Problems and solutions: Accounts by parents and children of adhering to chest physiotherapy for cystic fibrosis (2007)
Journal Article
Williams, B., Mukhopadhyay, S., Dowell, J., & Coyle, J. (2007). Problems and solutions: Accounts by parents and children of adhering to chest physiotherapy for cystic fibrosis. Disability and Rehabilitation, 29(14), 1097-1105

Although chest physiotherapy is central to the management of cystic fibrosis (CF), adherence among children is problematic. This study explores accounts by parents and children of the difficulties of adhering to chest physiotherapy for cystic fibrosi... Read More about Problems and solutions: Accounts by parents and children of adhering to chest physiotherapy for cystic fibrosis.

P214 NMDA receptor signalling in human osteoarthritic chondrocytes. (2007)
Presentation / Conference Contribution
Ramage, L., Hardingham, G., & Salter, D. (2007, September). P214 NMDA receptor signalling in human osteoarthritic chondrocytes. Presented at ICRS 2007, Warsaw, Poland

Purpose: Human OA chondrocytes are known to express several subunits of the NMDA receptor (NMDAR), a neuronal signalling molecule. This study analyses downstream activation events and interactions of NMDAR with molecules known to be involved in chond... Read More about P214 NMDA receptor signalling in human osteoarthritic chondrocytes..

Expression of Cannabinoid CB1 receptors in models of diabetic neuropathy (2007)
Journal Article
Zhang, F., Hong, S., Stone, V., & Smith, P. (2007). Expression of Cannabinoid CB1 receptors in models of diabetic neuropathy. Journal of Pharmacology and Experimental Therapeutics, 323, 508-515. https://doi.org/10.1124/jpet.107.128272

A clearer understanding of the mechanisms underlying the development and progression of diabetic neuropathy is likely to indicate new directions for the treatment of this complication of diabetes. In the present study we investigated the expression o... Read More about Expression of Cannabinoid CB1 receptors in models of diabetic neuropathy.

Sertoli Cell Development and Function in an Animal Model of Testicular Dysgenesis Syndrome1 (2007)
Journal Article
Hutchison, G. R., Scott, H. M., Walker, M., McKinnell, C., Ferrara, D., Mahood, I. K., & Sharpe, R. M. (2008). Sertoli Cell Development and Function in an Animal Model of Testicular Dysgenesis Syndrome1. Biology of Reproduction, 78(2), 352-360. https://doi.org/10.1095/biolreprod.107.064006

Pregnancy exposure to di(n-butyl) phthalate (DBP) in rats induces a testicular dysgenesislike syndrome (TDS) in male offspring. Earlier studies suggested altered Sertoli cell development/maturation may result, especially in testes that become cryptor... Read More about Sertoli Cell Development and Function in an Animal Model of Testicular Dysgenesis Syndrome1.

The origins and time of appearance of focal testicular dysgenesis in an animal model of testicular dysgenesis syndrome: evidence for delayed testis development? (2007)
Journal Article
Hutchison, G. R., Sharpe, R. M., Mahood, I. K., Jobling, M., Walker, M., McKinnell, C., Mason, J. I., & Scott, H. M. (2008). The origins and time of appearance of focal testicular dysgenesis in an animal model of testicular dysgenesis syndrome: evidence for delayed testis development?. International Journal of Andrology, 31(2), 103-111. https://doi.org/10.1111/j.1365-2605.2007.00816.x

A testicular dysgenesis-like syndrome is induced in rats by fetal exposure todi(n-butyl) phthalate (DBP). A key feature of this is the formation of focal dys-genetic areas comprising malformed seminiferous cords⁄tubules and intratubu-lar Leydig cells... Read More about The origins and time of appearance of focal testicular dysgenesis in an animal model of testicular dysgenesis syndrome: evidence for delayed testis development?.

Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure (2007)
Journal Article
Barlow, P. G., Brown, D. M., Donaldson, K., MacCallum, J., & Stone, V. (2008). Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure. Cell Biology and Toxicology, 24(3), 243-252. https://doi.org/10.1007/s10565-007-9033-y

Increased levels of particulate air pollution (PM10) have been implicated as a causal agent in pulmonary disease exacerbation and increased deaths from respiratory and cardiovascular disorders. The exact mechanism by which PM10 drives toxicity in the... Read More about Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure.

Role of Androgens in Fetal Testis Development and Dysgenesis (2007)
Journal Article
Scott, H. M., Hutchison, G. R., Mahood, I. K., Hallmark, N., Welsh, M., De Gendt, K., Verhoeven, G., O’Shaughnessy, P., & Sharpe, R. M. (2007). Role of Androgens in Fetal Testis Development and Dysgenesis. Endocrinology, 148(5), 2027-2036. https://doi.org/10.1210/en.2006-1622

This study sought to establish whether reduced androgen levels/action in the fetal rat testis induced by di(n-butyl) phthalate (DBP) contributes to dysgenetic features, namely reduced Sertoli cell number, occurrence of multinucleated gonocytes (MNG),... Read More about Role of Androgens in Fetal Testis Development and Dysgenesis.

P186 Expression of functional NMDA receptors in human OA chondrocytes (2007)
Presentation / Conference Contribution
Ramage, L., Martel, M.-A., Hardingham, G., & Salter, D. (2006, December). P186 Expression of functional NMDA receptors in human OA chondrocytes. Presented at 2006 World Congress on Osteoarthritis, Prague, Czechia

Purpose: Classical neuronal signalling molecules such as substance P and glutamate have been identified in cartilage and are being shown to have roles in regulation of chondrocyte function. This study looks at the expression and function of the metab... Read More about P186 Expression of functional NMDA receptors in human OA chondrocytes.