Outputs (209)

Antiviral host defence peptides. (2016)
Book Chapter
Sousa, F. H., Casanova, V., Stevens, C., & Barlow, P. G. (2016). Antiviral host defence peptides. In R. M. Epand (Ed.), Host Defense Peptides and Their Potential as Therapeutic Agents (57-94). Springer. https://doi.org/10.1007/978-3-319-32949-9_3

The on going global mortality and morbidity associated with viral pathogens highlights the need for the continued development of effective, novel antiviral molecules. The antiviral activity of cationic host defence peptides is of significant interest... Read More about Antiviral host defence peptides..

Blood lactate thresholds and walking/running economy are determinants of backpack-running performance in trained soldiers (2016)
Journal Article
Simpson, R. J., Graham, S. M., Connaboy, C., Clement, R., Pollonini, L., & Florida-James, G. D. (2017). Blood lactate thresholds and walking/running economy are determinants of backpack-running performance in trained soldiers. Applied Ergonomics, 58, 566-

We developed a standardized laboratory treadmill protocol for assessing physiological responses to a simulated backpack load-carriage task in trained soldiers, and assessed the efficacy of blood lactate thresholds (LTs) and economy in predicting futu... Read More about Blood lactate thresholds and walking/running economy are determinants of backpack-running performance in trained soldiers.

MAPK Activation Is Essential for Waddlia chondrophila Induced CXCL8 Expression in Human Epithelial Cells (2016)
Journal Article
Storrie, S., Longbottom, D., Barlow, P. G., & Wheelhouse, N. (2016). MAPK Activation Is Essential for Waddlia chondrophila Induced CXCL8 Expression in Human Epithelial Cells. PLOS ONE, 11(3), Article e0152193. https://doi.org/10.1371/journal.pone.0152193

Background Waddlia chondrophila (W. chondrophila) is an emerging agent of respiratory and reproductive disease in humans and cattle. The organism is a member of the order Chlamydiales, and shares many similarities at the genome level and in growth s... Read More about MAPK Activation Is Essential for Waddlia chondrophila Induced CXCL8 Expression in Human Epithelial Cells.

Phosphomimetic Mutation of the N-Terminal Lid of MDM2 Enhances the Polyubiquitination of p53 through Stimulation of E2-Ubiquitin Thioester Hydrolysis (2014)
Journal Article
Fraser, J. A., Worrall, E. G., Lin, Y., Landre, V., Pettersson, S., Blackburn, E., Walkinshaw, M., Muller, P., Vojtesek, B., Ball, K., & Hupp, T. R. (2015). Phosphomimetic Mutation of the N-Terminal Lid of MDM2 Enhances the Polyubiquitination of p53 throu

Mouse double minute 2 (MDM2) has a phosphorylation site within a lid motif at Ser17 whose phosphomimetic mutation to Asp17 stimulates MDM2-mediated polyubiquitination of p53. MDM2 lid deletion, but not Asp17 mutation, induced a blue shift in the λm... Read More about Phosphomimetic Mutation of the N-Terminal Lid of MDM2 Enhances the Polyubiquitination of p53 through Stimulation of E2-Ubiquitin Thioester Hydrolysis.

Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development (2014)
Journal Article
Girardi, G., Fraser, J., Lennen, R., Vontell, R., Jansen, M., & Hutchison, G. (2015). Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict

In the current study, we have developed a magnetic resonance imaging-based method for non-invasive detection of complement activation in placenta and foetal brain in vivo in utero. Using this method, we found that anti-complement C3-targeted ultras... Read More about Imaging of activated complement using ultrasmall superparamagnetic iron oxide particles (USPIO) - conjugated vectors: an in vivo in utero non-invasive method to predict placental insufficiency and abnormal fetal brain development.

Antiviral potential of cathelicidins (2013)
Journal Article
Barlow, P. G., Findlay, E. G., Currie, S. M., & Davidson, D. J. (2014). Antiviral potential of cathelicidins. Future Microbiology, 9(1), 55-73. https://doi.org/10.2217/fmb.13.135

The global burden of morbidity and mortality arising from viral infections is high; however, the development of effective therapeutics has been slow. As our understanding of innate immunity has expanded over recent years, knowledge of natural host de... Read More about Antiviral potential of cathelicidins.

Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response (2014)
Journal Article
Wheelhouse, N., Coyle, C., Barlow, P. G., Mitchell, S., Greub, G., Baszler, T., …Longbottom, D. (2014). Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response. PLOS ONE, 9(7), Article e102386.

BACKGROUND Waddlia chondrophila (W. chondrophila) is an emerging abortifacient organism which has been identified in the placentae of humans and cattle. The organism is a member of the order Chlamydiales, and shares many similarities at the genome... Read More about Waddlia chondrophila Infects and Multiplies in Ovine Trophoblast Cells Stimulating an Inflammatory Immune Response.

Pro-inflammatory interactions between particles, metals and lung cells (2004)
Presentation / Conference Contribution
Donaldson, K., Hibbs, L., Heal, M., Tran, C. L., Lightbody, J., Barlow, P. G., …Stone, V. (2004). Pro-inflammatory interactions between particles, metals and lung cells. In Effects of Air Contaminants on the Respiratory Tract - Interpretations from

No abstract available.

Nanoparticle and metal interactions and their impact on lung toxicology (2005)
Presentation / Conference Contribution
Wilson, M. R., Barlow, P. G., Hutchison, G. R., Guy, K., Griffiths, A., Simpson, R. J., …Stone, V. (2005). Nanoparticle and metal interactions and their impact on lung toxicology. In Proceedings of the Ninth Annual UK Review Meeting on Outdoor and Indo

No abstract available.

Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37 (2011)
Journal Article
Barlow, P. G., Svoboda, P., Mackellar, A., Nash, A. A., York, I. A., Pohl, J., …Donis, R. O. (2011). Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37. PLOS ONE, 6(10), Article e25333. htt

The extensive world-wide morbidity and mortality caused by influenza A viruses highlights the need for new insights into the host immune response and novel treatment approaches. Cationic Host Defense Peptides (CHDP, also known as antimicrobial peptid... Read More about Antiviral Activity and Increased Host Defense against Influenza Infection Elicited by the Human Cathelicidin LL-37.

Improved protection against avian influenza H5N1 virus by a single vaccination with virus-like particles in skin using microneedles (2010)
Journal Article
Song, J., Kim, Y., Barlow, P. G., Hossain, M. J., Park, K., Donis, R. O., …Kang, S. (2010). Improved protection against avian influenza H5N1 virus by a single vaccination with virus-like particles in skin using microneedles. Antiviral Research, 88(2), 2

To develop a more effective vaccination method against H5N1 virus, we investigated the immunogenicity and protective efficacy after skin vaccination using microneedles coated with influenza virus-like particles containing hemagglutinin derived from A... Read More about Improved protection against avian influenza H5N1 virus by a single vaccination with virus-like particles in skin using microneedles.

NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy (2010)
Journal Article
Fox, S., Wilkinson, T. S., Wheatley, P. S., Xiao, B., Morris, R. E., Sutherland, A., …Rossi, A. G. (2010). NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy. Acta biomaterialia, 6(4), (1515-1521). doi:10.1016/j

Nitric oxide (NO) is important for the regulation of a number of diverse biological processes, including vascular tone, neurotransmission, inflammatory cell responsiveness, defence against invading pathogens and wound healing. Transition metal exchan... Read More about NO-loaded Zn2+-exchanged zeolite materials: A potential bifunctional anti-bacterial strategy.

The Human Cathelicidin LL-37 Preferentially Promotes Apoptosis of Infected Airway Epithelium (2010)
Journal Article
Barlow, P. G., Beaumont, P. E., Cosseau, C., Mackellar, A., Wilkinson, T. S., Hancock, R. E. W., …Davidson, D. J. (2010). The Human Cathelicidin LL-37 Preferentially Promotes Apoptosis of Infected Airway Epithelium. American Journal of Respiratory Cell

Cationic host defense peptides are key, evolutionarily conserved components of the innate immune system. The human cathelicidin LL-37 is an important cationic host defense peptide up-regulated in infection and inflammation, specifically in the human... Read More about The Human Cathelicidin LL-37 Preferentially Promotes Apoptosis of Infected Airway Epithelium.

A Candidate H1N1 Pandemic Influenza Vaccine Elicits Protective Immunity in Mice (2010)
Journal Article
Steitz, J., Barlow, P. G., Hossain, J., Kim, E., Okada, K., Kenniston, T., …Gambotto, A. (2010). A Candidate H1N1 Pandemic Influenza Vaccine Elicits Protective Immunity in Mice. PLOS ONE, 5(5), Article e10492. https://doi.org/10.1371/journal.pone.001049

Background In 2009 a new pandemic disease appeared and spread globally. The recent emergence of the pandemic influenza virus H1N1 first isolated in Mexico and USA raised concerns about vaccine availability. We here report our development of an adeno... Read More about A Candidate H1N1 Pandemic Influenza Vaccine Elicits Protective Immunity in Mice.

Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages (2009)
Journal Article
Li, H., Barlow, P. G., Bylund, J., Mackellar, A., Björstad, Å., Conlon, J., …Davidson, D. J. (2009). Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages. Journal of Le

Cathelicidins are CHDP with essential roles in innate host defense but also more recently associated with the pathogenesis of certain chronic diseases. These peptides have microbicidal potential and the capacity to modulate innate immunity and inflam... Read More about Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages.

Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure (2007)
Journal Article
Barlow, P. G., Brown, D. M., Donaldson, K., MacCallum, J., & Stone, V. (2008). Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure. Cell Biology and Toxicology, 24(3), 243-252. https://doi.org/10.1007/s10565-007-9033-y

Increased levels of particulate air pollution (PM10) have been implicated as a causal agent in pulmonary disease exacerbation and increased deaths from respiratory and cardiovascular disorders. The exact mechanism by which PM10 drives toxicity in the... Read More about Reduced alveolar macrophage migration induced by acute ambient particle (PM10) exposure.

Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation (2007)
Journal Article
Wilson, M. R., Foucaud, L., Barlow, P. G., Hutchison, G. R., Sales, J., Simpson, R. J., & Stone, V. (2007). Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation. Toxicology and Applied Pharmacology, 225(1), 80-89. htt

Particulate air pollution (PM10) consists of a mixture of components, including nanoparticles and metals. Studies from our laboratory have demonstrated that transition metals can potentiate the ability of nanoparticles to induce lung inflammation and... Read More about Nanoparticle interactions with zinc and iron: Implications for toxicology and inflammation.

The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system (2006)
Journal Article
Barlow, P. G., Li, Y., Wilkinson, T. S., Bowdish, D. M. E., Lau, Y. E., Cosseau, C., …Davidson, D. J. (2006). The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immun

The human cathelicidin LL-37 is a cationic host defense peptide (antimicrobial peptide) expressed primarily by neutrophils and epithelial cells. This peptide, up-regulated under conditions of inflammation, has immunomodulatory and antimicrobial funct... Read More about The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system.

Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages. (2005)
Journal Article
Barlow, P. G., Clouter-Baker, A., Donaldson, K., MacCallum, J., & Stone, V. (2005). Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages. Particle and fibre toxicology, 2(1), 11-24. https://doi.org/10.

Background - Alveolar macrophages are a key cell in dealing with particles deposited in the lungs and in determining the subsequent response to that particle exposure. Nanoparticles are considered a potential threat to the lungs and the mechanism of... Read More about Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages..

Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration (2004)
Journal Article
Barlow, P., Donaldson, K., MacCallum, J., Clouter, A., & Stone, V. (2005). Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration. Toxicology Letters, 155(3), 397-401. https://doi.org/10.1016/j.toxlet.2004.1

Objective: To assess whether fine and ultrafine particles (nanoparticles) have the capacity to activate factors in serum that would induce macrophage migration. This is a model previously reported to investigate complement activation by other respir... Read More about Serum exposed to nanoparticle carbon black displays increased potential to induce macrophage migration.