E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models (2015)
Journal Article
Staines, K. A., Prideaux, M., Allen, S., Buttle, D. J., Pitsillides, A. A., & Farquharson, C. (2016). E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models. Journal of Cellular Physiology, 231(6), 1392-1404. https://doi.org/10.1002/jcp.25282

The transmembrane glycoprotein E11 is considered critical in early osteoblast–osteocyte transitions (osteocytogenesis), however its function and regulatory mechanisms are still unknown. Using the late osteoblast MLO-A5 cell line we reveal increased E... Read More about E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models.

Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing (2015)
Journal Article
Zaman, G., Farquharson, C., Staines, K. A., Newton, P. T., Dudhia, J., Chenu, C., Pitsillides, A. A., & Dhoot, G. K. (2016). Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing. Histochemistry and Cell Biology, 145(1), 67-79. https://doi.org/10.1007/s00418-015-1365-8

SULF1/SULF2 enzymes regulate cell signalling that impacts the growth and differentiation of many tissues. To determine their possible role in cartilage and bone growth or repair, their expression was examined during development and bone fracture heal... Read More about Expression of Sulf1 and Sulf2 in cartilage, bone and endochondral fracture healing.

Constructing more informative plant–pollinator networks: visitation and pollen deposition networks in a heathland plant community (2015)
Journal Article
Ballantyne, G., Baldock, K. C. R., & Willmer, P. G. (2015). Constructing more informative plant–pollinator networks: visitation and pollen deposition networks in a heathland plant community. Proceedings of the Royal Society B: Biological Sciences, 282(1814), Article 20151130. https://doi.org/10.1098/rspb.2015.1130

Interaction networks are widely used as tools to understand plant–pollinator communities, and to examine potential threats to plant diversity and food security if the ecosystem service provided by pollinating animals declines. However, most networks... Read More about Constructing more informative plant–pollinator networks: visitation and pollen deposition networks in a heathland plant community.

Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing (2015)
Journal Article
Javaheri, B., Carriero, A., Staines, K. A., Chang, Y.-M., Houston, D. A., Oldknow, K. J., Millan, J. L., Kazeruni, B. N., Salmon, P., Shefelbine, S., Farquharson, C., & Pitsillides, A. A. (2015). Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing. Bone, 81, 277-291. https://doi.org/10.1016/j.bone.2015.07.035

PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice (Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, bowed long bones, osteomalaci... Read More about Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing.

Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart (2015)
Journal Article
Wilson, K. S., Baily, J., Tucker, C. S., Matrone, G., Vass, S., Moran, C., Chapman, K. E., Mullins, J. J., Kenyon, C., Hadoke, P. W. F., & Denvir, M. A. (2015). Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart. Molecular and Cellular Endocrinology, 414, 120-131. https://doi.org/10.1016/j.mce.2015.07.025

Background

Transient early-life perturbations in glucocorticoids (GC) are linked with cardiovascular disease risk in later life. Here the impact of early life manipulations of GC on adult heart structure, function and gene expression were assessed... Read More about Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart.

Impact of Glucocorticoid Induced Reprogramming on Functional, Histological and Molecular Signalling in the Adult Zebrafish Heart (2015)
Presentation / Conference Contribution
Wilson, K., Baily, J., Tucker, C., Vass, S., Moran, C., Chapman, K., Mullins, J., Kenyon, C., Hadoke, P., & Denvir, M. Impact of Glucocorticoid Induced Reprogramming on Functional, Histological and Molecular Signalling in the Adult Zebrafish Heart

Introduction Foetal over-exposure to glucocorticoids (GC) has been associated with cardiovascular disorder in later life however the impact of transient early life alterations in GC activity on the heart itself has not been widely studied. We explore... Read More about Impact of Glucocorticoid Induced Reprogramming on Functional, Histological and Molecular Signalling in the Adult Zebrafish Heart.

The influence of age and cardiorespiratory fitness on circulating angiogenic T cells and CXCR4 expression. (2015)
Presentation / Conference Contribution
Ross, M. D., Malone, E. M., Simpson, R. J., & Florida-James, G. (2015, May). The influence of age and cardiorespiratory fitness on circulating angiogenic T cells and CXCR4 expression. Presented at Annual Congress of the American College of Sports Medicine (ACSM)

Aging is associated with endothelial dysfunction, reduced angiogenic capabilities, and an increase in arterial stiffness. Additionally, regular exercise is known to offset the age-related decline in blood vessel number and function. Circulating angio... Read More about The influence of age and cardiorespiratory fitness on circulating angiogenic T cells and CXCR4 expression..

MMP and TIMP temporal gene expression during osteocytogenesis (2015)
Journal Article
Prideaux, M., Staines, K. A., Jones, E. R., Riley, G. P., Pitsillides, A. A., & Farquharson, C. (2015). MMP and TIMP temporal gene expression during osteocytogenesis. Gene Expression Patterns, 18(1-2), 29-36. https://doi.org/10.1016/j.gep.2015.04.004

Osteocytes within bone differentiate from osteoblast precursors which reside in a mineralised extracellular matrix (ECM). Fully differentiated osteocytes are critical for bone development and function but the factors that regulate this differentiatio... Read More about MMP and TIMP temporal gene expression during osteocytogenesis.

Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1: SOCS2 REGULATION OF GH INDUCED GROWTH (2015)
Journal Article
Dobie, R., Ahmed, S. F., Staines, K. A., Pass, C., Jasim, S., MacRae, V. E., & Farquharson, C. (2015). Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1: SOCS2 REGULATION OF GH INDUCED GROWTH. Journal of Cellular Physiology, 230(11), 2796-2806. https://doi.org/10.1002/jcp.25006

Growth hormone (GH) signaling is essential for postnatal linear bone growth, but the relative importance of GHs actions on the liver and/or growth plate cartilage remains unclear. The importance of liver derived insulin like-growth factor-1 (IGF-1) f... Read More about Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1: SOCS2 REGULATION OF GH INDUCED GROWTH.