FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression (2017)
Journal Article
Ikpegbu, E., Basta, L., Clements, D. N., Fleming, R., Vincent, T. L., Buttle, D. J., Pitsillides, A. A., Staines, K. A., & Farquharson, C. (2018). FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression. Journal of Cellular Physiology, 233(7), 5334-5347. https://doi.org/10.1002/jcp.26345

E11/podoplanin is critical in the early stages of osteoblast-to-osteocyte transitions (osteocytogenesis) however the upstream events which regulate E11 expression are unknown. The aim of this study was to examine the effects of FGF-2 on E11-mediated... Read More about FGF-2 promotes osteocyte differentiation through increased E11/podoplanin expression.

Sost deficiency does not alter bone’s lacunar or vascular porosity in mice (2017)
Journal Article
Mosey, H., Núñez, J. A., Goring, A., Clarkin, C. E., Staines, K. A., Lee, P. D., Pitsillides, A. A., & Javaheri, B. (2017). Sost deficiency does not alter bone’s lacunar or vascular porosity in mice. Frontiers in Materials, 4, Article 27. https://doi.org/10.3389/fmats.2017.00027

SCLEROSTIN (Sost) is expressed predominantly in osteocytes acting as a negative regulator of bone formation. In humans, mutations in the SOST gene lead to skeletal overgrowth and increased bone mineral density, suggesting that SCLEROSTIN is a key reg... Read More about Sost deficiency does not alter bone’s lacunar or vascular porosity in mice.

A distinctive patchy osteomalacia characterises Phospho1 -deficient mice (2017)
Journal Article
-deficient mice. Journal of Anatomy, 231(2), 298-308. https://doi.org/10.1111/joa.12628

The phosphatase PHOSPHO1 is involved in the initiation of biomineralisation. Bones in Phospho1 KO mice show histological osteomalacia with frequent bowing of long bones and spontaneous fractures: they contain less mineral, with smaller mineral crysta... Read More about A distinctive patchy osteomalacia characterises Phospho1 -deficient mice.

The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following (2017)
Presentation / Conference Contribution
Baudel, M., Rae, M., Fraser, J., & Poole, A. (2017, April). The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following. Presented at BNA 2017

Stroke is one of the major causes of death and disability worldwide. The harm caused by the interruption of blood flow to the brain unfolds in the subsequent hours and days, so it is critical to identify new therapeutic targets that could reduce neur... Read More about The expression of the chloride co-transporters NKCC1 and KCC2 is reversed in the penumbra following.

TetraploidSNPMap: Software for Linkage Analysis and QTL Mapping in Autotetraploid Populations Using SNP Dosage Data (2017)
Journal Article
Hackett, C. A., Boskamp, B., Vogogias, A., Preedy, K. F., & Milne, I. (2017). TetraploidSNPMap: Software for Linkage Analysis and QTL Mapping in Autotetraploid Populations Using SNP Dosage Data. Journal of Heredity, 108(4), 438-442. https://doi.org/10.1093/jhered/esx022

An earlier software application of ours, TetraploidMap for Windows, enabled linkage analysis and quantitative trait locus interval mapping to be carried out in an experimental cross of an autotetraploid species, using both dominant markers such as am... Read More about TetraploidSNPMap: Software for Linkage Analysis and QTL Mapping in Autotetraploid Populations Using SNP Dosage Data.