human endometrium and Fallopian tube.

Ovine trophoblast is a primary source of TNFalpha during Chlamydophila abortus infection. (2009)
Journal Article
Wheelhouse, N., Wattegedera, S., Stanton, J., Maley, S., Watson, D., Jepson, C., Deane, D., Buxton, D., Longbottom, D., Baszler, T., & Entrican, G. (2009). Ovine trophoblast is a primary source of TNFalpha during Chlamydophila abortus infection. Journal of Reproductive Immunology, 80(1-2), 49-56. https://doi.org/10.1016/j.jri.2008.12.003

Chlamydophila abortus is a Gram-negative obligate intracellular bacterium that causes infectious abortion in sheep (ovine enzootic abortion, OEA) and humans. Infected placentas recovered from sheep that experience OEA have thickened membranes, contai... Read More about Ovine trophoblast is a primary source of TNFalpha during Chlamydophila abortus infection..

Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection (2008)
Journal Article
King, A. E., Wheelhouse, N., Cameron, S., McDonald, S. E., Lee, K.-F., Entrican, G., Critchley, H. O. D., & Horne, A. W. (2009). Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection. Human Reproduction, 24(3), 679-686. https://doi.org/10.1093/humrep/den452

BACKGROUND: Secretory leukocyte protease inhibitor (SLPI) and elafin are anti-protease and anti-microbial molecules with a role in innate immune defence. They have been demonstrated at multiple mucosal surfaces including those of the female reproduct... Read More about Expression of secretory leukocyte protease inhibitor and elafin in human fallopian tube and in an in-vitro model of Chlamydia trachomatis infection.

Glucocorticoid receptor-mediated regulation of MMP9 gene expression in human ovarian surface epithelial cells (2008)
Journal Article
Rae, M. T., Price, D., Harlow, C. R., Critchley, H. O. D., & Hillier, S. G. (2009). Glucocorticoid receptor-mediated regulation of MMP9 gene expression in human ovarian surface epithelial cells. Fertility and Sterility, 92(2), 703-708. https://doi.org/10.1016/j.fertnstert.2008.06.040

Objective
To obtain proof-of-concept that locally produced anti-inflammatory steroids suppress ovulation-associated extracellular matrix proteases in human ovarian surface epithelial (OSE) cells.

Design
Primary OSE cell cultures treated with int... Read More about Glucocorticoid receptor-mediated regulation of MMP9 gene expression in human ovarian surface epithelial cells.

cAMP response element-binding (CREB) signalling and ovarian surface epithelial cell survival (2006)
Journal Article
Gubbay, O., Rae, M. T., McNeilly, A. S., Donadeu, F. X., Zeleznik, A. J., & Hillier, S. G. (2006). cAMP response element-binding (CREB) signalling and ovarian surface epithelial cell survival. Journal of Endocrinology, 191(1), 275-285. https://doi.org/10.1677/joe.1.06928

cAMP response-element binding (CREB) transcription factors transduce cell survival responses to peptide hormones and growth factors in normal tissues and mutant CREB proteins are implicated in tumorigenesis. Ovarian cancer most frequently arises from... Read More about cAMP response element-binding (CREB) signalling and ovarian surface epithelial cell survival.

Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas (2005)
Journal Article
Gubbay, O., Guo, W., Rae, M. T., Niven, D., Langdon, S. P., & Hillier, S. G. (2005). Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas. British Journal of Cancer, 92, 1927-1933. https://doi.org/10.1038/sj.bjc.6602568

Ovulation is believed to contribute to the development of ovarian cancers that derive from the ovarian surface epithelium (OSE). The process of ovulation is synonymous with inflammation and inflammatory cytokines such as interleukin-1α (IL-1α) have r... Read More about Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas.