The effect of azathioprine on bone health (2019)
Thesis
Morgan, S. The effect of azathioprine on bone health. (Thesis). Edinburgh Napier University. http://researchrepository.napier.ac.uk/Output/2386593

Individuals with inflammatory bowel disease (IBD) often present with poor bone health and have increased risk of osteoporotic bone fractures. The development of targeted therapies for this bone loss requires a better understanding of the underlying c... Read More about The effect of azathioprine on bone health.

Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing an improved testing strategy for hazard assessment (2019)
Thesis
Ross, B. L. Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing an improved testing strategy for hazard assessment. (Thesis). Edinburgh Napier University. http://researchrepository.napier.ac.uk/Output/2404236

Reproduction is the only certain constant within animals and maintaining the integrity of this process is key to ensuring survival of the species. However, male fertility rates in the Western world are in decline and the use of assisted reproductive... Read More about Assessing the toxicity of engineered nanomaterials in the male reproductive system: Developing an improved testing strategy for hazard assessment.

Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis (2019)
Journal Article
Staines, K., Ikpegbu, E., Törnqvist, A., Dillon, S., Javaheri, B., Amin, A. K., Clements, D. N., Buttle, D. J., Pitsillides, A. A., & Farquharson, C. (2019). Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis. BMC Musculoskeletal Disorders, 20, Article 344 (2019). https://doi.org/10.1186/s12891-019-2731-9

Background: Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether disruption... Read More about Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis.

The Effects of Inflammatory Bowel Disease Drugs on the Autophagy Pathway (2019)
Thesis
Hooper, K. The Effects of Inflammatory Bowel Disease Drugs on the Autophagy Pathway. (Thesis). Edinburgh Napier University. http://researchrepository.napier.ac.uk/Output/2070992

Crohn’s disease (CD), one of the main forms of Inflammatory Bowel Disease (IBD), is a complex disorder characterised by chronic inflammation of the gastrointestinal (GI) tract. The aetiology of CD involves genetics and environmental factors that trig... Read More about The Effects of Inflammatory Bowel Disease Drugs on the Autophagy Pathway.

The role of the human cathelicidin LL-37 in rhinovirus infection (2019)
Thesis
Henderson Sousa, F. The role of the human cathelicidin LL-37 in rhinovirus infection. (Thesis). Edinburgh Napier University. http://researchrepository.napier.ac.uk/Output/2070903

Human rhinoviruses (HRVs) are the most common causes for symptomatic respiratory infections, and have been linked to severe respiratory conditions in children, and in immunocompromised and elderly individuals. Currently there are no specific treatmen... Read More about The role of the human cathelicidin LL-37 in rhinovirus infection.

The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK (2019)
Journal Article
Hooper, K. M., Casanova, V., Kemp, S., Staines, K. A., Satsangi, J., Barlow, P. G., Henderson, P., & Stevens, C. (2019). The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK. Inflammatory Bowel Diseases, 25(9), 1481-1496. https://doi.org/10.1093/ibd/izz039

Background Genetic studies have strongly linked autophagy to Crohn's disease (CD) and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this study was to evaluate the effect of current inflammatory bowel disease (IBD)... Read More about The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK.

Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease (2018)
Journal Article
Hooper, K. M., Barlow, P. G., Henderson, P., & Stevens, C. (2019). Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 25(4), 661-671. https://doi.org/10.1093/ibd/izy380

Inflammatory Bowel Disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis, is characterised by chronic inflammation of the gastrointestinal tract. Aetiology involves a combination of genetic and environmental factors resulting in a... Read More about Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease.

The role of exercise in cancer rehabilation. (2018)
Presentation / Conference Contribution
Campbell, A. (2018, April). The role of exercise in cancer rehabilation. Presented at Danish Physiotherapy Conference

No abstract available.

The role of social context in symptom appraisal and help-seeking among people with lung or colorectal symptoms: A qualitative interview study (2018)
Journal Article
Dobson, C., Russell, A., Brown, S., & Rubin, G. (2018). The role of social context in symptom appraisal and help-seeking among people with lung or colorectal symptoms: A qualitative interview study. European Journal of Cancer Care, 27(2), Article e12815. https://doi.org/10.1111/ecc.12815

Prolonged diagnostic intervals are associated with poorer outcomes, and the patient interval appears to be a substantial contributor to the overall length of the diagnostic interval. This study sought to understand how the broader context of people's... Read More about The role of social context in symptom appraisal and help-seeking among people with lung or colorectal symptoms: A qualitative interview study.

Control of Antimicrobial Resistance Requires an Ethical Approach (2017)
Journal Article
Parsonage, B., Hagglund, P. K., Keogh, L., Wheelhouse, N., Brown, R. E., & Dancer, S. J. (2017). Control of Antimicrobial Resistance Requires an Ethical Approach. Frontiers in Microbiology, 8, https://doi.org/10.3389/fmicb.2017.02124

Ethical behavior encompasses actions that benefit both self and society. This means that tackling antimicrobial resistance (AMR) becomes an ethical obligation, because the prospect of declining anti-infectives affects everyone. Without preventive act... Read More about Control of Antimicrobial Resistance Requires an Ethical Approach.

Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia (2017)
Journal Article
Martín-Aragón Baudel, M. A. S., Rae, M. T., Darlison, M. G., Poole, A. V., & Fraser, J. A. (2017). Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia. PLOS ONE, 12(10), Article e0185664. https://doi.org/10.1371/journal.pone.0185664

Stroke causes severe neuronal damage as disrupted cerebral blood flow starves neurons of oxygen and glucose. The hypoxia inducible factors (HIF-1α and HIF-2α) orchestrate oxygen homeostasis and regulate specific aspects of hypoxic adaptation. Here we... Read More about Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia.

Inflammatory Bowel Disease Drugs: A Focus on Autophagy (2016)
Journal Article
Hooper, K. M., Barlow, P. G., Stevens, C., & Henderson, P. (2017). Inflammatory Bowel Disease Drugs: A Focus on Autophagy. Journal of Crohn's and Colitis, 11(1), 118-127. https://doi.org/10.1093/ecco-jcc/jjw127

Inflammatory bowel disease [IBD] is characterized by chronic inflammation of the gastrointestinal tract. Medications such as corticosteroids, thiopurines, immunomodulators and biologic agents are used to induce and maintain remission; however, respon... Read More about Inflammatory Bowel Disease Drugs: A Focus on Autophagy.

Health value & perceived control over health: behavioural constructs to support Type 2 diabetes self-management in clinical practice (2015)
Journal Article
Nugent, L. E., Carson, M., Zammitt, N. N., Smith, G. D., & Wallston, K. A. (2015). Health value & perceived control over health: behavioural constructs to support Type 2 diabetes self-management in clinical practice. Journal of Clinical Nursing, 24(15-16), 2201-2210. https://doi.org/10.1111/jocn.12878

Aims and objectives

To explore health value and perceived control over health in relation to self-management behaviours in adults with Type 2 diabetes mellitus.
Background

Helping people to modify health related behaviour in diabetes is comple... Read More about Health value & perceived control over health: behavioural constructs to support Type 2 diabetes self-management in clinical practice.

Effects of etidronate on the Enpp1−/− mouse model of generalized arterial calcification of infancy (2015)
Journal Article
Huesa, C., Staines, K. A., Millán, J. L., & MacRae, V. E. (2015). Effects of etidronate on the Enpp1−/− mouse model of generalized arterial calcification of infancy. International Journal of Molecular Medicine, 36(1), 159-165. https://doi.org/10.3892/ijmm.2015.2212

Generalized arterial calcification of infancy (GACI) is an autosomal recessive disorder of spontaneous infantile arterial and periarticular calcification which is attributed to mutations in the ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp... Read More about Effects of etidronate on the Enpp1−/− mouse model of generalized arterial calcification of infancy.

PWE-090 the effect of commonly used Ibd drugs on autophagy induction using an in vitro cell culture system. (2014)
Journal Article
Henderson, P., Satsangi, J., Wilson, D., & Stevens, C. (2014). PWE-090 the effect of commonly used Ibd drugs on autophagy induction using an in vitro cell culture system. Gut, 63(Suppl 1), A163. https://doi.org/10.1136/gutjnl-2014-307263.350

Introduction Genome wide association studies and functional experiments in inflammatory bowel disease (IBD) have delineated the importance of autophagy in IBD pathogenesis. We aimed to determine the effect of commonly utilised IBD drugs on autophagy... Read More about PWE-090 the effect of commonly used Ibd drugs on autophagy induction using an in vitro cell culture system..

Subclinical diastolic dysfunction in young adults with Type 2 diabetes mellitus: a multiparametric contrast-enhanced cardiovascular magnetic resonance pilot study assessing potential mechanisms (2014)
Journal Article
Khan, J. N., Wilmot, E. G., Leggate, M., Singh, A., Yates, T., Nimmo, M., Khunti, K., Horsfield, M. A., Biglands, J., Clarysse, P., Croisille, P., Davies, M., & McCann, G. P. (2014). Subclinical diastolic dysfunction in young adults with Type 2 diabetes mellitus: a multiparametric contrast-enhanced cardiovascular magnetic resonance pilot study assessing potential mechanisms. European heart journal cardiovascular Imaging, 15(11), 1263-1269. https://doi.org/10.1093/ehjci/jeu121

Aims To assess the cardiac, vascular, anthropometric, and biochemical determinants of subclinical diastolic dysfunction in younger adults with Type 2 diabetes mellitus (T2DM) using multiparametric contrast-enhanced cardiovascular magnetic resonance... Read More about Subclinical diastolic dysfunction in young adults with Type 2 diabetes mellitus: a multiparametric contrast-enhanced cardiovascular magnetic resonance pilot study assessing potential mechanisms.

Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction (2014)
Journal Article
Wilmot, E. G., Leggate, M., Khan, J. N., Yates, T., Gorely, T., Bodicoat, D. H., Khunti, K., Kuijer, J. P. A., Gray, L. J., Singh, A., Clarysse, P., Croisille, P., Nimmo, M. A., McCann, G. P., & Davies, M. J. (2014). Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction. Diabetic medicine : a journal of the British Diabetic Association, 31(7), 794-798. https://doi.org/10.1111/dme.12431

Aim

A pilot study to phenotype young adults (< 40 years) with Type 2 diabetes mellitus.
Methods

Twenty people with Type 2 diabetes (aged 18–40 years), 10 lean and 10 obese control subjects underwent detailed assessment, including tagged cardia... Read More about Type 2 diabetes mellitus and obesity in young adults: the extreme phenotype with early cardiovascular dysfunction.

Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling (2013)
Journal Article
Staines, K. A., Zhu, D., Farquharson, C., & MacRae, V. E. (2014). Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling. Journal of Bone and Mineral Metabolism, 32(3), 240-251. https://doi.org/10.1007/s00774-013-0493-2

Bone mineralization is a carefully orchestrated process, regulated by a number of promoters and inhibitors that function to ensure effective hydroxyapatite formation. Here we sought to identify new regulators of this process through a time series mic... Read More about Identification of novel regulators of osteoblast matrix mineralization by time series transcriptional profiling.

Chondrogenic ATDC5 cells: An optimised model for rapid and physiological matrix mineralisation (2012)
Journal Article
Newton, P. T., Staines, K. A., Spevak, L., Boskey, A. L., Teixeira, C. C., Macrae, V. E., Canfield, A. E., & Farquharson, C. (2012). Chondrogenic ATDC5 cells: An optimised model for rapid and physiological matrix mineralisation. International Journal of Molecular Medicine, 30(5), 1187-1193. https://doi.org/10.3892/ijmm.2012.1114

The development of chondrogenic cell lines has led to major advances in the understanding of how chondrocyte differentiation is regulated, and has uncovered many signalling pathways and gene regulatory mechanisms required to maintain normal function.... Read More about Chondrogenic ATDC5 cells: An optimised model for rapid and physiological matrix mineralisation.

A role for vimentin in Crohn disease (2012)
Journal Article
Henderson, P., Wilson, D. C., Satsangi, J., & Stevens, C. (2012). A role for vimentin in Crohn disease. Autophagy, 8(11), 1695-1696. https://doi.org/10.4161/auto.21690

Crohn disease (CD), one of the major chronic inflammatory bowel diseases, occurs anywhere in the gastrointestinal tract with discontinuous transmural inflammation. A number of studies have now demonstrated that genetic predisposition, environmental... Read More about A role for vimentin in Crohn disease.