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Investigating the role of cell fate regulator ASCL1 in driving and maintaining lethal neuroendocrine castrate resistant prostate cancer (2022)
Presentation / Conference
Bruce, I., Pang, L., Poole, A., & Fraser, J. (2022, November). Investigating the role of cell fate regulator ASCL1 in driving and maintaining lethal neuroendocrine castrate resistant prostate cancer. Poster presented at Society for Endocrinology BES 2022, Harrogate

Neuroendocrine castrate resistant prostate cancer (NE-CRPC) is a lethal CRPC subtype that arises as prostate cancer cells transdifferentiate to neuroendocrine cells, evading the potent selective pressure of androgen deprivation therapies (ADT). Curre... Read More about Investigating the role of cell fate regulator ASCL1 in driving and maintaining lethal neuroendocrine castrate resistant prostate cancer.

De novo design of novel protease inhibitor candidates in the treatment of SARS-CoV-2 using deep learning, docking, and molecular dynamic simulations (2021)
Journal Article
Arshia, A. H., Shadravan, S., Solhjoo, A., Sakhteman, A., & Sami, A. (2021). De novo design of novel protease inhibitor candidates in the treatment of SARS-CoV-2 using deep learning, docking, and molecular dynamic simulations. Computers in Biology and Medicine, 139, Article 104967. https://doi.org/10.1016/j.compbiomed.2021.104967

The main protease of SARS-CoV-2 is a critical target for the design and development of antiviral drugs. 2.5 M compounds were used in this study to train an LSTM generative network via transfer learning in order to identify the four best candidates ca... Read More about De novo design of novel protease inhibitor candidates in the treatment of SARS-CoV-2 using deep learning, docking, and molecular dynamic simulations.

Hardware Design for Autonomous Robot Evolution (2020)
Conference Proceeding
Hale, M. F., Angus, M., Buchanan, E., Li, W., Woolley, R., Le Goff, L. K., …Tyrrell, A. M. (2020). Hardware Design for Autonomous Robot Evolution. In 2020 IEEE Symposium Series on Computational Intelligence (SSCI) (2140-2147). https://doi.org/10.1109/SSCI47803.2020.9308204

The long term goal of the Autonomous Robot Evolution (ARE) project is to create populations of physical robots, in which both the controllers and body plans are evolved. The transition for evolutionary designs from purely simulation environments into... Read More about Hardware Design for Autonomous Robot Evolution.

The effectiveness of cognitive-behavioural interventions at increasing adherence to physical activity in mental health populations: a systematic review (2019)
Journal Article
Snowden, A., Peddie, N., & Westbury, T. (2021). The effectiveness of cognitive-behavioural interventions at increasing adherence to physical activity in mental health populations: a systematic review. Advances in Mental Health, 19(1), 94-112. https://doi.org/10.1080/18387357.2019.1684829

Objective: There is growing global evidence for stark inequalities in the physical health status and life-expectancy of people with a mental health diagnosis. In most cases, physical activity (PA) is one of the most effective methods of maintaining p... Read More about The effectiveness of cognitive-behavioural interventions at increasing adherence to physical activity in mental health populations: a systematic review.

Health professionals' lack of knowledge of central venous access devices: the impact on patients (2019)
Journal Article
Kelly, L. J., Snowden, A., Paterson, R., & Campbell, K. (2019). Health professionals' lack of knowledge of central venous access devices: the impact on patients. British Journal of Nursing, 28(14), https://doi.org/10.12968/bjon.2019.28.14.S4

Background The literature on patient experience of living with a central venous access device (CVAD) is growing, but remains sparse. It suggests that patients accept CVADs as should reduce episodes of repeated cannulations. However, a recent doctor... Read More about Health professionals' lack of knowledge of central venous access devices: the impact on patients.

A review of the impact of utilising electronic medical records for clinical research recruitment (2019)
Journal Article
Lai, Y. S., & Afseth, J. D. (2019). A review of the impact of utilising electronic medical records for clinical research recruitment. Clinical Trials, 16(2), 194-203. https://doi.org/10.1177/1740774519829709

Introduction: Recruitment is an important aspect of clinical research, as poor recruitment could undermine the scientific value of a trial or delay the development process of new treatments. The development of electronic medical records provides a n... Read More about A review of the impact of utilising electronic medical records for clinical research recruitment.

Holistic needs assessment in brain cancer patients: A systematic review of available tools (2018)
Journal Article
Afseth, J., Neubeck, L., Karatzias, T., & Grant, R. (2019). Holistic needs assessment in brain cancer patients: A systematic review of available tools. European Journal of Cancer Care, 28(3), Article e12931. https://doi.org/10.1111/ecc.12931

This systematic review describes tools which could be considered for use for holistic needs assessment in Brain Cancer. MEDLINE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and PsycINFO were searched. Studies where included wh... Read More about Holistic needs assessment in brain cancer patients: A systematic review of available tools.

Proactive community support tailored to holistic needs: A cohort study (2018)
Journal Article
Snowden, A., Young, J., & Savinc, J. (2018). Proactive community support tailored to holistic needs: A cohort study. Cancer Medicine, 7(9), 4836-4845. https://doi.org/10.1002/cam4.1709

Background: It is increasingly internationally recognised that a cancer diagnosis impacts on people practically and financially as well as physically and psychologically. It is less clear what to do about this. This study introduces an original com... Read More about Proactive community support tailored to holistic needs: A cohort study.

Exploring male identity in non-professional carers of someone with cancer: preliminary analysis (2018)
Presentation / Conference
Young, J., Snowden, A., Stenhouse, R., & Kyle, R. (2018, March). Exploring male identity in non-professional carers of someone with cancer: preliminary analysis. Poster presented at British Psych-Oncology Society Annual Conference

Background Across the world the majority of home‐based care for ill family members is carried out by women. Consequently, research in this field has predominately focused on female carers, meaning less is known about the male carer experience. My s... Read More about Exploring male identity in non-professional carers of someone with cancer: preliminary analysis.

The role of social context in symptom appraisal and help-seeking among people with lung or colorectal symptoms: A qualitative interview study (2018)
Journal Article
Dobson, C., Russell, A., Brown, S., & Rubin, G. (2018). The role of social context in symptom appraisal and help-seeking among people with lung or colorectal symptoms: A qualitative interview study. European Journal of Cancer Care, 27(2), Article e12815. https://doi.org/10.1111/ecc.12815

Prolonged diagnostic intervals are associated with poorer outcomes, and the patient interval appears to be a substantial contributor to the overall length of the diagnostic interval. This study sought to understand how the broader context of people's... Read More about The role of social context in symptom appraisal and help-seeking among people with lung or colorectal symptoms: A qualitative interview study.

Widening Access; Developing an eLearning Resource for Health and Social Care Professionals Caring for Children and Young People with Cancer (2017)
Journal Article
McInally, W., Pouso Lista, M. J., McLaren, N., & Willis, D. S. (2017). Widening Access; Developing an eLearning Resource for Health and Social Care Professionals Caring for Children and Young People with Cancer. Journal of Cancer Education, https://doi.org/10.1007/s13187-017-1284-6

Cancer is a key priority worldwide, and caring for children and young people with cancer requires a range of specific knowledge, skills and experience in order to deliver the complex care regimes both within the hospital or community environment. The... Read More about Widening Access; Developing an eLearning Resource for Health and Social Care Professionals Caring for Children and Young People with Cancer.

Holistic Needs Assessment in Brain Cancer Patients: A Systematic Review of Available Tools (2017)
Presentation / Conference
Afseth, J., Neubeck, L., Karatzias, T., & Grant, R. (2017, June). Holistic Needs Assessment in Brain Cancer Patients: A Systematic Review of Available Tools. Poster presented at British Neuro Oncology Conference

BACKGROUND: A diagnosis of brain cancer affects nearly 10 000 adults per year in the United Kingdom and has a devastating impact. This is due to the poor prognosis as well as a significant symptom burden, which often includes neurocognitive deficits.... Read More about Holistic Needs Assessment in Brain Cancer Patients: A Systematic Review of Available Tools.

Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells (2016)
Conference Proceeding
Sutton, J., Hutchison, G., Fraser, J., & Poole, A. (2016). Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells

Background: Neuroendocrine differentiation is commonplace in prostate tumors treated with androgen deprivation therapy and is associated with castrate-resistant disease progression and poor prognosis. The molecular mechanisms driving neuroendocrine d... Read More about Investigating the molecular mechanisms driving neuroendocrine differentiation in androgen deprived prostate cancer cells.

Evaluation of Improving Cancer Journeys (2016)
Report
Snowden, A., & Young, J. (2016). Evaluation of Improving Cancer Journeys. Glasgow: Macmillan Cancer Support UK

First report of five year evaluation.

In vivo in uterus non-invasive methods to predict placental insufficiency and adverse pregnancy outcomes in antiphospholipid syndrome (2014)
Conference Proceeding
Girardi, G., Fraser, J., Bertolaccini, M. L., Lennen, R., Vontell, R., & Hutchison, G. (2014). In vivo in uterus non-invasive methods to predict placental insufficiency and adverse pregnancy outcomes in antiphospholipid syndrome. https://doi.org/10.1016/j.placenta.2014.06.184

Objectives: To use MRI-based methods to non invasively detect placental insufficiency and predict fetal outcomes in obstetric antiphospholipid syndrome (APS) Methods and result: A) Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles conjug... Read More about In vivo in uterus non-invasive methods to predict placental insufficiency and adverse pregnancy outcomes in antiphospholipid syndrome.

Genetics Healthcare & Public Health Screening in Scotland (2012)
Report
Kerr, G. (2012). Genetics Healthcare & Public Health Screening in Scotland. The Scottish Parliament: The Scottish Parliament

This briefing describes genetic healthcare services and public health screening programmes in Scotland. It includes a brief introduction to genetics in relation to healthcare; information on the four regional genetics services and an overview of rece... Read More about Genetics Healthcare & Public Health Screening in Scotland.

Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomised controlled trial (2007)
Journal Article
Mutrie, N., Campbell, A. M., Whyte, F., McConnachie, A., Emslie, C., Lee, L., …Ritchie, D. (2007). Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomised controlled trial. BMJ, 334(7592), 517. https://doi.org/10.1136/bmj.39094.648553.ae

Objectives To determine functional and psychological benefits of a 12 week supervised group exercise programme during treatment for early stage breast cancer, with six month follow-up.Design Pragmatic randomised controlled prospective open trial.Sett... Read More about Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomised controlled trial.