Prof Peter Barlow P.Barlow@napier.ac.uk
Professor
Cathelicidins as novel therapeutic antiviral agents in Rhinovirus infection
People Involved
Dr Craig Stevens C.Stevens@napier.ac.uk
Associate Professor
Project Description
We have identified the human cathelicidn LL-37 as having potent direct antiviral activity against human rhinovirus (HRV), together with the capacity to alter death pathways in HRV-infected cells, as a potential host defence mechanism. We propose to characterise the mechanism by which LL-37 exerts antiviral effects towards HRV, and to access the potential for both exogenous LL-37 and Vitamin D to be used as antiviral therapeutics in this infection.
| Status | Project Complete |
|---|---|
| Funder(s) | Chief Scientists Office |
| Value | £163,152.00 |
| Project Dates | May 1, 2015 - Jun 30, 2017 |
You might also like
An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for the treatment of paediatric IBD Sep 1, 2014 - Aug 31, 2017
Recent genetic discoveries, principally identification of NOD2 and ATG16L1 as susceptibility loci, strongly implicate a dysregulated host response to enteric bacteria and the autophagy pathway in the pathogenesis of Crohn’s disease (CD). Several micr...
Read More about An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for the treatment of paediatric IBD.
Electrolysed Water for Post-Harvest Washing (JadooJal) Mar 1, 2017 - Aug 31, 2019
assist the development of a novel electrolysed water based application to reduce spoilage and microbial contamination of a variety of fresh produce types of importance to Indian commerce.
The Antiviral activities of the cationic host defence peptide LL-37 against Rhinovirus Feb 1, 2013 - Nov 12, 2014
A pump-priming proposal designed to investigate the potential for LL-37, a human cationic host defence peptide, to inhibit Rhinovirus infection and/or target cells infected with Rhinovirus for induction of apoptotic cell death
Development of a novel 3D culture system to understand bone:cartilage crosstalk in osteoarthritis Sep 1, 2018 - Apr 30, 2023
Osteoarthritis affects more than 9 million people in the UK and is the leading cause of disability. In osteoarthritis, joint tissues (cartilage and bone) undergo structural damage which ultimately produces pain and the impairment of normal activities...
Read More about Development of a novel 3D culture system to understand bone:cartilage crosstalk in osteoarthritis.
IBD drug effect on autophagy (IDEA) Oct 1, 2017 - Mar 31, 2018
An investigation of commonly used IBD drugs on autophagy pathway activity and potential therapeutic benefit for treatment of paediatric IBD