Prof Gary Hutchison Ga.Hutchison@napier.ac.uk
Dean of Applied Sciences
Prof Gary Hutchison Ga.Hutchison@napier.ac.uk
Dean of Applied Sciences
Richard M. Sharpe
I. Kim Mahood
Matt Jobling
Marion Walker
Chris McKinnell
J. Ian Mason
Hayley M. Scott
A testicular dysgenesis-like syndrome is induced in rats by fetal exposure todi(n-butyl) phthalate (DBP). A key feature of this is the formation of focal dys-genetic areas comprising malformed seminiferous cords⁄tubules and intratubu-lar Leydig cells (ITLC), but how and why these arise remains unclear. Thepresent study has used combinations of cell-specific markers and immunohisto-chemistry to address this. The results show that focal dysgenetic areas andITLC first appear postnatally at 4–10 days of age, but this only occurs in treat-ment groups in which formation of fetal Leydig cell aggregation is inducedbetween e17.5 and e21.5. Extreme variability in the formation and size of theLeydig cell aggregates probably accounts for the equally extreme variation inoccurrence and size of focal dysgenetic areas postnatally. DBP-induced fetalLeydig cell aggregation traps Sertoli and other cells within the aggregates, but itis unclear why this happens nor why cords fail to form prenatally in these cellmixtures but do elsewhere in the fetal testis. The present studies show that dif-ferentiation of the fetal Leydig cells is drastically delayed at e15.5 after DBPexposure, which may be indicative of a wider delay in testis cell developmentand organisation, and this might account for some of the unexplained findings.
Hutchison, G. R., Sharpe, R. M., Mahood, I. K., Jobling, M., Walker, M., McKinnell, C., Mason, J. I., & Scott, H. M. (2008). The origins and time of appearance of focal testicular dysgenesis in an animal model of testicular dysgenesis syndrome: evidence for delayed testis development?. International Journal of Andrology, 31(2), 103-111. https://doi.org/10.1111/j.1365-2605.2007.00816.x
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 9, 2007 |
Online Publication Date | Sep 18, 2007 |
Publication Date | 2008-04 |
Deposit Date | May 1, 2019 |
Journal | International Journal of Andrology |
Print ISSN | 0105-6263 |
Electronic ISSN | 1365-2605 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 31 |
Issue | 2 |
Pages | 103-111 |
DOI | https://doi.org/10.1111/j.1365-2605.2007.00816.x |
Keywords | di(n-butyl) phthalate, dysgenetic areas, fetalLeydig cell aggregation, fetal testis, intratublarLeydig cells, seminiferous cords, Sertoli cells |
Public URL | http://researchrepository.napier.ac.uk/Output/1749640 |
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