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Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion (2021)
Journal Article
Livingstone, M., Ranjan Wattegedera, S., Palarea-Albaladejo, J., Aitchison, K., Corbett, C., Sait, M., …Longbottom, D. (2021). Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion. Vaccines, 9(8), https://doi.org/10.3390/vaccines9080898

Chlamydia abortus, the aetiological agent of enzootic abortion of ewes, is a major cause of reproductive loss in small ruminants worldwide, accounting for significant economic losses to the farming industry. Disease can be managed through the use of... Read More about Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion.

A paradigm shift to combat indoor respiratory infection (2021)
Journal Article
Morawska, L., Allen, J., Bahnfleth, W., Bluyssen, P. M., Boerstra, A., Buonanno, G., …Yao, M. (2021). A paradigm shift to combat indoor respiratory infection. Science, 372(6543), 689-691. https://doi.org/10.1126/science.abg2025

There is great disparity in the way we think about and address different sources of environmental infection. Governments have for decades promulgated a large amount of legislation and invested heavily in food safety, sanitation, and drinking water fo... Read More about A paradigm shift to combat indoor respiratory infection.

Can we do better? A guide to pandemics – some Dos and Don'ts for the next one (2021)
Journal Article
Tang, J. W., Kwok, K. O., Loh, T. P., Lee, C. K., Heraud, J., & Dancer, S. J. (2021). Can we do better? A guide to pandemics – some Dos and Don'ts for the next one. Journal of Infection, 83(1), 119-145. https://doi.org/10.1016/j.jinf.2021.04.017

Specific features of any rapidly spread pathogen needs early recognition and assessment for possible pandemic potential. These include: inter-person transmissibility and exponential spread, which results in significant morbidity, mortality. These a... Read More about Can we do better? A guide to pandemics – some Dos and Don'ts for the next one.

How dirty is your QWERTY? The risk of healthcare pathogen transmission from computer keyboards (2021)
Journal Article
Ledwoch, K., Dancer, S., Otter, J., Kerr, K., Roposte, D., & Maillard, J. (2021). How dirty is your QWERTY? The risk of healthcare pathogen transmission from computer keyboards. Journal of Hospital Infection, 112, 31-36. https://doi.org/10.1016/j.jhin.2021.02.021

Introduction Healthcare environmental surfaces may be contaminated with micro-organisms that cause healthcare-associated infections (HCAIs). Special attention is paid to near-patient surfaces but sites outside the patient zone receive less attention... Read More about How dirty is your QWERTY? The risk of healthcare pathogen transmission from computer keyboards.

A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants (2020)
Journal Article
Marano, R. B., Fernandes, T., Manaia, C. M., Nunes, O., Morrison, D., Berendonk, T. U., …Cytryn, E. (2020). A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants. Environment International, 144, https://doi.org/10.1016/j.envint.2020.106035

The World Health Organization Global Action Plan recommends integrated surveillance programs as crucial strategies for monitoring antibiotic resistance. Although several national surveillance programs are in place for clinical and veterinary settings... Read More about A global multinational survey of cefotaxime-resistant coliforms in urban wastewater treatment plants.

Bacterial Transfer To Fingertips During Sequential Surface Contacts With And Without Gloves (2020)
Journal Article
King, M., López‐García, M., Atedoghu, K. P., Zhang, N., Wilson, A. M., Weterings, M., …Fletcher, L. A. (2020). Bacterial Transfer To Fingertips During Sequential Surface Contacts With And Without Gloves. Indoor Air, 30(5), 993-1004. https://doi.org/10.1111/ina.12682

Bacterial transmission from contaminated surfaces via hand contact plays a critical role in disease spread. However, the fomite‐to‐finger transfer efficiency of microorganisms during multiple sequential surface contacts with and without gloves has no... Read More about Bacterial Transfer To Fingertips During Sequential Surface Contacts With And Without Gloves.

Dynamic Transmission of Staphylococcus Aureus in the Intensive Care Unit (2020)
Journal Article
Adams, C. E., & Dancer, S. J. (2020). Dynamic Transmission of Staphylococcus Aureus in the Intensive Care Unit. International Journal of Environmental Research and Public Health, 17(6), https://doi.org/10.3390/ijerph17062109

Staphylococcus aureus is an important bacterial pathogen. This study utilized known staphylococcal epidemiology to track S. aureus between patients, surfaces, staff hands and air in a ten-bed intensive care unit (ICU). Methods: Patients, air and surf... Read More about Dynamic Transmission of Staphylococcus Aureus in the Intensive Care Unit.

Measuring environmental contamination in critical care using dilute hydrogen peroxide (DHP) technology: An observational cross-over study (2020)
Journal Article
Oon, A., Reading, E., Ferguson, J., Dancer, S., & Mitchell, B. (2020). Measuring environmental contamination in critical care using dilute hydrogen peroxide (DHP) technology: An observational cross-over study. Infection, Disease & Health, 25(2), 107-112. https://doi.org/10.1016/j.idh.2019.12.005

Background The environment has an important role in the transmission of healthcare associated infections. This has encouraged interest in novel methods to improve hygiene in hospitals. One such technology is the use of hydrogen peroxide to decontami... Read More about Measuring environmental contamination in critical care using dilute hydrogen peroxide (DHP) technology: An observational cross-over study.

Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo (2019)
Journal Article
Mathur, S., Turnbull, A., Akaev, I., Stevens, C., Agrawal, N., Chopra, M., & Mincher, D. (2020). Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo. International Journal of Peptide Research and Therapeutics, 26, 1965-1980. https://doi.org/10.1007/s10989-019-09994-1

The lysosomal endoprotease legumain (asparaginyl endoprotease) has been proposed as a putative biomarker in prostate tumours, in which the enzyme is markedly overexpressed. Overexpression, coupled with highly selective specificity for cleavage of sub... Read More about Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo.

Hand antisepsis without decreasing efficacy by shortening the rub-in time of alcohol-based handrubs to 15 seconds (2019)
Journal Article
Harnoss, J., Dancer, S., Kaden, C., Baguhl, R., Kohlmann, T., Papke, R., …Kramer, A. (2020). Hand antisepsis without decreasing efficacy by shortening the rub-in time of alcohol-based handrubs to 15 seconds. Journal of Hospital Infection, 104(4), 419-424. https://doi.org/10.1016/j.jhin.2019.09.004

Background A previous study among neonatal intensive care unit (NICU) nurses showed that the antibacterial efficacy of alcohol-based handrubs (ABHR) can be achieved in 15 s instead of 30 s with a significant increase in the frequency of hand antisep... Read More about Hand antisepsis without decreasing efficacy by shortening the rub-in time of alcohol-based handrubs to 15 seconds.

Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study (2019)
Journal Article
Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (2019). Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), Article 992. https://doi.org/10.1186/s12889-019-7313-0

Background Chlamydia trachomatis (C. trachomatis) is the most common bacterial sexually transmitted infection in the UK. Recent studies suggest that in addition to the genital tract, C. trachomatis is found in the throat and rectum, suggesting the n... Read More about Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study.

Tracking Staphylococcus aureus in the intensive care unit using Whole-Genome Sequencing (2019)
Journal Article
Dancer, S. J., Adams, C. E., Smith, J., Pichon, B., Kearns, A., & Morrison, D. (2019). Tracking Staphylococcus aureus in the intensive care unit using Whole-Genome Sequencing. Journal of Hospital Infection, 103(1), 13-20. https://doi.org/10.1016/j.jhin.2019.04.016

Background: Staphylococcus aureus remains an important bacterial pathogen worldwide. This study utilized known staphylococcal epidemiology to track S. aureus between different ecological reservoirs in one ten-bed intensive care unit (ICU). Methods... Read More about Tracking Staphylococcus aureus in the intensive care unit using Whole-Genome Sequencing.

The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK (2019)
Journal Article
Hooper, K. M., Casanova, V., Kemp, S., Staines, K. A., Satsangi, J., Barlow, P. G., …Stevens, C. (2019). The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK. Inflammatory Bowel Diseases, 25(9), 1481-1496. https://doi.org/10.1093/ibd/izz039

Background Genetic studies have strongly linked autophagy to Crohn's disease (CD) and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this study was to evaluate the effect of current inflammatory bowel disease (IBD)... Read More about The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK.

Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction (2019)
Journal Article
Wattegedera, S. R., Doull, L. E., Goncheva, M. I., Wheelhouse, N., Watson, D. M., Pearce, J., …Entrican, G. (2019). Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction. Frontiers in Immunology, 9, https://doi.org/10.3389/fimmu.2018.03025

Successful mammalian pregnancies are a result of complex physiological, endocrinological and immunological processes that combine to create an environment where the mother is tolerant to the semi-allogeneic fetus. Our knowledge of the mechanisms that... Read More about Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction.

Ferlavirus-related deaths in a collection of viperid snakes (2018)
Journal Article
Flach, E. J., Dagleish, M. P., Feltrer, Y., Gill, I. S., Marschang, R. E., Masters, N., …Wheelhouse, N. M. (2018). Ferlavirus-related deaths in a collection of viperid snakes. Journal of Zoo and Wildlife Medicine, 49(4), 983-995. https://doi.org/10.1638/2017-0223.1

Between June and October 2013 26 snakes of six viperid species kept in two adjoining rooms died (n = 16) or were euthanized on medical (1) or welfare grounds (9). Two were from the main zoo collection, but the other 24 had been imported and quarantin... Read More about Ferlavirus-related deaths in a collection of viperid snakes.

Four Steps to Clean Hospitals: Look; Plan; Clean; and Dry (2018)
Journal Article
Dancer, S. J., & Kramer, A. (2019). Four Steps to Clean Hospitals: Look; Plan; Clean; and Dry. Journal of Hospital Infection, 103(1), e1-e8. https://doi.org/10.1016/j.jhin.2018.12.015

Background Now that cleaning and decontamination are recognised as integral to infection control, it is timely to examine the process in more detail. This is because cleaning practices vary widely within healthcare districts and it is likely that bo... Read More about Four Steps to Clean Hospitals: Look; Plan; Clean; and Dry.